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Methyl 3-amino-4-methylthiophene-2-carboxylate

Methyl 3-amino-4-methylthiophene-2-carboxylate Structure
Methyl 3-amino-4-methylthiophene-2-carboxylate structure
CAS No.
85006-31-1
Chemical Name:
Methyl 3-amino-4-methylthiophene-2-carboxylate
Synonyms
3-AMINO-4-METHYL-2-THIOPHENECARBOXYLIC ACID METHYL ESTER;3-Amino Articaine;3-AMINO-4-METHYLTHIOPHENECARBOXYLIC ACID METHYL ESTER;M3A4MT2C;Articaine-002;Articaine Impurity I;Articaine Impurity 9;LABOTEST-BB LT00453517;Articaine EP Impurity I;Articaine intermediate E
CBNumber:
CB0189112
Molecular Formula:
C7H9NO2S
Molecular Weight:
171.22
MDL Number:
MFCD00051822
MOL File:
85006-31-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:11
Product description Number Pack Size Price
Methyl 3-amino-4-methylthiophene-2-carboxylate 97% 546658 5g $30.3
Methyl 3-amino-4-methylthiophene-2-carboxylate certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland PHR9159 100 mg $891
Methyl 3-amino-4-methylthiophene-2-carboxylate 97% 546658 25g $116
Methyl 3-Amino-4-methylthiophene-2-carboxylate >98.0%(GC) M1772 5g $29
Methyl 3-Amino-4-methylthiophene-2-carboxylate >98.0%(GC) M1772 25g $100
More product size
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Methyl 3-amino-4-methylthiophene-2-carboxylate Properties

Melting point 85-88 °C (lit.)
Boiling point 318.6±37.0 °C(Predicted)
Density 1.264±0.06 g/cm3(Predicted)
Flash point >100°C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 1.71±0.10(Predicted)
form Solid
color Pale Yellow
Water Solubility 1g/L at 35℃
BRN 973196
InChI 1S/C7H9NO2S/c1-4-3-11-6(5(4)8)7(9)10-2/h3H,8H2,1-2H3
InChIKey YICRPERKKBDRSP-UHFFFAOYSA-N
SMILES COC(=O)c1scc(C)c1N
LogP 1.28
CAS DataBase Reference 85006-31-1(CAS DataBase Reference)
FDA UNII 3LA24473AS
NIST Chemistry Reference Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25-22
WGK Germany  2
Hazard Note  Irritant
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

Methyl 3-amino-4-methylthiophene-2-carboxylate price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 546658 Methyl 3-amino-4-methylthiophene-2-carboxylate 97% 85006-31-1 5g $30.3 2026-03-19 Buy
Sigma-Aldrich PHR9159 Methyl 3-amino-4-methylthiophene-2-carboxylate certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland 85006-31-1 100 mg $891 2026-03-19 Buy
Sigma-Aldrich 546658 Methyl 3-amino-4-methylthiophene-2-carboxylate 97% 85006-31-1 25g $116 2026-03-19 Buy
TCI Chemical M1772 Methyl 3-Amino-4-methylthiophene-2-carboxylate >98.0%(GC) 85006-31-1 5g $29 2026-03-19 Buy
TCI Chemical M1772 Methyl 3-Amino-4-methylthiophene-2-carboxylate >98.0%(GC) 85006-31-1 25g $100 2026-03-19 Buy
Product number Packaging Price Buy
546658 5g $30.3 Buy
PHR9159 100 mg $891 Buy
546658 25g $116 Buy
M1772 5g $29 Buy
M1772 25g $100 Buy

Methyl 3-amino-4-methylthiophene-2-carboxylate Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B.

Application

methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.
7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.
The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield.

Definition

ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid.

Methyl 3-amino-4-methylthiophene-2-carboxylate synthesis

2689-70-5
85006-31-1
Synthesis of Methyl 3-amino-4-methylthiophene-2-carboxylate from Methyl 2-Methyl-3-Oxo-Tetrahydrothiophene-2-Carbonate

Methyl 3-amino-4-methylthiophene-2-carboxylate Preparation Products And Raw materials

Raw materials

Methyl thioglycolate Sodium hydride Ethanol Hydroxylamine hydrochloride Methyl methacrylate
Methyl 2-Methyl-3-Oxo-Tetrahydrothiophene-2-Carbonate 4-METHYL-3-AMINO-2-(METHOXYCARBONYL)-4,5-DIHYDROTHIOPHENE

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Preparation Products

Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro- METHYL 3-CHLORO-4-METHYLTHIOPHENE-2-CARBOXYLATE Methyl 3-dimethylamino-4-methylthiophene-2-carboxylate, 97% Thieno[3,2-d]pyriMidine, 2-chloro-7-Methyl-4-(4-Morpholinyl)- 7-(BROMOMETHYL)-2-CHLOROTHIENO[3,2-D]PYRIMIDINE
7-Methylthieno[3,2-d]pyrimidine-2,4-diol tert-butyl 4-methylthiophen-3-ylcarbamate 5-Chlorothieno[3,2-b]pyridine-3-carboxylic acid

