2-(Chloromethyl)thiophene
- CAS No.
- 765-50-4
- Chemical Name:
- 2-(Chloromethyl)thiophene
- Synonyms
- Thenyl chloride;2-(chloromethyl)thiophene;THIOPHENE, 2-(CHLOROMETHYL)-;2-(Chloromethyl)thiophene###765-50-4;2-(Chloromethyl)thiophene ISO 9001：2015 REACH;2-(Chloromethyl)thiophene, 33% w/w solution in toluene
- CBNumber:
- CB0238735
- Molecular Formula:
- C5H5ClS
- Molecular Weight:
- 132.61
- MDL Number:
- MFCD00797972
- MOL File:
- 765-50-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-(Chloromethyl)thiophene | B419458 | 500mg | $195 |
| 2-(Chloromethyl)thiophene | 189789 | 5g | $196 |
| 2-(Chloromethyl)thiophene | 189789 | 10g | $323 |
| 2-CHLOROMETHYLTHIOPHENE 95.00% | HCH0011564 | 5G | $514.5 |
| 2-(Chloromethyl)thiophene | 189789 | 25g | $586 |
| More product size | |||
| Boiling point | 80-81 °C(Press: 18 Torr) |
|---|---|
| Density | 1.243±0.06 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer |
| solubility | Acetonitrile, Chloroform |
| form | Oil |
| color | Colourless |
| CAS DataBase Reference | 765-50-4(CAS DataBase Reference) |
| FDA UNII | 7QQ8C6HMR7 |
| NIST Chemistry Reference | Thiophene, 2-(chloromethyl)-(765-50-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| RIDADR | 1993 |
| HazardClass | 3 |
| PackingGroup | Ⅲ |
| HS Code | 2933399990 |
2-(Chloromethyl)thiophene price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B419458 | 2-(Chloromethyl)thiophene | 765-50-4 | 500mg | $195 | 2021-12-16 | Buy |
| Matrix Scientific | 189789 | 2-(Chloromethyl)thiophene | 765-50-4 | 5g | $196 | 2021-12-16 | Buy |
| Matrix Scientific | 189789 | 2-(Chloromethyl)thiophene | 765-50-4 | 10g | $323 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0011564 | 2-CHLOROMETHYLTHIOPHENE 95.00% | 765-50-4 | 5G | $514.5 | 2021-12-16 | Buy |
| Matrix Scientific | 189789 | 2-(Chloromethyl)thiophene | 765-50-4 | 25g | $586 | 2021-12-16 | Buy |
2-(Chloromethyl)thiophene Chemical Properties,Uses,Production
Chemical Properties
Colorless Liquid
Synthesis
636-72-6
765-50-4
The general procedure for the synthesis of 2-chloromethylthiophene from 2-thiophenemethanol was as follows: 2-thiophenemethanol (5,58 g, 509 mmol) and pyridine (60 g, 763 mmol) were dissolved in 600 mL of anhydrous dichloromethane at 0 °C, and thionyl chloride was added slowly and dropwise. The reaction mixture was stirred at 0°C for 1 hour, then brought to room temperature and continued to stir overnight. Upon completion of the reaction, the reaction was quenched by the addition of 500 mL of water. The organic layer was separated and the aqueous layer was extracted twice with 300 mL of dichloromethane. The organic layers were combined and washed sequentially with 600 mL of 5% aqueous sodium bicarbonate and 300 mL of brine. The organic layer was dried with anhydrous sodium sulfate and concentrated to give 40 g of 2-chloromethylthiophene (6) as an oil in 60% yield.
References
[1] European Journal of Medicinal Chemistry, 2001, vol. 36, # 11-12, p. 873 - 886
[2] European Journal of Pharmaceutical Sciences, 2002, vol. 16, # 1-2, p. 15 - 28
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 11, p. 2365 - 2370
[4] Tetrahedron, 1998, vol. 54, # 25, p. 6999 - 7012
[5] Synthetic Communications, 2005, vol. 35, # 15, p. 2079 - 2083
2-(Chloromethyl)thiophene Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3996 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3982 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from 2-(Chloromethyl)thiophene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 2-(Chloromethyl)thiophene
765-50-4
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-12-24 | 2-(Chloromethyl)thiophene
765-50-4
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-08-12 | 2-(Chloromethyl)thiophene
765-50-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-(Chloromethyl)thiophene
765-50-4
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-(Chloromethyl)thiophene
765-50-4
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-(Chloromethyl)thiophene
765-50-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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