TRIACSIN C
- CAS No.
- 76896-80-5
- Chemical Name:
- TRIACSIN C
- Synonyms
- WS1228A;FR-900190;TRIACSIN C;2,4,7-Undecatrienal;Triacsincapprox.90%;Antibiotic WS-1228A;Antibiotic FR-900190;from Streptomyces aureofaciens;2E,4E,7E-undecatriene-1-triazine;triacsin c from streptomyces sp.
- CBNumber:
- CB0199054
- Molecular Formula:
- C11H17N3O
- Molecular Weight:
- 207.27
- MDL Number:
- MFCD00798237
- MOL File:
- 76896-80-5.mol
- MSDS File:
- SDS
| Boiling point | 320.7±45.0 °C(Predicted) |
|---|---|
| Density | 0.94±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | methanol: soluble4.90 - 5.10 mg/mL, clear (Pale yellow to yellow) |
| form | Liquid. In DMSO. |
| pka | -0.10±0.70(Predicted) |
| color | clear (Pale yellow to yellow) Solution in DMSO |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions further diluted with DMSO may be stored at -20° for up to 2 months. |
| FDA UNII | 6M6D4602I5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280 |
| WGK Germany | 3 |
| HS Code | 29299090 |
TRIACSIN C price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T4540 | Triacsin C from Streptomyces sp. | 76896-80-5 | 1mg | $636 | 2024-03-01 | Buy |
| Cayman Chemical | 10007448 | Triacsin C ≥95% | 76896-80-5 | 500μg | $287 | 2024-03-01 | Buy |
| Cayman Chemical | 10007448 | Triacsin C ≥95% | 76896-80-5 | 1mg | $515 | 2024-03-01 | Buy |
| Tocris | 2472 | TriacsinC ≥95%(HPLC) | 76896-80-5 | 100U | $173 | 2021-12-16 | Buy |
| Usbiological | 256968 | Triacsin C | 76896-80-5 | 100ug | $432 | 2021-12-16 | Buy |
TRIACSIN C Chemical Properties,Uses,Production
Description
Triacsin C (76896-80-5) is a long-chain fatty acyl CoA synthetase inhibitor (IC50=3.6-8.7 μM).1?Inhibits mouse macrophage-derived foam cell formation2 and displays anti-atherosclerotic activity3. Cell permeable.
Chemical Properties
Solid
Uses
Triacsin, a fatty acyl CoA synthetase inhibitor, reduces myocardial infarct size, attenuates loss of post-reperfusion cardiac function, increases intravascular nitric oxide (NO) concentration, and inhibits leukocyte recruitment. Triacsin C analogs can also be used as potential antivirals against rotavirus infections.
Definition
ChEBI: Triacsin C is a nitroso compound that is N-undecylnitrous hydrazide carrying double bonds at positions 1,2,4, and 7. It is a long-chain fatty acyl CoA synthetase inhibitor and interferes with lipid metabolism by inhibiting the de novo synthesis of glycerolipids and cholesterol esters. It has a role as an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor, a vasodilator agent, an apoptosis inhibitor, a bacterial metabolite, an EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor and an antimalarial. It is a nitroso compound, an olefinic compound and a hydrazone.
General Description
Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common N-hydroxytriazene moiety at the terminus.
Biochem/physiol Actions
Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.
storage
Store at -20°C
References
1) Hartman et al. (1989), Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase; Prostaglandins, 37 655 2) Namatame et al. (1999), Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C; J. Biochem, 125 319 3) Matsuda et al. (2008), Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor; J. Antibiot. (Tokyo), 61 318
TRIACSIN C Preparation Products And Raw materials
Raw materials
Preparation Products
TRIACSIN C Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| R&D Scientific Inc. | +12266000236 | sales@rdscientific.com | Canada | 1218 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |