Palonosetron Hydrochloride

Palonosetron Hydrochloride Properties

Melting point	>290°C
alpha	D25 -94.1° (c = 0.4 in water)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Methanol (Slightly, Heated), Water (Slightly)
form	Solid
color	White to Off-White
Merck	14,6997
InChI	InChI=1/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/s3
InChIKey	OLDRWYVIKMSFFB-HYCRUXCXNA-N
SMILES	N1(C[C@@]2([H])CCCC3=CC=CC(=C32)C1=O)[C@H]1[C@]2([H])CCN(CC2)C1.Cl \|&1:2,15,16,r\|
CAS DataBase Reference	135729-62-3(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	Aloxi; palonosetron hydrochloride
FDA UNII	23310D4I19
NCI Drug Dictionary	Aloxi

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H332-H302-H312
Precautionary statements	P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312
HS Code	29339900

Palonosetron Hydrochloride price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P2051	Palonosetron Hydrochloride >98.0%(HPLC)(T)	135729-62-3	200mg	$215	2024-03-01	Buy
TCI Chemical	P2051	Palonosetron Hydrochloride >98.0%(HPLC)(T)	135729-62-3	1g	$741	2024-03-01	Buy
Cayman Chemical	16752	Palonosetron (hydrochloride) ≥98%	135729-62-3	5mg	$73	2024-03-01	Buy
Cayman Chemical	16752	Palonosetron (hydrochloride) ≥98%	135729-62-3	10mg	$131	2024-03-01	Buy
Cayman Chemical	16752	Palonosetron (hydrochloride) ≥98%	135729-62-3	50mg	$359	2024-03-01	Buy

Product number	Packaging	Price	Buy
P2051	200mg	$215	Buy
P2051	1g	$741	Buy
16752	5mg	$73	Buy
16752	10mg	$131	Buy
16752	50mg	$359	Buy

Palonosetron Hydrochloride Chemical Properties,Uses,Production

Nausea and vomiting drug

Palonosetron hydrochloride is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention.
With 1,2,3,4-tetrahydro-1-naphthoic acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.
Clinical studies showed that palonosetron can be used safely with corticosteroids, analgesics, antiemetics, antispasmodics and anticholinergic drugsas the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.
Murine tumor model studies indicate that palonosetron does not inhibit the five kinds of chemotherapy drugs studied (cisplatin, cyclophosphamide, cytarabine, doxorubicin and mitomycin C) anti-cancer activity.

Adverse effects

The most common adverse effects are headache, which occurs in 4–11% of patients, and constipation in up to 6% of patients. In less than 1% of patients, other gastrointestinal disorders occur, as well as sleeplessness, first-and second-degree atrioventricular block, muscle pain and shortness of breath. Palonosetron is similarly well tolerated as other setrons, and slightly less than placebo.

References

https://en.wikipedia.org/wiki/Palonosetron

Description

Palonosetron is a novel 5-HT3 receptor antagonist launched as an injectable agent for the prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy. It has a much longer half-life (～ 40 h) than the other currently available 5-HT3 antagonists, which provides efficacy advantages in the prevention of delayed nausea and vomiting that typically occurs after 24 h and up to six days post chemotherapy administration. Palonosetron was developed as a conformationally restricted analog of the previously known 5HT3 antagonists tropisetron and granisetron. It is synthesized in four steps starting with the condensation of 1,8- naphthalic anhydride and (S)-3-aminoquinuclidine to produce the corresponding imide. The subsequent steps include catalytic hydrogenation of one of the aromatic rings of the imide intermediate, selective reduction of one of the carbonyls to a hydroxyl group, dehydration to an olefin and catalytic hydrogenation. The recommended dosage of palonosteron is 0.25 mg, administered as a single intravenous dose approximately 30 min before the start of chemotherapy. Palonosetron exhibits dose-proportional pharmacokinetics and it is moderately bound to plasma proteins (62%). Fifty percent of the dose is metabolized in the liver, and 40% is excreted unchanged in the urine. In comparative clinical studies with two other 5- HT3 receptor antagonists, palonosetron is shown to be as effective as dolasetron and more effective than ondansetron in controlling acute nausea and vomiting and superior to both in the control of delayed nausea and vomiting. Efficacy of palonosetron has been demonstrated in patients receiving initial and repeat courses of both moderately and highly emetogenic chemotherapy, including cisplatin, cyclophosphamide and dacarbazine. At 0.25 and 0.75 mg doses, palonosetron is well tolerated and the most occurring adverse events are headache, diarrhea, fatigue, abdominal pain and insomnia.

