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Description Uses Safety References
Methylisothiazolinone structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Methylisothiazolinone Properties

Melting point:
254-256 °C(lit.)
Boiling point:
bp0.03 93°
1.25 (14% aq.)
vapor pressure 
<0.1 mm Hg ( 25 °C)
CAS DataBase Reference
2682-20-4(CAS DataBase Reference)
NIST Chemistry Reference
3(2H)-isothiazolone, 2-methyl-(2682-20-4)
EPA Substance Registry System
3(2H)-Isothiazolone, 2-methyl-(2682-20-4)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H302-H314-H317-H331-H335-H400
Precautionary statements  P261-P273-P280-P305+P351+P338-P310
Hazard Codes  N,C,T
Risk Statements  50/53-50-43-34-20/21/22-37-23-22
Safety Statements  60-61-36/37/39-26-24-45
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  FE1250000
HazardClass  8
PackingGroup  III
HS Code  29349990

Methylisothiazolinone price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 725765 2-Methyl-4-isothiazolin-3-one 95% 2682-20-4 5g $74.1 2018-11-13 Buy
Sigma-Aldrich 725765 2-Methyl-4-isothiazolin-3-one 95% 2682-20-4 25g $293 2018-11-13 Buy
Cayman Chemical 22589 Methylisothiazolinone ≥98% 2682-20-4 1g $20 2018-11-19 Buy
Cayman Chemical 22589 Methylisothiazolinone ≥98% 2682-20-4 5g $65 2018-11-19 Buy
Sigma-Aldrich 73569 2-Methyl-4-isothiazolin-3-one analytical standard 2682-20-4 1g $92.1 2018-11-13 Buy

Methylisothiazolinone Chemical Properties,Uses,Production


Methylisothiazolinone (also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of  isothiazolinones.
Methylisothiazolinone is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative. It is also used to control the growth of mold, mildew, and sapstain on wood products. It is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents. Nevertheless, methylisothiazolinone is allergenic. It is reported that methylisothiazolinone in rinse-off products causes allergic contact dermatitis.


Methylisothiazolinone, or MIT as it is sometimes known, is a preservative used in cosmetics and beauty products. It is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.”Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal. Ultimately, Methylisothiazolinone is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo. It is only approved for use in rinse-off formulas and at low concentrations.


Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MIT would not be neurotoxic as used in cosmetics. Although recognizing that MIT was a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.0 1%) or less would not be expected to pose a sensitization risk. Accordingly, MIT may be safely used as a preservative in cosmetics up to that concentration.


[2] K. Yazar, M. D. Lundov, A. Faurschou, M. Matura, A. Boman, J. D. Johansen, C. Lidén (2015) Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study, 173, 115-122

Chemical Properties

Yellow Low melting Solid


2-Methyl-4-isothiazolin-3-one is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c ontaining solution.


A potent biocide useful for controlling microbial growth


methylisothiazolinone is a preservative.


ChEBI: A 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM.

Contact allergens

MI is generally associated with MCI, in Kathon? CG, MCI/MI, and Euxyl? K 100. This preservative is currently used in water-based products such as cosmetics, paints, and glues. Skin contact with concentrated solution can cause severe irritant dermatitis.

Methylisothiazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

Methylisothiazolinone Suppliers

Global( 232)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21701 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 CHINA 2861 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880086 CHINA 575 58
career henan chemical co
+86-371-86658258 CHINA 29979 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23978 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28236 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 8922 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651 CHINA 2313 58

View Lastest Price from Methylisothiazolinone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-21 2-Methyl-4-Isothiazolin-3-one
US $7.00 / KG 1KG 99% 1000KG career henan chemical co

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