VU0155041 sodium salt
- CAS No.
- 1259372-69-4
- Chemical Name:
- VU0155041 sodium salt
- Synonyms
- VU0155041 sodium;VU0155041 sodium salt;VU-0155041 sodium,VU0155041 sodium;cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylicacidsodiumsalt
- CBNumber:
- CB02487584
- Molecular Formula:
- C14H14Cl2NNaO3
- Molecular Weight:
- 338.162
- MDL Number:
- MOL File:
- 1259372-69-4.mol
VU0155041 sodium salt price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21775 | VU0155041 (sodium salt) ≥98% | 1259372-69-4 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21775 | VU0155041 (sodium salt) ≥98% | 1259372-69-4 | 10mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 21775 | VU0155041 (sodium salt) ≥98% | 1259372-69-4 | 50mg | $169 | 2024-03-01 | Buy |
| Tocris | 3311 | VU0155041sodiumsalt ≥98%(HPLC) | 1259372-69-4 | 50 | $273 | 2021-12-16 | Buy |
| Tocris | 3311 | VU0155041sodiumsalt ≥98%(HPLC) | 1259372-69-4 | 10 | $74 | 2021-12-16 | Buy |
VU0155041 sodium salt Chemical Properties,Uses,Production
Description
VU0155041 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with an EC50 value of 2.5 μM for glutamate response in a thallium flux assay. It is selective for mGluR4, exhibiting no effect on radioligand binding at 67 G protein-coupled receptors, ion channels, and transporters, and lacking antagonist activity at NMDA receptors in striatal medium spiny neurons at a concentration of 10 μM. In vivo, VU0155041 decreases catalepsy induced by haloperidol and reverses askinesias induced by reserpine in rat models of Parkinson’s disease. Chronic treatment with VU0155041 restores social behavior in the Oprm-/- mouse model of autism. It also increases the percentage of time spent in the open arms of the elevated plus maze, a measure of decreased anxiety, in mice.
Uses
VU 0155041 Sodium Salt is a positive allosteric modulator of group III mGlu4 receptor that provides functional neuprotection in 6-hydroxydopamine rat models with parkinson’s disease.
VU0155041 sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
VU0155041 sodium salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 18779 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8732 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |