N-BUTYLIDENEPHTHALIDE
- CAS No.
- 551-08-6
- Chemical Name:
- N-BUTYLIDENEPHTHALIDE
- Synonyms
- 3-BUTYLIDENEPHTHALIDE;Bdph;BUTYLIDENE PHTHALIDE;3-butylidene-phthalid;3-Butylideneisobenzofuran-1(3H)-one;FEMA 3333;Ai3-37306;NSC 325307;Einecs 208-991-3;Butenylphthalide
- CBNumber:
- CB0173298
- Molecular Formula:
- C12H12O2
- Molecular Weight:
- 188.22
- MDL Number:
- MFCD00047319
- MOL File:
- 551-08-6.mol
- MSDS File:
- SDS
| Melting point | 82.5°C |
|---|---|
| Boiling point | 139-142 °C/5 mmHg (lit.) |
| Density | 1.103 g/mL at 25 °C (lit.) |
| FEMA | 3333 | 3-BUTYLIDENEPHTHALIDE |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Oil |
| color | Colourless to Yellow |
| Odor | at 10.00 % in dipropylene glycol. herbal lovage celery |
| Odor Type | herbal |
| JECFA Number | 1170 |
| BRN | 5145 |
| InChIKey | WMBOCUXXNSOQHM-FLIBITNWSA-N |
| LogP | 3.72 |
| Substances Added to Food (formerly EAFUS) | 3-BUTYLIDENEPHTHALIDE |
| CAS DataBase Reference | 551-08-6(CAS DataBase Reference) |
| FDA UNII | S9178G4B3F |
| EPA Substance Registry System | 1(3H)-Isobenzofuranone, 3-butylidene- (551-08-6) |
N-BUTYLIDENEPHTHALIDE price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | A10353 | n-Butylidenephthalide, (E)+(Z), 95% | 551-08-6 | 10g | $31.65 | 2024-03-01 | Buy |
| Alfa Aesar | A10353 | n-Butylidenephthalide, (E)+(Z), 95% | 551-08-6 | 50g | $90.65 | 2024-03-01 | Buy |
| Alfa Aesar | A10353 | n-Butylidenephthalide, (E)+(Z), 95% | 551-08-6 | 250g | $342 | 2023-06-20 | Buy |
| Usbiological | 299818 | 3-Butylidenephthalide | 551-08-6 | 20mg | $297 | 2021-12-16 | Buy |
| TRC | B692250 | 3-ButylidenePhthalide(CisTransmixture) | 551-08-6 | 25g | $425 | 2021-12-16 | Buy |
N-BUTYLIDENEPHTHALIDE Chemical Properties,Uses,Production
Description
N-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder. It is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort. It has found that it can regulate tumor stem cell genes EZH2/AXL and reduced its migration and invasion in glioblastoma. Moreover, it can induce apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2a and telomerase activity. Therefore, it is a potential cancer chemotherapy drug. Moreover, It can also exhibit protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3. Finally, it has certain antiplatelet effect.
Reference
- Lin, Po Cheng, et al. "Orphan nuclear receptor, Nurr‐77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor." Journal of Neurochemistry 106.3(2010):1017-1026.
- Rajamani, K, et al. "n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3." Neuropharmacology 117(2017):434-446.
- Teng, C. M., et al. "Antiplatelet effect of butylidenephthalide." BBA General Subjects 924.3(1987):375-382.
Chemical Properties
3-Butylidenephthalide has a pervasive warm spicy aroma.
Occurrence
Reported as occurring naturally in the fruits and roots of Ligusticum acutilobum and lovage (Levisticum officinale) seeds, roots and leaves.
Uses
3-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder.
Definition
ChEBI: A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity.
Taste threshold values
Taste characteristics at 15 ppm: celery, green, vegetable-like with a herbal nuance.
General Description
3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort.
Safety Profile
Moderately toxic by ingestion. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
target
Nrf2 | TNF-α | NO | IL Receptor
N-BUTYLIDENEPHTHALIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 1696 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
View Lastest Price from N-BUTYLIDENEPHTHALIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | 3-Butylidenephthalide
551-08-6
|
US $1.00 / KG | 1KG | 99.91% | 200000 | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-08-10 | N-BUTYLIDENEPHTHALIDE
551-08-6
|
US $27.00 / KG | 1KG | 99% | 20tons | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-06-30 | N-BUTYLIDENEPHTHALIDE
551-08-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 3-Butylidenephthalide
551-08-6
- US $1.00 / KG
- 99.91%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- N-BUTYLIDENEPHTHALIDE
551-08-6
- US $27.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- N-BUTYLIDENEPHTHALIDE
551-08-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd