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Etidronate disodium

CAS No.
7414-83-7
Chemical Name:
Etidronate disodium
Synonyms
Etidron;sm-5600;Calcimux;Didronel;didronelr;BA 49280E;ETIDRONATE;Sodium etidronate;sodiumethidronate;sodiumethydronate
CBNumber:
CB0207300
Molecular Formula:
C2H9NaO7P2
Molecular Weight:
230.02
MDL Number:
MFCD00152567
MOL File:
7414-83-7.mol
MSDS File:
SDS
Last updated:2024-03-18 17:23:41

Etidronate disodium Properties

Melting point >300 °C
storage temp. 15-25°C
solubility H2O: 26 mg/mL
form solid
color white
Water Solubility Soluble in water (26 mg/ml).
Merck 14,3863
Stability Hygroscopic
CAS DataBase Reference 7414-83-7
EWG's Food Scores 1-2
NCI Dictionary of Cancer Terms etidronate
FDA UNII M16PXG993G
EPA Substance Registry System Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt (7414-83-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36/37/39
WGK Germany  1
RTECS  SZ8562240
TSCA  Yes
HS Code  29319090
NFPA 704
0
2 0

Etidronate disodium price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P5248 Etidronate disodium hydrate ≥97% (NMR), solid 7414-83-7 10mg $129 2024-03-01 Buy
Sigma-Aldrich 1268502 Etidronate disodium hydrate United States Pharmacopeia (USP) Reference Standard 7414-83-7 200mg $377 2022-05-15 Buy
TCI Chemical D4159 Disodium Etidronate Hydrate >98.0%(T) 7414-83-7 5g $179 2024-03-01 Buy
TCI Chemical D4159 Disodium Etidronate Hydrate >98.0%(T) 7414-83-7 25g $537 2024-03-01 Buy
Alfa Aesar J62381 Etidronate disodium 7414-83-7 1g $234.65 2024-03-01 Buy
Product number Packaging Price Buy
P5248 10mg $129 Buy
1268502 200mg $377 Buy
D4159 5g $179 Buy
D4159 25g $537 Buy
J62381 1g $234.65 Buy

Etidronate disodium Chemical Properties,Uses,Production

Description

Agents in the first generation (e.g., etidronate disodium and tiludronate) that were dosed continuously produced poorly mineralized bone, because there was no interval for appropriate bone mineralization to occur. Subsequent studies that used a cyclic dosing schedule (400 mg/day for 2 weeks, followed by 2.5 months of calcium supplementation only) showed improvement in bone mineralization. Etidronate has been approved for treatment of Paget's disease of the bone but not for treatment of osteoporosis. Tiludronate is approximately 10-fold more potent than etidronate and, when given orally for 6 months (200, 400, or 800 mg/day), increases BMD by 2%. No further bone loss was detected in patients 6 months after cessation of therapy.

Chemical Properties

White Crystalline Solid

Originator

Etidron,Gentili,Italy,1977

Uses

Sequestering and chelating agent; scale and corrosion inhibitor.

Uses

progestin

Uses

Used as a calcium regulator. A bisphosphonate bone resorptive inhibitor

Uses

Etidronate disodium is a bisphosphonate antiresorptive agent,it is used as a calcium regulator.

Definition

ChEBI: An organic sodium salt resulting from the replacement of two protons from etidronic acid (one from from each of the phosphonic acid groups) by sodium ions.

Manufacturing Process

Phosphorous acid was premixed with acetic acid to form a 50 wt % solution of phosphorous acid dissolved in acetic acid. The acids were mixed on a molar basis of 1.36:1, acetic acid to phosphorous acid, and this corresponded on a mol percentage basis to 57.6% acetic acid and 42.4% phosphorous acid. Acetic anhydride was continuously metered into a stream of the phosphorous acid-acetic acid mixture to form the reaction solution. The acetic anhydride was metered into the acid mixture at a mol ratio of 1.33 mols of acetic anhydride per mol of phosphorous acid. The metering rates were 18.5 lb/hr of the phosphorous acid/acetic acid premixed solution and 15.1 lb/hr acetic anhydride. The reaction solution was continuously passed through a heat exchanger where it was heated to 190°F then it was continuously fed into a two stage back-mix reaction zone where due to the heat of reaction the temperature rose to 275°F. The average residence in the reaction zone was 27 min. The reaction zone consisted of two back-mix reactors each having a capacity of 7.5 pounds of the reaction solution. A stream of reaction solution was continuously with drawn from the second reactor and continuously mixed with a stream of water which was being metered at a rate of 2 lb/hr. This amount of water corresponded to 18% excess over the theoretical amount necessary to hydrolyze all of the acetyl-containing compounds in the reaction solution to free acids. The hydrolyzed solution was continuously passed through a heat exchanger and cooled to room temperature after which the solution was continuously passed to a crystallizer where, with agitation, the ethane-1-hydroxy-1,1-diphosphonic acid crystallized. The slurry was then filtered and the crystals were recovered and dried. Analysis of the product showed a conversion rate of phosphorous acid to ethane-1-hydroxy-1,1- diphosphonic acid of 86%. Sodium hydroxide may be used to give the disodium salt.

brand name

Didronel (Millot Laboratories, France); Didronel (Procter & Gamble).

Therapeutic Function

Bone calcium regulator

Biochem/physiol Actions

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.

Safety Profile

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of POx, and Na2O.

Veterinary Drugs and Treatments

Etidronate is a first generation bisphosphonate that may be useful for the treatment of severe hypercalcemia associated with neoplastic disease. Its use in human medicine has been largely replaced with newer, more potent bisphosphonates that can be dosed less often or have fewer adverse effects. Etidronate is also indicated in humans for the treatment of Paget’s disease and heterotopic ossification (e.g., after total hip replacement).

Etidronate disodium Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 343)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
+86-0086-025-69916489 +86-18852044786 tongyuansales@vip.sina.com China 323 58
Shanghai Affida new material science and technology center
+undefined15081010295 2691956269@qq.com China 350 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14936 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
Tianjin Zhongxin Chemtech Co., Ltd.
+86-022-66880623 +8618622897568 sales@tjzxchem.com China 558 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Jinan Finer Chemical Co., Ltd
+86-531-88989536 +86-15508631887 sales@finerchem.com China 2966 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58

View Lastest Price from Etidronate disodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Etidronate disodium pictures 2024-03-18 Etidronate disodium
7414-83-7
US $0.00-0.00 / KG 1KG 99 10 tons Shanghai Affida new material science and technology center
Etidronate Disodium pictures 2023-03-06 Etidronate Disodium
7414-83-7
US $19.10 / KG 1KG 99% 10 ton Hebei Guanlang Biotechnology Co,.LTD
Etidronate disodium pictures 2021-09-29 Etidronate disodium
7414-83-7
US $0.00 / Kg/Drum 1KG 98%min; CP 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
  • Etidronate disodium pictures
  • Etidronate disodium
    7414-83-7
  • US $0.00-0.00 / KG
  • 99
  • Shanghai Affida new material science and technology center
Sodium etidronate didronelr disodium(1-hydroxyethylidene)diphosphonate disodium1-hydroxyethylidenephosphonate disodiumdihydrogen(1-hydroxyethylidene)diphosphonate disodiumethanol-1,1-diphosphonate disodiumethydronate 1-Hydroxyethylidone-1,1-diphosphonicaciddisodiumsalt 1-Hydroxyethylidone-1,1-diphosphonicacidpentasodiumsalt Pentasodiumetidronate 1-Hydroxyethylidone-1,1-diphosphonicacid 1-Hydroxyethylidone-1,1-diphosphonicacidtrisodiumsalt Calcimux Etidron DIPHOSPHONICACID,(1-HYDROXYETHYLENE)-,DISODIUMSALT DIPHOSPHONICACID,(1-HYDROXYETHYLIDENE)-,DISODIUMSALT etidronate disodium,ETD Dinatriumdihydrogen(1-hydroxyethyliden)bisphosphonat 1-Hydroxyethylidene-1,1-bis-(phosphonic acid) disodium salt Phosphonicacid, P,P'-(1-hydroxyethylidene)bis-, sodiuM salt (1:2) DisodiuM of 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid (HEDPNa2) Etidronate Disodium (200 mg) (1-Hydroxyethane-1,1-diyl)diphosphonic acid disodi Didronel disodium hydroxy-[1-hydroxy-1-[hydroxy(oxidanidyl)phosphoryl]ethyl]phosphinate disodium hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate DisodiuM Etidronate Hydrate 1-Hydroxyethane-1,1-diphosphonic Acid DisodiuM Salt BA 49280E DisodiuM (1-Hydroxyethylidene)-1,1-bisphosphonate P,P'-(1-Hydroxyethylidene)bisphosphonic Acid SodiuM Salt Disodium 1-Hydroxyethane-1,1-diphosphonate 1-Hydroxyethane-1,1-diphosphonic Acid Disodium Salt Etidronic Acid Disodium Salt Etidronate disodiuM hydrate DIHYDROGEN (1-HYDROXYETHYLIDENE)BISPHOSPHONATE DISODIUM DISODIUM ETIDRONATE hedp disodium salt ETIDRONATE ETIDRONATE DISODIUM Etidronic acid disodium salt ETRIDRONIC ACID, DISODIUM SALT 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID DISODIUM SALT (1-HYDROXYETHYLIDENE)BISPHONIC ACID (1-HYDROXYETHYLIDENE)BISPHOSPHONIC ACID (1-hydroxyethane-1,1-diyl)diphosphonicaciddisodiumsalt (1-hydroxyethane-1,1-diyl)di-phosphonicacidisodiumsalt (1-hydroxyethylidene)bis-phosphonicacidisodiumsalt (1-hydroxyethylidene)diphosphonicacid,disodiumsalt (1-hydroxyethylidene)di-phosphonicacidisodiumsalt ethane-1-hydroxy-1,1-diphosphonicacid,disodiumsalt Phosphonicacid,(1-hydroxyethylidene)bis-,disodiumsalt sm-5600 sodiumethidronate sodiumethydronate ethydronate disodium ETIDRONATE DISODIUM (1-HYDROXYETHYLIDONE-1,1-DIPHOSPHONIC ACID DISODIUM SALT) ETIDRONATE DISODIUM USP(CRM STANDARD) Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate disodium dihydrogen (1-hydroxyethylidene)bisphosphonate