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(R)-(+)-HA-966

(R)-(+)-HA-966 structure

CAS No.: 123931-04-4

Chemical Name:: (R)-(+)-HA-966

Synonyms: RMA-5;(+)-HA-966;HA966-001-R;Zinc03791818;(R)-(+)-HA-966;(R)(+)HA966,(R) (+) HA 966;R(+)-HA-966 R(+)-3-AMINO-1-HYDROX;(3R)-3-Amino-1-hydroxy-2-pyrrolidinone;R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE;(R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE

CBNumber:: CB0190556

Molecular Formula:: C4H8N2O2

Molecular Weight:: 116.12

MDL Number:: MFCD00078583

MOL File:: 123931-04-4.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

Product description	Number	Pack Size	Price
R(+)-HA-966 solid	H130	5mg	$155.8
(R)-(+)-HA-966 ≥98%(HPLC)	0281	10	$161
(R)-(+)-HA-966	H105803	50mg	$730
(R)-(+)-HA-966	B6243	10mg	$234
(R)-(+)-HA-966 95.00%	API0007692	10MG	$673.08

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(R)-(+)-HA-966 Properties

Melting point	166℃
Boiling point	258.6±50.0 °C(Predicted)
Density	1.436±0.06 g/cm3(Predicted)
storage temp.	Desiccate at RT
solubility	H₂O: soluble
pka	7.19±0.20(Predicted)
form	solid
color	white
optical activity	[α]22/D +103°, c = 1 in H2O(lit.)
Water Solubility	Soluble to 100 mM in water
FDA UNII	2N9Q4C7WMT
UNSPSC Code	12352111
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	3

(R)-(+)-HA-966 price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H130	R(+)-HA-966 solid	123931-04-4	5mg	$155.8	2025-07-31	Buy
Tocris	0281	(R)-(+)-HA-966 ≥98%(HPLC)	123931-04-4	10	$161	2021-12-16	Buy
TRC	H105803	(R)-(+)-HA-966	123931-04-4	50mg	$730	2021-12-16	Buy
ApexBio Technology	B6243	(R)-(+)-HA-966	123931-04-4	10mg	$234	2021-12-16	Buy
American Custom Chemicals Corporation	API0007692	(R)-(+)-HA-966 95.00%	123931-04-4	10MG	$673.08	2021-12-16	Buy

Product number	Packaging	Price	Buy
H130	5mg	$155.8	Buy
0281	10	$161	Buy
H105803	50mg	$730	Buy
B6243	10mg	$234	Buy
API0007692	10MG	$673.08	Buy

(R)-(+)-HA-966 Chemical Properties,Uses,Production

Uses

(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor.

Biological Activity

Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.)^[3].
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g)^[1].

Animal Model:	Sprague-Dawley rats (11 to 12 weeks old)^[3]
Dosage:	10 mg/kg
Administration:	IV
Result:	Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA.

IC 50

NMDA Receptor

storage

Desiccate at RT

(R)-(+)-HA-966 Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(+)-HA-966 Suppliers

Global( 51)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	+8618950047208	ellena@amitychem.com	China	43416	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15838	69
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7892	64
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5691	66
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Zhengzhou AiXi Technology Co., Ltd.	0371-56787280 13137706083	m18539565376@163.com	China	970	55
XinYao(Shenzhen) Biological Technology Co., Ltd.	0755-89880280	3004662104@qq.com	China	1829	58

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Tetranov Biopharm	64
China DongFan Chemical Co.,LTD	66
EMMX Biotechnology LLC	60
Zhengzhou AiXi Technology Co., Ltd.	55
XinYao(Shenzhen) Biological Technology Co., Ltd.	58

123931-04-4((R)-(+)-HA-966)Related Search:

1H-Pyrrol-3-amine(9CI) AMINO ACID HYDROXAMATES GLYCINE HYDROXAMATE (S)-(-)-HA-966 (+/-)-HA-966 3-AMINO-PYRROLIDIN-2-ONE

(+/-)-HA-966 (R)-3-Aminopyrrolidine (R)-(+)-HA-966

1of2

R(+)-HA-966 R(+)-3-AMINO-1-HYDROX (R)-(+)-HA-966 R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE (R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Zinc03791818 (3R)-3-Amino-1-hydroxy-2-pyrrolidinone (R)-3-amino-1-hydroxypyrrolidin-2-one 2,2,2-trifluoroacetate 2-Pyrrolidinone, 3-amino-1-hydroxy-, (3R)- (+)-HA-966 HA966-001-R (R)(+)HA966,(R) (+) HA 966 RMA-5 123931-04-4 Ion Channels Ionotropic Glutamate Receptor Modulators Ligand-Gated Ion Channels Cell Biology Cell Signaling and Neuroscience BioChemical Glutamate receptor