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BIX 02188

CAS No.
1094614-84-2
Chemical Name:
BIX 02188
Synonyms
CS-38;BIX 02188;(E/Z)-BIX02188;BIX 02188, >=98%;BIX 02188 USP/EP/BP;BIX 02188(BIX-02188;BIX 02188(BIX-02188;BIX02188);BIX-02188(Random Configuration);BIX-02188 BIX02188MEK5 inhibitor potent and selective;3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
CBNumber:
CB02489917
Molecular Formula:
C25H24N4O2
Molecular Weight:
412.48366
MDL Number:
MFCD18157583
MOL File:
1094614-84-2.mol
Last updated:2023-04-23 13:52:06

BIX 02188 Properties

Melting point >268oC (dec.)
Boiling point 615.8±55.0 °C(Predicted)
Density 1.283
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 11.19±0.20(Predicted)
color Yellow
FDA UNII 4Y3VYY2X83

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933998090

BIX 02188 price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B591685 BIX02188 1094614-84-2 10mg $150 2021-12-16 Buy
Usbiological 162918 BIX02188 1094614-84-2 10mg $460 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000917 3-[[[3-[(DIMETHYLAMINO)METHYL]PHENYL]AMINO]PHENYLMETHYLENE]-2,3-DIHYDRO-2-OXO-1H-INDOLE-6-CARBOXAMIDE 95.00% 1094614-84-2 5MG $496.31 2021-12-16 Buy
Biorbyt Ltd orb154720 BIX02188 (BIX 02188) >98% 1094614-84-2 100mg $765 2021-12-16 Buy
AK Scientific X7394 (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide 1094614-84-2 50mg $876 2021-12-16 Buy
Product number Packaging Price Buy
B591685 10mg $150 Buy
162918 10mg $460 Buy
KIN0000917 5MG $496.31 Buy
orb154720 100mg $765 Buy
X7394 50mg $876 Buy

BIX 02188 Chemical Properties,Uses,Production

Uses

BIX02188 MEK inhibitor, prevents cell proliferation and induces apoptosis. Can be applied towards treatments of cancers and proliferative cell diseases.

Biological Activity

bix 02188 is a selective inhibitor of mek5 with ic50 value of 4.3 nm 1.bix 02188 belongs to the indolinone kinase inhibitor series. it selectively inhibited the catalytic activity of mek5 but not other closely related kinases such as mek1, mek2, erk2 and jnk2. bix 02188 also inhibited erk5 with ic50 value of 810 nm. in hela cells, treatment of bix 02188 inhibited the phosphorylation of erk5 but not erk1/2. besides that, bix 02188 prevented the transcription of the downstream substrate mef2c in hela and hek293 cells. when tested with a panel of 79 kinases, bix 02188 showed some degree of inhibition of the kinases csf1r, kit and lck with ic50 values of 280 nm, 550 nm and 390 nm, respectively 1.

target

MEK5

References

1. tatake r j, o’neill m m, kennedy c a, et al. identification of pharmacological inhibitors of the mek5/erk5 pathway. biochemical and biophysical research communications, 2008, 377(1): 120-125.

BIX 02188 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 102)Suppliers
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Capot Chemical Co.,Ltd.
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TargetMol Chemicals Inc.
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BIX 02188 Spectrum

1094614-84-2(BIX 02188)Related Search:

3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide BIX 02188 BIX 02188(BIX-02188 BIX 02188(BIX-02188;BIX02188) (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide 3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide BIX 02188 BIX 02188, >=98% BIX 02188 USP/EP/BP 3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide CS-38 BIX-02188(Random Configuration) (E/Z)-BIX02188 BIX-02188 BIX02188MEK5 inhibitor potent and selective 1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo- 1094614-84-2 Inhibitors MAPK