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Z-VAD-FMK

Z-VAD-FMK
Z-VAD-FMK structure
CAS No.
187389-52-2
Chemical Name:
Z-VAD-FMK
Synonyms
CS-2005;CS-1507;Z-VAD-FMK;HGNC:1504;Z-VAD(OME)-FMK;Z-VA(OME)D-FMK;Z-VADC(OME)-FMK;Z-VAD-FMK, >=98%;Z-VAL-ALA-ASP-FMK;CASPASE INHIBITOR I
CBNumber:
CB0203438
Molecular Formula:
C22H30FN3O7
Formula Weight:
467.49
MOL File:
Mol file

Z-VAD-FMK Properties

Boiling point:
732.4±60.0 °C(Predicted)
Density 
1.214±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:
396.7℃
storage temp. 
-20°C
solubility 
DMSO: 20 mg/mL
form 
powder
pka
11.05±0.46(Predicted)
color 
white
InChIKey
MIFGOLAMNLSLGH-QOKNQOGYSA-N
CAS DataBase Reference
187389-52-2
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25
WGK Germany  3
HS Code  29145090

Z-VAD-FMK price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 627610 Caspase Inhibitor I 187389-52-2 1mg $249 2020-08-18 Buy
Sigma-Aldrich SAB2501669 Anti-CASP3 antibody produced in goat affinity isolated antibody, buffered aqueous solution 187389-52-2 100 μg $460 2021-03-22 Buy
Sigma-Aldrich 627610 Caspase Inhibitor I 187389-52-2 5mg $521 2020-08-18 Buy
Sigma-Aldrich V116 Z-VAD-FMK solid 187389-52-2 2 mg $682 2021-03-22 Buy
Cayman Chemical 14463 Z-VAD(OMe)-FMK ≥95% 187389-52-2 5mg $421 2021-03-22 Buy

Z-VAD-FMK Chemical Properties,Uses,Production

Uses

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]

Biological Activity

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .

Enzyme inhibitor

This tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.

Z-VAD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products


Z-VAD-FMK Suppliers

Global( 147)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 2462 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58

View Lastest Price from Z-VAD-FMK manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-06 Z-VAD-FMK
187389-52-2
US $1.00 / KG 1G 98% 100KG career henan chemical co

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