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1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE structure

CAS No.: 287471-30-1

Chemical Name:: 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE

Synonyms: 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE;Terbinafine Impurity 45;Terbinafine Impurity 22;1-Chloro-6,6-dimethyl-2-hepten-4-yne;2-HEPTEN-4-YNE,1-CHLORO-6,6-DIMETHYL;1-Chloro-6,6-dimethyl-2-hepten-4-ino;(E)-1-chloro-6,6-diMethylhept-2-en-4-yne;(2E)-1-chloro-6,6-dimethylhept-2-en-4-yne;1-CHLORO-6,6-DIMETHYL-2-ENE-4-YNE-HEPTANE;2-HEPTEN-4-YNE, 1-CHLORO-6,6-DIMETHYL-, (2E)-

CBNumber:: CB0198486

Molecular Formula:: C9H13Cl

Molecular Weight:: 156.65

MDL Number:: MFCD04039160

MOL File:: 287471-30-1.mol

MSDS File:: SDS

Last updated:2023-12-07 13:00:17

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1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Properties

Boiling point	207.5±23.0 °C(Predicted)
Density	0.946±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere, 2-8°C
InChI	InChI=1S/C9H13Cl/c1-9(2,3)7-5-4-6-8-10/h4,6H,8H2,1-3H3/b6-4+
InChIKey	ZIXABMZBMHDFEZ-GQCTYLIASA-N
SMILES	C(Cl)/C=C/C#CC(C)(C)C
CAS DataBase Reference	287471-30-1(CAS DataBase Reference)

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	HCH0036879	(2E)-1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 95.00%	287471-30-1	25G	$1404.36	2021-12-16	Buy

Product number	Packaging	Price	Buy
HCH0036879	25G	$1404.36	Buy

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Chemical Properties,Uses,Production

Description

1-Chloro-6,6-dimethyl-2-hepten-4-yne is the allylamine antifungal agents terbinafine intermediate.1-Chloro-6,6-dimethyl-2-hepten-4-yne choose to inhibit COX-fungal squalene, so that reduction of membrane ergosterol, thus inhibiting the growth of fungi play an inhibitory role; right ergosterol synthesis of precursors and no inhibitory effect on other stages.

Uses

1-Chloro-6,6-dimethyl-2-heptene-4-yne is a hydrocarbon derivative and can be used as a pharmaceutical intermediate.

Application

1-Chloro-6,6-dimethyl-2-hepten-4-yne is a chlorinating agent that has been used to minimise hydrochloric acid by converting it to chloride. It is also used in the chlorination of magnesium and other metals. 1-Chloro-6,6-dimethyl-2-hepten-4-yne has been shown to be an effective antifungal agent against dermatophytes such as Trichophyton rubrum and Microsporum canis. The compound is toxic to humans and animals because it produces acrolein and terbinafine during chlorination. It also produces hydrochloric acid as a by-product of chlorination.

Synthesis

1-Chloro-6,6-dimethyl-2-hepten-4-yne mainly due to keratin aggregation produce squalene, was squalene cyclooxygenase inhibition, squalene in the cells of a large number gathered in the form of lipid droplets penetrate fungal cell membrane, destruction of the membrane lipid composition, resulting in fungal death. A typical procedure for preparing of 1-chloro-6,6-dimethyl-2-hepten-4-yne using boron trichloride is as follows: Compound 1 (53 g, 0.38 mol) in 2800 mL of n-hexane was cooled to 10??15??. Boron trichloride (1 M in hexane, 480 mL, 0.48 mol) was added to the mixture at 15??20?? over a 10 min period. After 10 min of stirring at 20??, the mixture was quenched with 1000 mL of water and stirred for 10 min. The separated organic phase was washed with 20% NaCl, dried (MgSO4), and evaporated to afford the title compound 2 (57.1 g, 95%) in 9:1 E:Z ratio. Synthesis_287471-30-1

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Preparation Products And Raw materials

Raw materials

Preparation Products

Terbinafine Hydrochloride

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Suppliers

Global( 159)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2995	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1320	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

Supplier	Advantage
shandong perfect biotechnology co.ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
career henan chemical co	58
Xi'an Kono chem co., Ltd.,	58
Chongqing Chemdad Co., Ltd	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58

1-Chloro-6,6-dimethyl-2-hepten-4-yne: Uses; Preparation
1-Chloro-6,6-dimethyl-2-hepten-4-yne is the allylamine antifungal agents terbinafine intermediate.1-Chloro-6,6-dimethyl-2-hept....
Nov 1，2019

View Lastest Price from 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-12	1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1	US $0.00 / kg	1kg	99% HPLC	100 kgs	shandong perfect biotechnology co.ltd
2021-08-12	1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1	US $7.00 / kg	1kg	99%	100KG	Career Henan Chemical Co

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
287471-30-1
US $0.00 / kg
99% HPLC
shandong perfect biotechnology co.ltd

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
287471-30-1
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
287471-30-1
US $7.00 / kg
99%
Career Henan Chemical Co

287471-30-1(1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE)Related Search:

Terbinafine Hydrochloride 6,6-Dimethyl-1-hepten-4-yn-3-ol 1-CHLORO-6,6-DIMETHYL-2-HEPTENE-4-YNE 3,3-Dimethyl-1-butyne N-Methyl-2-naphthaMide

1-Methyl-aminomethyl naphthalene (Z)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine 1-Chloro-6,6-dimethyl-2-heptene-4-yne (E)-N,6,6-triMethyl-N-(naphthalen-2-ylMethyl)hept-2-en-4-yn-1-aMine Terbinafine

methyl-(naphthalen-2-ylmethyl)azanium N-[(2E)-6,6-DiMethyl-2-hepten-4-yn-1-yl]-N-Methyl-2-naphthaleneMethanaMine Hydrochloride cis-Terbinafine Hydrochloride (E)-1-Bromo-6,6-dimethyl-2-hepten-4-yne Chlorotrimethylsilane

chlorempenthrin

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2-HEPTEN-4-YNE, 1-CHLORO-6,6-DIMETHYL-, (2E)- 1-CHLORO-6,6-DIMETHYL-2-ENE-4-YNE-HEPTANE 1-Chloro-6,6-dimethyl-2-hepten-4-ino 2-HEPTEN-4-YNE,1-CHLORO-6,6-DIMETHYL 1-Chloro-6,6-dimethyl-2-hepten-4-yne (E)-1-chloro-6,6-diMethylhept-2-en-4-yne (2E)-1-chloro-6,6-dimethylhept-2-en-4-yne Terbinafine Impurity 22 Terbinafine Impurity 45 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1 Chemical intermediate for Terbinafine