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Drostanolone propionate

CAS No.
521-12-0
Chemical Name:
Drostanolone propionate
Synonyms
MDHT;32379;2MDTP;Mast P;357429;Re 346;rs1567;Drolban;2M-DHTP;RS 1567
CBNumber:
CB0239590
Molecular Formula:
C23H36O3
Molecular Weight:
360.54
MDL Number:
MFCD01669961
MOL File:
521-12-0.mol
Last updated:2024-09-23 15:54:53

Drostanolone propionate Properties

Melting point 114-120°C
alpha D +24°
Boiling point 432.53°C (rough estimate)
Density 1.0669 (rough estimate)
refractive index 1.4700 (estimate)
storage temp. Controlled Substance, -20°C Freezer
solubility DMF:30.0(Max Conc. mg/mL);83.21(Max Conc. mM)
DMSO:24.0(Max Conc. mg/mL);66.57(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.55(Max Conc. mM)
form A crystalline solid
InChI InChI=1/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/s3
InChIKey NOTIQUSPUUHHEH-DEMPVMEFNA-N
SMILES C[C@]12C[C@@H](C)C(=O)C[C@]1([H])CC[C@@]1([H])[C@]3([H])CC[C@H](OC(=O)CC)[C@@]3(C)CC[C@]21[H] |&1:1,3,8,12,14,18,24,28,r|
CAS DataBase Reference 521-12-0(CAS DataBase Reference)
FDA UNII X20UZ57G4O
NIST Chemistry Reference Dromostanolone propionate(521-12-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H351-H360FD
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Toxicity LD50 subcutaneous in mouse: > 2gm/kg

Drostanolone propionate price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich NMIS025 Drostanolone propionate NMI Australia 521-12-0 20MG $191 2023-06-20 Buy
Matrix Scientific 099251 Dromostanolone propionate 95+% 521-12-0 250mg $32 2021-12-16 Buy
Matrix Scientific 099251 Dromostanolone propionate 95+% 521-12-0 1g $75 2021-12-16 Buy
American Custom Chemicals Corporation CHM0078918 DROSTANOLONE PROPIONATE 95.00% 521-12-0 100MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation CHM0078918 DROSTANOLONE PROPIONATE 95.00% 521-12-0 1G $1871.1 2021-12-16 Buy
Product number Packaging Price Buy
NMIS025 20MG $191 Buy
099251 250mg $32 Buy
099251 1g $75 Buy
CHM0078918 100MG $739.2 Buy
CHM0078918 1G $1871.1 Buy

Drostanolone propionate Chemical Properties,Uses,Production

Antiestrogenic effects

Dromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness.
Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group.Drostanolone Propionate is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone.

Physiological effect

Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle.

Description

17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate, also known as drostanolone propionate, is a synthetic anabolic-androgenic steroid. It has similar properties to dihydrotestosterone. It had been used for the treatment of breast cancer in the past. However, it is now mainly used by athletes and bodybuilder as an anabolic steroid. It has two major effects including enhancing the physical/athletic performance (such as endurance and strength) and enhancing physical health (muscle buildup and fat loss). It should be administrated via intramuscular injection instead of oral taking.

Chemical Properties

White Solid

Originator

Drolban,Lilly,US,1961

Uses

Drostanolone propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. It is used as an antineoplastic for use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal. Now it is used to help improve athletic performance and muscle gain.

Preparation

Drostanolone propionate is prepared from 9,11-dehydro-17a-methyl-testosterone raw material, reacts with lithium chloride and N-chlorosuccinimide to generate 9a,11-dichloro-17a-methyl- 95 testosterone is further prepared by esterification with propionin.

Definition

ChEBI: Drostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It is functionally related to a metholone.

Manufacturing Process

A suspension of 10 grams of dihydrotestosterone in 500 cc of anhydrous benzene free of thiophene was mixed with10 cc of ethyl formate and 3 grams of sodium hydride and the mixture was stirred for 5 hours under an atmosphere of nitrogen and at a temperature of approximately 25°C. The resulting suspension was filtered, the resulting mixture of the sodium salt of the hydroxymethylene compound and the excess of sodium hydride was washed with benzene and dried. This mixture was slowly added to a vigorously stirred solution of 20 cc of concentrated hydrochloric acid in 500 cc of water, and the stirring was continued for 30 minutes at the end of which the precipitate was collected and well washed with distilled water. After drying in vacuo, there was obtained 9.7 grams of 2-hydroxymethylenedihydrotestosterone.
A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of pyridine and 2 cc of propionic anhydride was allowed to react at room temperature for 16 hours and then poured into water. The resulting suspension was heated for 1 hour on the steam bath to hydrolyze the excess of propionic anhydride, cooled and extracted with methylene dichloride. The extract was consecutively washed with dilute hydrochloric acid, sodium bicarbonate solution and water, dried over anhydrous sodium sulfate and evaporated to dryness under vacuum. There was thus obtained the dipropionate of 2-hydroxymethylenedihydrotestosterone which was treated with hydrogen, in methanol solution.
When the uptake of hydrogen ceased, the catalyst was filtered and the solution was evaporated to dryness under vacuum. The residue was dissolved in a mixture of benzene-hexane, transferred to a chromatographic column with neutral alumina and the product was eluted with mixtures of benzenehexane, gradually increasing the proportion of benzene in the mixture. Crystallization of the eluates from acetone-hexane yielded the propionate of 2α-methyldihydrotestosterone.

brand name

Drolban (Lilly).

Therapeutic Function

Cancer chemotherapy

Side effects

As to be expected with all steroids, it's essential that you're aware of all potential side effects of Drostanolone propionate, before you consider a cycle. Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It has no risk of liver damage.

References

https://en.wikipedia.org/wiki/Drostanolone_propionate
http://www.chemspider.com/Chemical-Structure.194604.html
http://steroid.es/drostanolone.html
Chowdhury, M. S., et al. "A comparison of drostanolone propionate (Masteril) and nandrolone decanoate (Deca-durabolin) in the treatment of breast carcinoma. " 2.3(1976):203-206.

Drostanolone propionate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 245)Suppliers
Supplier Tel Email Country ProdList Advantage
.GZ HONESTCHEM CO.,LTD
+86-15013270415 +86-15013270415 honestchemical@foxmail.com China 244 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
+8615995072465 sales@xuanmingchem.com China 914 58
Hebei Linwo New Material Technology Co., LTD
+8618134091113 sales5@hblwxcl.com China 979 58
Hubei Lange Biotechnology Co., Ltd.
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Hebei Gongyuan New Material Technology Co., Ltd.
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Hebei Yinsheng Technology Co., Ltd.
+86-17331136691 lemon@hbyinsheng.com China 597 58
Hebei Shengyuan Jinlong Import and Export Co. LTD
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Anhui Zhongda Biotechnology Co., Ltd
+8615689548120 linda@zhongda-biotech.com China 193 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12835 58
Firsky International Trade (Wuhan) Co., Ltd
+8615387054039 admin@firsky-cn.com China 427 58

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View Lastest Price from Drostanolone propionate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Drostanolone Propionate  pictures 2024-11-11 Drostanolone Propionate
521-12-0
US $30.00-10.00 / kg 1kg 99% 20 hebei hongtan Biotechnology Co., Ltd
Drostanolone Propionate pictures 2024-10-23 Drostanolone Propionate
521-12-0
US $1.00 / KG 1KG 99.9% 500KG .GZ HONESTCHEM CO.,LTD
Dromostanolone propionate pictures 2024-10-23 Dromostanolone propionate
521-12-0
US $1.00 / g 1g 98% 999g Apeloa production Co.,Limited
Drostanolone propioante DroMostanolone Enanthate(Masteron) 17β-Hydroxy-2α-methyl-5α-androstan-3-one propionate 17β-Hydroxy-2α-methylandrostan-3-one propionate 2α-Methyl-17β-hydroxy-5α-androstan-3-one 17-propionate 2α-Methyl-17β-propionoxy-5α-androstan-3-one 2α-Methyl-4,5-dihydrotestosterone propionate 2α-Methylandrostan-17(β)-ol-3-one propionate 2α-Methylandrostan-17β-ol-3-one propionate 2α-Methyldihydrotestosterone propionate 5α-Androstan-3-one, 17β-hydroxy-2α-methyl-, propionate (6CI, 7CI, 8CI) Androstan-3-one, 2-methyl-17-(1-oxopropoxy)-, (2α,5α,17β)- NSC-12198 DroMostanolone Propionate(Masteron) (2R,5S,8R,9S,10S,13S,14S,17S)-2,10,13-triMethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl propionate Mast P 2-Methyl-3-oxoandrostan-17-yl propionate 2α-methyl-17β-(1-oxopropoxy)-5α-androstan-3-one 32379 357429 5alpha-Androstan-3-one, 17beta-hydroxy-2alpha-methyl-, propionate Androstan-3-one, 2-methyl-17-(1-oxopropoxy)-, (2alpha,5alpha,17beta)- Blackburn Compound Drolban Emdisterone Lilly 32379 Masterid Masteril Masterone MDHT Medrotestron propionate medrotestronepropanoate medrotestronepropionate medrotestronpropionate 17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one propionate 17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-onepropionate 17-beta-hydroxy-2-alpha-methyl-5-alpha-androstan-3-onpropionate 2alpha-Methyl-4,5-dihydrotestosterone propionate 2alpha-Methyldihydrotestosterone propionate 2a-methyl-5a-androstane-17b-ol-3-onepropionate 2a-methyl-dihydro-testosteronepropionate 2M-DHTP 2MDTP 2-methyl-17-(1-oxopropoxy)-androstan-3-on nsc-1298 Permastril Re 346 RS 1567 rs1567 Testosterone, 4,5alpha-dihydro-2alpha-methyl-, propionate Drostanolone Propionate (Masteron) 17b-hydroxy-2a-methyl-5a-androstan-3-one propionate DROSTANOLONE PROPIONATE DROMOSTANOLONE 17-PROPIONATE DROMOSTANOLONE PROPIONATE DrostanolonePropionate/Enanthate DrostanoloneProprionate Steroids Drostanolone Propionate Powder