DDHL
- CAS No.
- 137173-46-7
- Chemical Name:
- DDHL
- Synonyms
- DDHL;C12-HSL;abs47045015;C12-HOMOSERINE LACTONE;N-Lauroyl-L-homoserine lactone;Dodecanoyl-L-hoMoserine lactone;N-DODECANOYL-L-HOMOSERINE LACTONE;N-[(3S)-2-oxooxolan-3-yl]dodecanamide;(S)-N-(2-Oxotetrahydrofuran-3-yl)dodecanamide;N-[(3S)-Tetrahydro-2-oxo-3-furanyl]dodecanamide
- CBNumber:
- CB02468631
- Molecular Formula:
- C16H29NO3
- Molecular Weight:
- 283.41
- MDL Number:
- MFCD11976890
- MOL File:
- 137173-46-7.mol
- MSDS File:
- SDS
| Melting point | 128 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| Boiling point | 485.8±34.0 °C(Predicted) |
| Density | 1.00±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform: 10 mg/ml; DMF: 1 mg/ml; DMSO: 1 mg/ml |
| form | A crystalline solid |
| pka | 14.71±0.20(Predicted) |
| optical activity | [α]/D -25±5°, c = 0.2 in methanol |
| BRN | 9281984 |
DDHL price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 68224 | N-Dodecanoyl-L-homoserine lactone ≥96% (HPLC) | 137173-46-7 | 10mg | $227 | 2024-03-01 | Buy |
| Sigma-Aldrich | 68224 | N-Dodecanoyl-L-homoserine lactone ≥98%, powder | 137173-46-7 | 50mg | $498 | 2024-03-01 | Buy |
| Cayman Chemical | 10011203 | N-dodecanoyl-L-Homoserine lactone ≥98% | 137173-46-7 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 10011203 | N-dodecanoyl-L-Homoserine lactone ≥98% | 137173-46-7 | 10mg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 10011203 | N-dodecanoyl-L-Homoserine lactone ≥98% | 137173-46-7 | 25mg | $193 | 2024-03-01 | Buy |
DDHL Chemical Properties,Uses,Production
Uses
Dodecanoyl-L-homoserine lactone is a modulator of cell communication and regulation.
Uses
Dodecanoyl-L-homoserine lactone is an active quorum sensing modulator first recognised in Sinorhizobium meliloti. N-Acylhomoserine lactones have been detected in hundreds of bacterial species and, while the homologues vary between species and strains, the homoserine lactones are the major chemical modulators of within and between cell communication and regulation. The most significant variable defining the function of the homoserine lactone is the length of the acyl chain, with shorter chains displaying opposing actions to the longer chains.
Uses
Dodecanoyl-L-homoserine lactone was confirmed to be an active quorum sensing modulator first recognised in Sinorhizobium meliloti. N-Acylhomoserine lactones have been detected in hundreds of bacterial species and, while the homologues vary between species and strains, the homoserine lactones are the major chemical modulators of within and between cell communication and regulation. The most significant variable defining the function of the homoserine lactone is the length of the acyl chain, with shorter chains displaying opposing actions to the longer chains.
Definition
ChEBI: An N-acyl-L-homoserine lactone having dodecanoyl as the acyl substituent.
Biochem/physiol Actions
N-Dodecanoyl-L-homoserine lactone is a member of N-acyl-homoserine lactone family. N-Acylhomoserine lactones (AHL) regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella, and are involved in quorum sensing, cell to cell communication among bacteria; for reviews see. Bacterial intercellular communication has become a target for the development of new anti-virulence drugs, and a research focus for the prevention of biofilm formation.
DDHL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 16621234537 | zhangsn@titansci.com | China | 14113 | 59 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3115 | 55 |
| Shanghai Leto Pharmatech Co.,Ltd. | 18016401466 | sales@letopharm.com | China | 219 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15878 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4459 | 55 |