Chemical Properties

White Solid

Originator

Syntex (Roche Bioscience) (US)

Uses

(S,S)-Palonosetron Hydrochloride is a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.

Uses

Palonosetron is a potent, selective antagonist of the serotonin (5-HT) receptor 5-HT3 (pKi = 10.4 in rat cortex) that minimally effects a wide range of other neuronal receptors. It is orally bioavailable and potently inhibits emesis induced by chemotherapeutic drugs, like cisplatin , but not by apomorphine , which acts by dopamine receptor antagonism. Palonosetron is remarkable for its long duration of action, related to its high receptor-binding affinity and long half-life. It is effective in managing chemotherapy-induced nausea and vomiting.[Cayman Chemical]

Uses

specifically inhibits cells of the adrenal cortex and their production of hormones for adrenocortical tumor therapy, causes CNS damage, but no bone marrow depression.

Uses

Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting

Definition

ChEBI: A hydrochloride obtained by combining palonosetron with one molar equivalent of hydrogen chloride; an antiemetic used in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.

brand name

Aloxi (Helsinn).

storage

Store at -20°C

Palonosetron Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Palonosetron Hydrochloride Suppliers

Global( 494)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd	+86-02223869539 +86-15560057295	trade.kilopharma@foxmail.com	China	27	58
Zibo Wei Bin Import & Export Trade Co. Ltd.	+86-0533-2091136 +8613864437655	ziboweibinmaoyi@163.com	China	100	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9350	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58

Supplier	Advantage
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd	58
Zibo Wei Bin Import & Export Trade Co. Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
shandong perfect biotechnology co.ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Lianyungang happen teng technology co., LTD	58

View Lastest Price from Palonosetron Hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-07	Palonosetron Hydrochloride 135729-62-3	US $428.70 / kg	1kg	99%	1t	Zibo Wei Bin Import & Export Trade Co. Ltd.
2024-03-12	Palonosetron hydrochloride 135729-62-3	US $0.00 / g	1g	98% HPLC	100kg	shandong perfect biotechnology co.ltd
2023-09-06	Palonosetron Hydrochloride 135729-62-3	US $0.00 / KG	1KG	99%	500000kg	Hebei Guanlang Biotechnology Co., Ltd.

Palonosetron Hydrochloride
135729-62-3
US $428.70 / kg
99%
Zibo Wei Bin Import & Export Trade Co. Ltd.

Palonosetron hydrochloride
135729-62-3
US $0.00 / g
98% HPLC
shandong perfect biotechnology co.ltd

Palonosetron Hydrochloride
135729-62-3
US $0.00 / KG
99%
Hebei Guanlang Biotechnology Co., Ltd.

Palonosetron Hydrochloride Spectrum

Palonosetron Hydrochloride(135729-62-3)¹HNMR

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Palonosetron PALONOSETRON HCL,(3as)-2-(3s)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1h-benz[de]isoquinolin-1-one monohydrochloride 2-(piperidin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline

1of4

PALONOSETRON HYDROCHLORIDE (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride Onicit RS-25259-197 (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochloride (S,S)-Palonosetron Hydrochloride (S,S)-Palonosetron HCl (3aS)-2-[(S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride Palonosetron Hydrochloride API 1H-Benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, hydrochloride (1:1), (3aS)- RS 25259 (S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride Palonosetron hydrochloride, >=99% Palonosetron hydrochloride, 99.5%, a 5-HT3 antagonist CS-292 Palonosetronhydrochloride hydrochloride Palonosetron-d3 HCl PalonosetronHydrochloride> (S)-8-((((S)-quinuclidin-3-yl)amino)methyl)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid Palonosetron Hydrochloride USP/EP/BP a 5-HT3 antagonist PalnosetronHcl Palonosetron HCl (RS25233-197 (5S)-3-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3-azatricyclo[7.3.1.?,13]trideca-1(13),9,11-trien-2-one hydrochloride Palonosetron Hydrochloride (1492200) Methylisothiazolinone free base (S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5 PALONOSETRON HCL Aloxi Palonosetron HCI 135729-62-3 C19H24N2OHCl C19H25ClN2O C19H24N2OHC Selective 5-HT3 Receptor Antagonist Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals API 135729-62-3