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Methyl 3-amino-4-methylthiophene-2-carboxylate Suppliers

Global( 417)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Hebei Xinsheng New Material Technology Co., LTD. 		+86-16632316109 xinshengkeji@xsmaterial.com China 1085 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21591 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29820 58
Jinan Jianfeng Chemical Co., Ltd 		+86-0531-88110457 +8615562555968 info@pharmachemm.com China 311 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Hebei Xinsheng New Material Technology Co., LTD. 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Jinan Jianfeng Chemical Co., Ltd 		58
Standardpharm Co. Ltd. 		58

View Lastest Price from Methyl 3-amino-4-methylthiophene-2-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl 3-amino-4-methylthiophene-2-carboxylate pictures 2026-04-29 Methyl 3-amino-4-methylthiophene-2-carboxylate
85006-31-1
 US $0.00 / Kg/Drum 1KG 99%min HPLC 1000kgs WUHAN FORTUNA CHEMICAL CO., LTD
Methyl 3-amino-4-methylthiophene-2-carboxylate pictures 2026-03-20 Methyl 3-amino-4-methylthiophene-2-carboxylate
85006-31-1
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
Methyl 3-amino-4-methylthiophene-2-carboxylate pictures 2026-02-02 Methyl 3-amino-4-methylthiophene-2-carboxylate
85006-31-1
 US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

Methyl 3-amino-4-methylthiophene-2-carboxylate Spectrum

Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)1HNMRMethyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)IR

85006-31-1(Methyl 3-amino-4-methylthiophene-2-carboxylate)Related Search:

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2-Methylthiophene Methyl acrylate RESMETHRIN Tribenuron methyl Methyl carbamate
Glycine Methyl METHYL 3-AMINO-4-CYANOTHIOPHENE-2-CARBOXYLATE

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M3A4MT2C METHYL 3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLATE Methyl 3-amino-4-methyl-2-thenoate METHYL 3-AMINO-4-METHYL-2-THIOPHENECARBOXYLATE LABOTEST-BB LT00453517 3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER Methyl 3-Amino-4-Methylthiophen-2-Carboxylate METHYL 3-AMINO-4-METHYLTHIOPHENE-2-CARBO 3-Amino-4-Methyl-2-ThiophenecarboxylicMethylester Articaine intermediate E 3-Amino-2-methoxycarbonyl-4-methylthiophene 3-Amino-2-carbomethoxy-4-methylthiophen 3-Amino-4-methylthiophene-2-carboxylic 2-Thiophenecarboxylic acid, 3-amino-4-methyl-, methyl ester 4-Methyl-3-aminothiophene-2-carboxylic acid methyl ester Methyl 3-amino-4-methylthiophene-2-carboxylate ,99% 3-AMino-4-Methyl-2-thiophene carboxylic acid ester 3-Amino-2-(methoxycarbonyl)-4-methylthiophene, Methyl 3-amino-4-methyl-2-thenoate Articaine IMpurity I (Methyl 3-AMino-4-Methylthiophene-2-Carboxylate) Methyl 3-AMino-4-Methylthiophene-2-carboxylate , 98.0%(GC) Methyl3-amino-4-methylthiophene-2-carboxylate,98% Methyl 3-amino-4-methylthiophene-2-carboxylate(Articaine Intermediates) 3-AMINO 4-METHYL-2-THIOPHENE CARBOXYLICACID METHYL ESTER IMPORTED VIDE B/E 3189721/ 06.11.2015][CLEAR AGAINST ADVANCE L Articaine Impurity 9(Articaine EP Impurity I） Articaine EP Impurity I Methyl3-Amino-4-methylthiophene-2-carboxylate> Articaine-002 Articaine Impurity I 3- amino-4-methyl thiophene - 2-carboxylate, methyl ester Methyl 3-amino-4-methylthiophene-2-carboxylate ISO 9001：2015 REACH Articaine Impurities1819 Articaine Impurity 9 3-AMINO-4-METHYL-2-THIOPHENECARBOXYLIC ACID METHYL ESTER 3-AMINO-4-METHYLTHIOPHENECARBOXYLIC ACID METHYL ESTER 3-Amino Articaine Articaine Hydrochloride EP Impurity I Methyl 3-Amino-4-methylthiophene-2-carboxylate (3-Aminoarticaine) Methyl 3-amino-4-methylthiophene-2-carboxylate (Articaine Impurity) Articaine Hydrochloride Impurity I 85006-31-1 C7H9SNO2 Heterocyclic Building Blocks Thiophenes Building Blocks Thiophenes & Benzothiophenes Building Blocks C7 to C9 Chemical Synthesis Heterocyclic Building Blocks Thiophenes Thiophen Esters Thiophenes & Benzothiophenes Thiophene&Benzothiophene Organic acids API intermediates 1 ADVANCED INT.