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Methylisothiazolinone

Description Uses Safety References
Methylisothiazolinone
Methylisothiazolinone structure
CAS No.
2682-20-4
Chemical Name:
Methylisothiazolinone
Synonyms
MIT50%;MIT-20;KATHONCG;Skycide 100;MIT, 100ppm;Isothiazolone;2-Methyl-4-iso;Isothiazolone 14%;METHYLISOTHIAZOLIN;METHYLISOTHIAZOLINE
CBNumber:
CB0193926
Molecular Formula:
C4H5NOS
Formula Weight:
115.15
MOL File:
2682-20-4.mol

Methylisothiazolinone Properties

Melting point:
254-256 °C(lit.)
Boiling point:
bp0.03 93°
Density 
1.25 (14% aq.)
vapor pressure 
<0.1 mm Hg ( 25 °C)
storage temp. 
2-8°C
pka
-2.03±0.20(Predicted)
form 
neat
BRN 
606203
InChIKey
BEGLCMHJXHIJLR-UHFFFAOYSA-N
CAS DataBase Reference
2682-20-4(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
2-METHYL-4-ISOTHIAZOLIN-3-ONE
EWG's Food Scores
4-7
FDA UNII
229D0E1QFA
NIST Chemistry Reference
3(2H)-isothiazolone, 2-methyl-(2682-20-4)
EPA Substance Registry System
2-Methyl-3(2H)-isothiazolone (2682-20-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H302-H314-H317-H331-H335-H400
Precautionary statements  P261-P273-P280-P305+P351+P338-P310
Hazard Codes  N,C,T
Risk Statements  50/53-50-43-34-20/21/22-37-23-22
Safety Statements  60-61-36/37/39-26-24-45
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  FE1250000
HazardClass  8
PackingGroup  III
HS Code  29349990

Methylisothiazolinone price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 725765 2-Methyl-4-isothiazolin-3-one 95% 2682-20-4 5g $81.7 2021-03-22 Buy
Sigma-Aldrich 725765 2-Methyl-4-isothiazolin-3-one 95% 2682-20-4 25g $323 2021-03-22 Buy
Sigma-Aldrich 73569 2-Methyl-4-isothiazolin-3-one analytical standard 2682-20-4 1g $101 2021-03-22 Buy
Cayman Chemical 28136 Methylisothiazolinone 2682-20-4 10mL $125 2021-03-22 Buy
Cayman Chemical 28136 Methylisothiazolinone 2682-20-4 25mL $219 2021-03-22 Buy

Methylisothiazolinone Chemical Properties,Uses,Production

Description

Methylisothiazolinone (also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of  isothiazolinones.
Methylisothiazolinone is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative. It is also used to control the growth of mold, mildew, and sapstain on wood products. It is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents. Nevertheless, methylisothiazolinone is allergenic. It is reported that methylisothiazolinone in rinse-off products causes allergic contact dermatitis.

Uses

Methylisothiazolinone, or MIT as it is sometimes known, is a preservative used in cosmetics and beauty products. It is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.”Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal. Ultimately, Methylisothiazolinone is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo. It is only approved for use in rinse-off formulas and at low concentrations.

Safety

Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MIT would not be neurotoxic as used in cosmetics. Although recognizing that MIT was a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.0 1%) or less would not be expected to pose a sensitization risk. Accordingly, MIT may be safely used as a preservative in cosmetics up to that concentration.

References

[1] http://www.safecosmetics.org/get-the-facts/chemicals-of-concern/methylisothiazolinone/
[2] K. Yazar, M. D. Lundov, A. Faurschou, M. Matura, A. Boman, J. D. Johansen, C. Lidén (2015) Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study, 173, 115-122
[3] https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_G-58_1-Oct-98.pdf

Description

MI is contained in Kathon CG, MCI/MI and Euxyl K100. It can cause severe irritant dermatitis, as with Euxyl K100 incorporated in a cleansing cream used by an engine man.

Chemical Properties

Yellow Low melting Solid

Uses

2-Methyl-4-isothiazolin-3-one is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c ontaining solution.

Uses

A potent biocide useful for controlling microbial growth

Uses

methylisothiazolinone is a preservative.

Definition

ChEBI: A 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM.

Contact allergens

MI is generally associated with MCI, in Kathon? CG, MCI/MI, and Euxyl? K 100. This preservative is currently used in water-based products such as cosmetics, paints, and glues. Skin contact with concentrated solution can cause severe irritant dermatitis.

Methylisothiazolinone Preparation Products And Raw materials

Raw materials

Preparation Products


Methylisothiazolinone Suppliers

Global( 318)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Qinmu Fine Chemical Co.,Ltd.
18660799346 18363098612
+86 531 8316 6650 sales@qinmuchem.com CHINA 1009 58
NANJING SUNSHINE BIOTECH CO.,LTD
+86-25-86189929
+86-25-86189616 brian@sunshine-bio.com CHINA 128 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880623
022-66880086 sales@tjzxchem.com CHINA 537 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5429 58

View Lastest Price from Methylisothiazolinone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 2-Methyl-4-Isothiazolin-3-one
2682-20-4
US $1.36 / g 100g 99 3000KG Wuhan wingroup Pharmaceutical Co., Ltd
2021-10-19 2-Methyl-4-Isothiazolin-3-one
2682-20-4
US $50.00 / ASSAYS 1ASSAYS 99% 100ton Shanghai Yunao International Trade Co., Ltd
2021-09-07 2-Methyl-4-Isothiazolin-3-one
2682-20-4
US $0.00 / Kg/Drum 1KG 99.9% 100000kg per month Wuhan Mulei New Material Technology Co. Ltd

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