ChemicalBook >> CAS DataBase List >>tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
![tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Structure](CAS2/GIF/1181816-12-5.gif)
- CAS No.
- 1181816-12-5
- Chemical Name:
- tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
- Synonyms
- tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate;2-Boc-6-oxo-2-azaspiro[3....;6-oxo-2-azaspiro[3.3]hept...;2-Boc-6-oxo-2-azaspiro[3.3]heptane;6-oxo-2-azaspiro[3.3]heptane-2-carboxyL;tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca;ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate;Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate;tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate;tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
- CBNumber:
- CB02470890
- Molecular Formula:
- C11H17NO3
- Molecular Weight:
- 211.26
- MDL Number:
- MFCD15071430
- MOL File:
- 1181816-12-5.mol
- MSDS File:
- SDS
Last updated:2023-04-27 16:27:43
| Melting point | 114.5-116 °C |
|---|---|
| Boiling point | 314.7±42.0 °C(Predicted) |
| Density | 1.16±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -0.93±0.20(Predicted) |
| form | solid |
| color | Pale yellow |
| InChI | InChI=1S/C11H17NO3/c1-10(2,3)15-9(14)12-6-11(7-12)4-8(13)5-11/h4-7H2,1-3H3 |
| InChIKey | HQHRAGXKFOTSQE-UHFFFAOYSA-N |
| SMILES | C1C2(CC(=O)C2)CN1C(OC(C)(C)C)=O |
| CAS DataBase Reference | 1181816-12-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312-P304+P340 |
| HS Code | 2933998090 |
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B809410 | tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate | 1181816-12-5 | 100mg | $60 | 2021-12-16 | Buy |
| TRC | B809410 | tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate | 1181816-12-5 | 500mg | $165 | 2021-12-16 | Buy |
| TRC | B809410 | tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate | 1181816-12-5 | 2.5g | $605 | 2021-12-16 | Buy |
| Apolloscientific | OR308105 | tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate | 1181816-12-5 | 1g | $141 | 2021-12-16 | Buy |
| Matrix Scientific | 070594 | 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylicacid tert-butyl ester 95% | 1181816-12-5 | 250mg | $457 | 2021-12-16 | Buy |
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Chemical Properties,Uses,Production
Uses
tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate is a reagent used for the preparation of γ-butyrolactone derivative via Baeyer-Villiger monooxygenase (BVMO)-catalyzed oxidation.
Synthesis
A solution of crude tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (1.00 g,4.69mmol, 1.00 equiv) in dichloromethane(20 mL) was treated with Dess-Martin periodinane(2.10g,4.95 mmol, 1.06 equiv) in two batches a few min apart at 0 °C. After 10 min, the ice bath wasremoved, and the reaction was monitored by TLC (50% ethyl acetate, PMA stain). After 30 min.the reaction was diluted with ethyl acetate and washed twice with satd sodium bicarbonate. Theorganic layer was dried over sodium sulfate, filtered, and concentrated. The crude product waspurified by flash chromatography (80g silica gel, 10 to 50% ethyl acetate/heptane; pure fractionswere identified by TLC with PMA stain; an unidentified impurity elutes slightly earlier than theproduct) to give tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate as a white solid (721 mg,73%). mp 114.5-116C.
Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate from tert-butyl 5,5-dichloro-6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 189)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BTC Nantong Pharmaceuticals Technology Co.,Ltd | +8618068193575 | sales4@btcpharm.com | China | 254 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9346 | 55 |
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| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7019 | 58 |
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| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![Tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate pictures](/ProductImageEN/2022-09/Small/208c6bfe-5db6-4764-97e3-a36c2c486b65.png) |
2024-03-28 | Tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
1181816-12-5
|
US $0.00 / KG | 25KG | 95% | Inquiry | PNP Biotech Co. Ltd | |
![Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate pictures](/ProductImageEN/2022-08/Small/56264ef2-1141-4a9f-822f-19fae402a699.png) |
2024-02-26 | Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate
1181816-12-5
|
US $0.00-0.00 / kg | 1kg | 99% | Kgs | BTC Nantong Pharmaceuticals Technology Co.,Ltd | |
![tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate pictures](/ProductImageEN/2022-08/Small/cb719b99-75c9-46b4-bc40-4f14ba264d38.png) |
2023-04-12 | tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
1181816-12-5
|
US $15.00 / Kg/Bag | 1Kg/Bag | 98% | 5000tons/year | Wuhan Dujiang Industrial Co., Ltd. |
-
- Tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
1181816-12-5
- US $0.00 / KG
- 95%
- PNP Biotech Co. Ltd
-
- Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate
1181816-12-5
- US $0.00-0.00 / kg
- 99%
- BTC Nantong Pharmaceuticals Technology Co.,Ltd
-
- tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
1181816-12-5
- US $15.00 / Kg/Bag
- 98%
- Wuhan Dujiang Industrial Co., Ltd.
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1181816-12-5
1363382-39-1 oldold
MFCD22421762 oldold