2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
- CAS No.
- 145100-51-2
- Chemical Name:
- 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
- Synonyms
- Comins;N-(5-CHLORO-2-PYRIDYL)TRIFLIMIDE;N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-;N-(5-CHLORO-2-PYRIDYL)BIS(TRIFLUOROMETHANESULFONIMIDE);N,N-BIS(TRIFLUOROMETHYLSULFONYL)-5-CHLORO-2-PYRIDYLAMINE;2-[N,N-BIS(TRIFLUOROMETHYLSULPHONYL)AMINO]-5-CHLOROPYRIDINE;N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide;Comins'reagent;Comins Triflating Reagent;N-(5-Chloropyridin-2-yl)triflimide
- CBNumber:
- CB0248253
- Molecular Formula:
- C7H3ClF6N2O4S2
- Molecular Weight:
- 392.68
- MDL Number:
- MFCD00191833
- MOL File:
- 145100-51-2.mol
- MSDS File:
- SDS
Melting point | 45-47 °C(lit.) |
---|---|
Boiling point | 77-90°C/0.2mmHg |
Density | 1.892±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Benzene (Slightly) |
form | Solid |
pka | -7.71±0.10(Predicted) |
color | yellow |
Water Solubility | Reacts with water. |
Sensitive | Moisture Sensitive |
BRN | 5833971 |
Stability | Moisture Sensitive, Unstable in DMSO Solution |
InChIKey | TUFGVZMNGTYAQD-UHFFFAOYSA-N |
CAS DataBase Reference | 145100-51-2(CAS DataBase Reference) |
FDA UNII | WS933U9U66 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
F | 9 | |||||||||
Hazard Note | Irritant | |||||||||
HazardClass | AIR SENSITIVE, IRRITANT-HARMFUL, KEEP COLD | |||||||||
HS Code | 29350090 | |||||||||
NFPA 704 |
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2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE price More Price(50)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 403644 | N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide) 96% | 145100-51-2 | 1g | $28.7 | 2024-03-01 | Buy |
Sigma-Aldrich | 403644 | N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide) 96% | 145100-51-2 | 5g | $127 | 2024-03-01 | Buy |
TCI Chemical | B1865 | 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent] >96.0%(GC) | 145100-51-2 | 5g | $83 | 2024-03-01 | Buy |
TCI Chemical | B1865 | 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent] >96.0%(GC) | 145100-51-2 | 25g | $412 | 2024-03-01 | Buy |
Alfa Aesar | L16929 | 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine, 99% | 145100-51-2 | 1g | $37.65 | 2024-03-01 | Buy |
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Chemical Properties,Uses,Production
Chemical Properties
White to pale yellow crystalline solid
Uses
Reactant for:
Suzuki-Miyaura cross coupling
Synthesis of nicotinic acetylcholine receptor-selective ligands
Enantioselective desymmetrizing palladium catalyzed carbonylation reactions
Synthesis of high affinity niacin receptor GPR109A agonists
Preparation of heteroaromatics
Uses
2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates. It is used in the total synthesis of (-)-porantheridine and the trans decahydroquinoline alkaloid (+)-219A. It is also used as a reactant for Suzuki-Miyaura cross coupling, synthesis of nicotinic acetylcholine receptor-selective ligands, enantioselective desymmetrizing palladium catalyzed carbonylation reactions, synthesis of high affinity niacin receptor GPR109A agonists and in preparation of heteroaromatics.
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
View Lastest Price from 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-01-02 | 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
145100-51-2
|
US $50.00-500.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | ||
2023-08-18 | 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
145100-51-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2022-11-04 | 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
145100-51-2
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Guanlang Biotechnology Co., Ltd. |
- 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
145100-51-2
- US $50.00-500.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
- 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
145100-51-2
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
145100-51-2
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.