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Z-VAD-FMK

Z-VAD-FMK
Z-VAD-FMK structure
CAS No.
187389-52-2
Chemical Name:
Z-VAD-FMK
Synonyms
Z-VAD-FMK;HGNC:1504;Z-VAD(OME)-FMK;Z-VA(OME)D-FMK;Z-VADC(OME)-FMK;Z-VAD-FMK, >=98%;Z-VAL-ALA-ASP-FMK;CASPASE INHIBITOR I;CASPASE-1, INHIBITOR;CASPASE INHIBITOR VI
CBNumber:
CB0203438
Molecular Formula:
C21H28FN3O7
Formula Weight:
453.46
MOL File:
Mol file

Z-VAD-FMK Properties

Density 
1.214±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:
396.7℃
storage temp. 
−20°C
solubility 
DMSO: 20 mg/mL
form 
powder
color 
white
InChIKey
MIFGOLAMNLSLGH-QOKNQOGYSA-N
CAS DataBase Reference
187389-52-2
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25
WGK Germany  3
HS Code  29145090

Z-VAD-FMK price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 627610 Caspase Inhibitor I 187389-52-2 1mg $239 2018-11-20 Buy
Sigma-Aldrich 627610 Caspase Inhibitor I 187389-52-2 5mg $501 2018-11-20 Buy
Cayman Chemical 14463 Z-VAD(OMe)-FMK ≥95% 187389-52-2 1mg $99 2018-11-13 Buy
Cayman Chemical 14463 Z-VAD(OMe)-FMK ≥95% 187389-52-2 5mg $421 2018-11-13 Buy

Z-VAD-FMK Chemical Properties,Uses,Production

Uses

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]

Biological Activity

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .

Enzyme inhibitor

This tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.

Z-VAD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products


Z-VAD-FMK Suppliers

Global( 87)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 1954 58
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29955 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 469 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 30864 58
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
021-33632979 zijuecai@targetmol.com China 2994 58
Shanghai BRILLIA Pharmaceutical Co., Ltd 021-60448595 15601794377
021-60448595 derek1229@163.com China 59 58
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2926 55
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15881 69

View Lastest Price from Z-VAD-FMK manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-21 Z-VAD-FMK
187389-52-2
US $1.00 / KG 1G 98% 100KG career henan chemical co

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