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OKADAIC ACID

OKADAIC ACID
OKADAIC ACID structure
CAS No.
78111-17-8
Chemical Name:
OKADAIC ACID
Synonyms
OA;NSC 677083;Okadic acid;OKADAIC ACID;Ocadaic Acid;HALOCHONDRINE A;Okadaic acid,97%;35-Demethyl-DTX 1;OKADAIC ACID, 98+%;OKADAIC ACID, 25 UG*
CBNumber:
CB0246204
Molecular Formula:
C44H68O13
Formula Weight:
805
MOL File:
78111-17-8.mol

OKADAIC ACID Properties

Melting point:
164-166 °C
alpha 
D20 +21° (c = 0.33 in CHCl3); D25 +25.4° (c = 0.24 in CHCl3)
Boiling point:
672.95°C (rough estimate)
Density 
1.0795 (rough estimate)
refractive index 
1.5940 (estimate)
storage temp. 
−20°C
solubility 
DMSO: ≥1 mg/mL
form 
translucent film
color 
translucent
Water Solubility 
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.
Merck 
13,6891
Stability:
Stable. Light and heat-sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
78111-17-8
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  23/24/25-38
Safety Statements  26-36/37-45
RIDADR  UN 3462 6.1/PG 1
WGK Germany  3
RTECS  AA8227800
10
HazardClass  6.1(a)
PackingGroup  II
HS Code  29321900
Toxicity LD50 i.p. in mice: 192 mg/kg (Shibata)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

OKADAIC ACID price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 495604 Okadaic acid 78111-17-8 25ug $86 2018-11-20 Buy
Sigma-Aldrich 495604 Okadaic acid 78111-17-8 100ug $304 2018-11-20 Buy
Alfa Aesar J60155 Okadaic acid, 98% 78111-17-8 100microg $170 2018-11-13 Buy
Alfa Aesar J60155 Okadaic acid, 98% 78111-17-8 50microgram $96 2018-11-13 Buy
Cayman Chemical 10011490 Okadaic Acid ≥95% 78111-17-8 25μg $39 2018-11-19 Buy

OKADAIC ACID Chemical Properties,Uses,Production

Chemical Properties

white crystals or powder

Uses

Okadaic acid is a widely distributed marine toxin produced by several phytoplanktonic species and responsible for diarrheic shellfish poisoning in humans. At the molecular level, Okadaic acid is a pot ent and specific inhibitor of various types of serine/threonine protein phosphatases. Due to this enzymatic inhibition, Okadaic acid was reported to induce numerous alterations in relevant cellular ph ysiological processes, including metabolic pathways such as glucose uptake, lipolysis and glycolysis, heme metabolism and glycogen and protein synthesis.

Uses

Biochemical tool as tumor promoter and probe of cellular regulation.

Biological Activity

Potent inhibitor of protein phosphatase 1 (IC 50 = 3 nM) and protein phosphatase 2A (IC 50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promotor. Shown to activate atypical protein kinase C in adipocytes.

OKADAIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products


OKADAIC ACID Suppliers

Global( 63)Suppliers
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J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
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