AM 404
- CAS No.
- 198022-70-7
- Chemical Name:
- AM 404
- Synonyms
- AM 404;Zinc03871503;N-arachidonoylaminophenol;AM 404 (in Tocrisolve 100);AM 404 (in Tocrisolve(TM) 100);N-(4-HYDROXYPHENYL)-ARACHIDONAMIDE;N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE;N-(4-HYDROXYPHENYL) ARACHIDONOYLAMIDE;ARACHIDONOYLAMIDE, N-(4-HYDROXYPHENYL);N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE \ AN
- CBNumber:
- CB0205078
- Molecular Formula:
- C26H37NO2
- Molecular Weight:
- 395.58
- MDL Number:
- MFCD03095721
- MOL File:
- 198022-70-7.mol
| storage temp. | −20°C |
|---|---|
| solubility | ethanol: 24 mg/mL Photosensitive solution. |
| form | solution |
| color | White |
| Sensitive | Air Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Compound is subject to oxidation, store under inert gas to protect from exposure to air. Solutions in DMSO or ethanol may be stored under nitrogen or argon at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Hazard Codes | F,Xi |
|---|---|
| Risk Statements | 36/37/38 |
| Safety Statements | 7-16-36-26 |
| RIDADR | UN 1170 3/PG 2 |
| WGK Germany | 1 |
AM 404 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J67201 | AM-404, 98% | 198022-70-7 | 10mg | $95.8 | 2021-12-16 | Buy |
| AK Scientific | 0045CQ | N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide | 198022-70-7 | 5mg | $125 | 2021-12-16 | Buy |
| AK Scientific | 0045CQ | N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide | 198022-70-7 | 10mg | $148 | 2021-12-16 | Buy |
| ApexBio Technology | B6604 | AM404 | 198022-70-7 | 10mg | $153 | 2021-12-16 | Buy |
| ApexBio Technology | B6604 | AM404 | 198022-70-7 | 50mg | $646 | 2021-12-16 | Buy |
AM 404 Chemical Properties,Uses,Production
Description
AM-404 (198022-70-7) inhibits anandamide transport (IC50?= 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2?Vanilloid receptors are activated by AM-404.3?Active?in vivo.1
Biological Activity
Competitive and selective inhibitor of carrier-mediated anandamide transport (IC 50 = 1 μ M). Does not activate CB 1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC 50 = 7.4). Active in vivo . Also available in water soluble emulsion (N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).
References
1) Calignano?et al. (1997),?Potentiation of anandamide hypotension by the transport inhibitor AM404; Eur. J. Pharmacol.,?337?R1 2) Beltramo?et al. (1997), Functional role of high-affinity anandamide transport, as revealed by selective inhibition; Science,?277?1094 3) Zygmunt?et al. (2000),?The anandamide inhibitor AM404 activates vanilloid receptors: Eur. J. Pharmacol.?396?39
AM 404 Preparation Products And Raw materials
Raw materials
Preparation Products
AM 404 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |