ChemicalBook >> CAS DataBase List >>N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE structure

CAS No.: 136132-67-7

Chemical Name:: N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

Synonyms: CPSB;CTSB;z-rr-amc;APP secretase;Z-RR-AMC, 2HCL;Z-ARG-ARG-MCA.HCL;Z-ARG-ARG-AMC 2HCL;Z-Arg-Arg-AMC/Z-RR-AMC;Cathepsin B Active human;Z-ARG-ARG-MCA HYDROCHLORIDE

CBNumber:: CB0188887

Molecular Formula:: C30H40ClN9O6

Molecular Weight:: 658.15

MDL Number:: MFCD00133576

MOL File:: 136132-67-7.mol

Last updated:2023-04-23 13:52:06

Request For Quotation

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Properties

storage temp.	-20°C
form	aqueous solution

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H315-H319-H360D
Precautionary statements	P201-P302+P352-P305+P351+P338-P308+P313
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C5429	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	136132-67-7	5mg	$89.3	2024-03-01	Buy
Sigma-Aldrich	C5429	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	136132-67-7	25mg	$306	2024-03-01	Buy
Sigma-Aldrich	219392	Cathepsin B Substrate III, Fluorogenic Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.		25MG	$171	2024-03-01	Buy
Sigma-Aldrich	SRP0289	Cathepsin B Active human recombinant, expressed in FreeStyle? 293-F cells, ≥90% (SDS-PAGE)	136132-67-7	10μG	$626	2023-06-20	Buy
American Custom Chemicals Corporation	PEP0004304	Z-ARG-ARG-7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE 95.00%	136132-67-7	5MG	$634.11	2021-12-16	Buy

Product number	Packaging	Price	Buy
C5429	5mg	$89.3	Buy
C5429	25mg	$306	Buy
219392	25MG	$171	Buy
SRP0289	10μG	$626	Buy
PEP0004304	5MG	$634.11	Buy

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

as a cathepsin B substrate in zymography analysis of protease in feces extract.
in cathepsin B activity assay.
as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

General Description

Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1.

Biochem/physiol Actions

Cathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions.

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Suppliers

Global( 62)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9358	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	3000	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9823	79
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	15878	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919	eric@peptidego.com	China	6119	58

Supplier	Advantage
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
Zhengzhou Anbu Chem Co.,Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
DONBOO AMINO ACID COMPANY	58
Sinopharm Chemical Reagent Co,Ltd.	79
Shanghai Macklin Biochemical Co.,Ltd.	55
Sigma-Aldrich	80
Hangzhou Peptidego Biotech Co.,Ltd.	58

View Lastest Price from N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-04-17	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride 136132-67-7	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2020-01-09	N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE 136132-67-7	US $1.00 / g	1g	≥98%	g/kg/Ton	Career Henan Chemical Co

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride
136132-67-7
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
136132-67-7
US $1.00 / g
≥98%
Career Henan Chemical Co

136132-67-7(N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE)Related Search:

Z-Arg-AMC CATHEPSIN B SUBSTRATE I, COLORIMETRIC N-ALPHA-CBZ-ARG-ARG-PRO-PHE-HIS-STA-ILE-HIS-N-EPSILON-BOC-LYS METHYL ESTER NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE Z-ARG-AMC HCL

Perindopril L-Arginine N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Z-ARG-ARG-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN BENZYL N-(2-AMINOETHYL)CARBAMATE HYDROCHLORIDE L(+)-Arginine

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-ORN-AMC 2 HCL L-ARGININE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-GLY-GLY-AMC HCL H-ARG-ALA-NH2 2 HCL

L-ARGININE 7-AMIDO-4-METHYLCOUMARIN DIHYDROCHLORIDE 2-(METHYLAMINO)-N-(4-METHYLPHENYL)ACETAMIDE HYDROCHLORIDE H-ALA-ARG-AMC HCL

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N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Z-ARG-ARG-7-AMIDO-4-METHYL COUMARIN, DIHCL Z-ARG-ARG-AMC 2HCL Z-ARG-ARG-AMC HYDROCHLORIDE SALT Z-ARG-ARG-MCA HYDROCHLORIDE Z-ARG-ARG-MCA(HYDROCHLORIDE FORM) Z-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN 2HCL Z-RR-AMC, 2HCL z-arg-arg-7-amido-4-methylcoumarin hydrochloride z-rr-amc Z-ARG-ARG-MCA.HCL ANTI-CATB (CENTER) antibody produced in rabbit APP secretase CPSB CTSB Cathepsin B Active human BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE CATHEPSIN B SUBSTRATE III, FLUOROGENIC CATHEPSIN B SUBSTRATE IV, FLUOROGENIC na-cbz-arg-arg 7-amido-4-methylcoumarin hydrochlo NA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORI N-CBZ-ILE-GLU-THR-ASP-7-AMINO-4- TRIFLUO ROMETHYLCOU Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,Z-RR-AMC Z-Arg-Arg-AMC/Z-RR-AMC N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE USP/EP/BP Recombinant Mouse Cathepsin B/Ctsb Protein, His Tag Recombinant Human Cathepsin B/CTSB Protein, His Tag Z-Arg-Arg-7-amido-4-methylcoumarin CBZ-Arg-Arg-7-amido-4-methylcoumarin hydrochloride Mouse Anti-Caspase 8 antibody Z-Arg-Arg-AMC hydrochloride 136132-67-7 C30H39N9O6 C30H41Cl2N9O6 C30H39N9O6HCl Cathepsins and Granzymes Cathepsin B Caspases Caspase 8 Cell Signaling and Neuroscience Cell Biology Apoptosis and Cell Cycle BioChemical Substrates Substrates