ChemicalBook >> CAS DataBase List >>2-Methylpyrazine


Chemical Name:
Pyrazine, methyl-;METHYLPYRAZINE;3-Methylpyrazine;2-METHYL-1,4-DIAZINE;MPZ;FEMA 3309;FEMA 3616;Methylpiazine;methyl-pyrazin;FEMA NUMBER 3309
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
Last updated:2024-02-23 12:06:14

2-Methylpyrazine Properties

Melting point -29 °C (lit.)
Boiling point 135 °C/761 mmHg (lit.)
Density 1.03 g/mL at 25 °C (lit.)
refractive index n20/D 1.504(lit.)
Flash point 122 °F
storage temp. 2-8°C
solubility >20.87 mg/mL in EtOH with ultrasonic; >49.9 mg/mL in DMSO;
pka 1.45(at 27℃)
form Liquid
color Clear colorless to slightly yellow
Odor at 1.00 % in dipropylene glycol. nutty cocoa roasted chocolate peanut green
Odor Type nutty
Water Solubility Fully miscible in water.
JECFA Number 761
BRN 105778
LogP 0.18
CAS DataBase Reference 109-08-0(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 2-METHYLPYRAZINE
EWG's Food Scores 1
NIST Chemistry Reference Pyrazine, methyl-(109-08-0)
EPA Substance Registry System Pyrazine, methyl- (109-08-0)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
Signal word  Warning
Hazard statements  H226-H302
Precautionary statements  P210-P233-P240-P241-P242-P301+P312
Hazard Codes  Xn,Xi,F
Risk Statements  10-22-36/37/38
Safety Statements  26-36-16
RIDADR  UN 1993 3/PG 3
WGK Germany  3
RTECS  UQ3675000
HazardClass  3
PackingGroup  III
HS Code  29339990
Toxicity mouse,LD50,intraperitoneal,1820mg/kg (1820mg/kg),Toxicology and Applied Pharmacology. Vol. 17, Pg. 244, 1970.
NFPA 704
2 0

2-Methylpyrazine price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W330906 2-Methylpyrazine ≥99%, FCC, FG 109-08-0 100g $87.4 2023-06-20 Buy
Sigma-Aldrich W330906 2-Methylpyrazine ≥99%, FCC, FG 109-08-0 1kg $175 2023-06-20 Buy
Sigma-Aldrich W330906 2-Methylpyrazine ≥99%, FCC, FG 109-08-0 5kg $627 2023-06-20 Buy
Sigma-Aldrich M75608 2-Methylpyrazine ≥99% 109-08-0 25g $31.2 2023-06-20 Buy
Sigma-Aldrich M75608 2-Methylpyrazine ≥99% 109-08-0 100g $54 2023-06-20 Buy
Product number Packaging Price Buy
W330906 100g $87.4 Buy
W330906 1kg $175 Buy
W330906 5kg $627 Buy
M75608 25g $31.2 Buy
M75608 100g $54 Buy

2-Methylpyrazine Chemical Properties,Uses,Production


2-Methylpyrazine has an odor threshold in water variously reported at 60,000 or 105,000 ppb. May be prepared from the corresponding carboxylic acid; by catalytic dehydrogenation of 2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine.

Chemical Properties

clear colorless to slightly yellow liquid

Chemical Properties

2-Methylpyrazine has a nutty, cocoa, green, roasted, chocolate, meaty odor.


Reported found in bakery products, roasted barley, cocoa products, coffee, dairy products, cooked meats, peanuts, filberts, pecans, popcorn, potato chips, rum and whiskey, soy product, roasted filberts, roasted almonds, guava, papaya, asparagus, kohlrabi, baked and fried potato, milk, boiled egg, smoked fish, beer, coffee, sesame seed, rice, sukiyaki, buckwheat, sweet corn, corn tortillas, malt, wort, wild rice, okra, crayfish, clam, squid and maté.


2-Methylpyrazine is used as flavoring agents in bread fresh bread, butter, chocolate, chocolate cocoa, coffee, meat roasted, nut almond.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.


From corresponding carboxylic acid; by catalytic dehydrogenation of 2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine


ChEBI: Methylpyrazine is a member of the class of pyrazines that is pyrazine in which one of the hydrogens is replaced by a methyl group. It is a flavouring agent found in coffee, peanuts and red peppers. It has a role as a flavouring agent, a plant metabolite and a Maillard reaction product.

Aroma threshold values

Detection: 60 ppb to 100 ppm

Taste threshold values

Taste characteristics at 75 ppm: nutty, brown, musty, roasted and astringent

General Description

2-Methylpyrazine is an alkyl-substituted pyrazine used as a key intermediate in the synthesis of pyrazineamide, an anti-tubercular drug.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Mutation data reported. Flammable liquid when exposed to heat, sparks, or flame. Can react with oxidizing materials. To fight fire, use water spray, foam, dry chemical, CO2. When heated to decomposition it emits highly toxic fumes of NOx.

Purification Methods

Purify it via the picrate and distil the free base. The picrate has m133-134o(from EtOH). [Wiggins & Wise J Chem Soc 4780 1956, Beilstein 23 III/IV 911, 23/5 V 386.]

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View Lastest Price from 2-Methylpyrazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methylpyrazine pictures 2024-02-24 2-Methylpyrazine
US $0.00-0.00 / kg 25kg 99% 10 tons Hebei Yanxi Chemical Co., Ltd.
2-Methylpyrazine pictures 2023-08-31 2-Methylpyrazine
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
2-Methylpyrazine pictures 2023-03-06 2-Methylpyrazine
US $10.70 / kg 10kg 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
2-methyl-1,4-diazinen 2-METHYLPYRAZINE FEMA NUMBER 3309 FEMA 3616 FEMA 3309 METHYLPYRAZINE, 2- MPZ 2-methyl-pyrazin methyl-pyrazin Pyrazine, 2-methyl- 2-METHYLPYRAZINE, 99+% 2-METHYLPYRAZINE 99+% FCC Methylpiazine methylpyrazine,2-methylpyrazine METHYLPYRAZINE, 2-(SG) 2-METHYL PYRAZINE FEMA NO.3309 2-METHYLPYRAZINE 2-METHYLPYRAZINE 2-METHYL PYRAZINE pure Methylpyrazine, 99+% 2-Methylpyrazine ,98% 2-METHYLPYRAZINE FOR SYNTHESIS 2-Methylpyrazine, 97+% 2-Methylpyrazine >=99.0% 2-Methylpyrazine, 99+ % 25GR Glucosamine Impurity 5 2-Methylpyrazine 2 2-methylpyrazine reference substance 2-methylpyrazine CRS 2-Methylpyrazine> Pyrazine Impurity 1 (2-Methylpyrazine) Recombinant Human MPZ Protein, His Tag 2-Methylpyrazine USP/EP/BP Glucosamine sulphate Impurity 5 2-METHYL-1,4-DIAZINE METHYLPYRAZINE Pyrazine, methyl- 3-Methylpyrazine 2,3-Diethyl-5-methylpyrazine 18138-04-0 Glucosamine sulfate Impurity 15 109-08-0 -NCCH3CHNCHCH Mono- & Polyalkylpyrazines Pyrazines Heterocyclic Building Blocks Building Blocks Pyrazine compounds Building Blocks Heterocyclic Building Blocks Alphabetical Listings Flavors and Fragrances M-N Mono- & Polyalkylpyrazines pyrazine Flavor Pyrazine Pyrazines