Foretinib (GSK1363089)
- CAS No.
- 849217-64-7
- Chemical Name:
- Foretinib (GSK1363089)
- Synonyms
- Foretinib;XL880;EXEL-2880;GSK089;GSK 1363089;XL-880,Foretinib;EXEL-2880/XL-880;Foretinib, >=98%;XL880(GSK1363089);Foretinib (XL-880)
- CBNumber:
- CB02490083
- Molecular Formula:
- C34H34F2N4O6
- Molecular Weight:
- 632.65
- MDL Number:
- MFCD22379992
- MOL File:
- 849217-64-7.mol
- MSDS File:
- SDS
| Melting point | >98°C (dec.) |
|---|---|
| Boiling point | 828.5±65.0 °C(Predicted) |
| Density | 1.372 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Ethanol (Slightly) |
| form | Yellow powder. |
| pka | 13.14±0.70(Predicted) |
| color | Pale Yellow to Yellow |
| CAS DataBase Reference | 849217-64-7 |
| NCI Dictionary of Cancer Terms | foretinib; XL880 |
| FDA UNII | 81FH7VK1C4 |
| NCI Drug Dictionary | foretinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H373-H302 | |||||||||
| Precautionary statements | P260-P314-P501-P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Foretinib (GSK1363089) price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16249 | Foretinib ≥98% | 849217-64-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16249 | Foretinib ≥98% | 849217-64-7 | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 16249 | Foretinib ≥98% | 849217-64-7 | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16249 | Foretinib ≥98% | 849217-64-7 | 25mg | $230 | 2024-03-01 | Buy |
| Tocris | 6056 | GSK1363089 ≥98%(HPLC) | 849217-64-7 | 10 | $177 | 2021-12-16 | Buy |
Foretinib (GSK1363089) Chemical Properties,Uses,Production
Description
Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
Description
Foretinib is a multikinase inhibitor that targets MET and VEGFR2 and also exhibits an inhibitory effect against KIT, Flt-3, PDGFRb, and Tie-2.
Uses
XL880 (GSK1363089, EXEL-2880) is an ATP-competitive inhibitor of MET and KDR with IC50 of 0.4 nM and 0.9 nM, respectively.
Uses
Foretinib (GSK1363089) is an ATP-competitive inhibitor of hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF) Receptor Tyrosine Kinases.
Definition
ChEBI: N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide is an aromatic ether.
Clinical Use
Foretinib has also shown to be effective against ROS1 mutations especially when acquired with crizotinib resistance. A clinical trial investigating the dosing and safety profile of combining foretinib and erlotinib was designed for advanced pretreated NSCLC patients.
in vitro
In vitro, foretinib blocks activation of MET and VEGFR2-induced signaling pathways. In vivo experiments show a dose-dependent decrease in tumor burden in a lung metastasis experimental model.
target
Met
References
[1] qian f1, engst s, yamaguchi k, yu p, won ka, mock l, lou t, tan j, li c, tam d, lougheed j, yakes fm, bentzien f, xu w, zaks t, wooster r,greshock j, joly ah. inhibition of tumor cell growth, invasion, and metastasis by exel-2880 (xl880, gsk1363089), a novel inhibitor of hgf and vegf receptor tyrosine kinases. cancer res. 2009 oct 15;69(20):8009-16. doi: 10.1158/0008-5472.can-08-4889.
Foretinib (GSK1363089) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from Foretinib (GSK1363089) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-10-14 | Foretinib (GSK1363089)
849217-64-7
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | Foretinib (GSK1363089)
849217-64-7
|
US $2.00 / kg | 1 kg | 99% | 100kg | Career Henan Chemical Co |
-
- Foretinib (GSK1363089)
849217-64-7
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Foretinib (GSK1363089)
849217-64-7
- US $2.00 / kg
- 99%
- Career Henan Chemical Co