WS 12
- CAS No.
- 68489-09-8
- Chemical Name:
- WS 12
- Synonyms
- WS 12;AR-15512;Cooler-12;Cooling agent WS12;Cooler than menthol;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide;N- (4- methoxy phenyl) - menthol -3- carboxylase;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12);(2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide;Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)-
- CBNumber:
- CB02455758
- Molecular Formula:
- C18H27NO2
- Molecular Weight:
- 289.41
- MDL Number:
- MFCD11100191
- MOL File:
- 68489-09-8.mol
- MSDS File:
- SDS
Boiling point | 447.8±28.0 °C(Predicted) |
---|---|
Density | 1.029±0.06 g/cm3(Predicted) |
vapor pressure | 0-0Pa at 20-50℃ |
FEMA | 4681 | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE |
storage temp. | -20°C |
solubility | DMSO: >20mg/mL |
pka | 14.18±0.70(Predicted) |
form | White to off-white powder. |
color | white to off-white |
Odor | at 100.00 %. cool minty |
Odor Type | minty |
JECFA Number | 2079 |
InChIKey | HNSGVPAAXJJOPQ-XOKHGSTOSA-N |
LogP | 3.95 at 22℃ and pH7.7 |
Substances Added to Food (formerly EAFUS) | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE |
CAS DataBase Reference | 68489-09-8 |
FDA UNII | 1L7BVT4Z4Z |
WS 12 price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | W0519 | WS-12 ≥98% (HPLC), powder | 68489-09-8 | 5mg | $190 | 2024-03-01 | Buy |
Tocris | 3040 | WS12 ≥99%(HPLC) | 68489-09-8 | 50 | $590 | 2021-12-16 | Buy |
Tocris | 3040 | WS12 ≥99%(HPLC) | 68489-09-8 | 10 | $141 | 2021-12-16 | Buy |
TRC | W500040 | WS12 | 68489-09-8 | 10mg | $105 | 2021-12-16 | Buy |
TRC | W500040 | WS12 | 68489-09-8 | 25mg | $210 | 2021-12-16 | Buy |
WS 12 Chemical Properties,Uses,Production
Description
WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.
Chemical Properties
WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors.
Uses
WS 12 is a potent TRPM8 agonist.
Trade name
Winsense WS-12 (Renessenz)
Biological Activity
Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).
Biochem/physiol Actions
WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.
storage
Store at -20°C
WS 12 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3878 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 2998 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 874 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9308 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23555 | 58 |
Zhuoer Chemical Co., Ltd | 02120970332; +8613524231522 | sales@zhuoerchem.com | China | 2905 | 58 |
View Lastest Price from WS 12 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-07-18 | WS 12
68489-09-8
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
2024-05-10 | Cooling agent WS-12
68489-09-8
|
US $18.00-18.00 / kg | 1kg | 99.9 | 5000 | Hebei Shengyang Water Conservancy Engineering Co., Ltd. | ||
2024-04-25 | Cooling agent WS-12
68489-09-8
|
US $25.00 / kg | 1kg | 99% | 5000kg/week | Hebei Zhuanglai Chemical Trading Co.,Ltd |
- WS 12
68489-09-8
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
- Cooling agent WS-12
68489-09-8
- US $18.00-18.00 / kg
- 99.9
- Hebei Shengyang Water Conservancy Engineering Co., Ltd.
- Cooling agent WS-12
68489-09-8
- US $25.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd