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Ramipril

Description References
Ramipril
Ramipril structure
CAS No.
87333-19-5
Chemical Name:
Ramipril
Synonyms
DELIX;RAMACE;ALTACE;Trimce;vesdil;PRAMACE;TRITACE;UNIPRIL;CARDACE;HOE-498
CBNumber:
CB0249104
Molecular Formula:
C23H32N2O5
Formula Weight:
416.51
MOL File:
87333-19-5.mol

Ramipril Properties

Melting point:
106-108°C
Boiling point:
616.2±55.0 °C(Predicted)
alpha 
D24 +33.2° (c = 1 in 0.1N ethanolic HCl)
Density 
1.200±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ~18mg/mL
pka
pKa 3.30±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain);5.75±0.00(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain)
form 
powder
color 
white
CAS DataBase Reference
87333-19-5(CAS DataBase Reference)
FDA UNII
L35JN3I7SJ
NCI Drug Dictionary
Altace
ATC code
C09AA05
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-37/39
WGK Germany  2
RTECS  GY5879600
HS Code  2933995300
Toxicity LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer)

Ramipril price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1446 Ramipril Pharmaceutical Secondary Standard; Certified Reference Material 87333-19-5 1g $85.4 2021-03-22 Buy
Sigma-Aldrich R0145000 Ramipril European Pharmacopoeia (EP) Reference Standard 87333-19-5 $190 2021-03-22 Buy
Sigma-Aldrich BP751 Ramipril British Pharmacopoeia (BP) Reference Standard 87333-19-5 $190 2021-03-22 Buy
Sigma-Aldrich 1598303 Ramipril United States Pharmacopeia (USP) Reference Standard 87333-19-5 125mg $366 2021-03-22 Buy
TCI Chemical R0219 Ramipril 87333-19-5 5G $360 2021-03-22 Buy

Ramipril Chemical Properties,Uses,Production

Description

Ramipril (brand name: Altace) is a kind of prodrug which is capable of inhibiting the angiotensin-converting enzyme (ACE) which converting angiotensin I to angiotensin II. It is metabolized to ramiprilat in the liver which exerts the effect of ACE inhibition. It is used for the treatment of hypertension, congestive heart failure and nephropathy. It can also be used for the prevention of heart attack, stroke and cardiovascular death. It can also be used for the treatment of kidney damage due to diabetes with protein-containing urine. Ramiprilat, is the competitive inhibitor of ATI for binding to ACE, further inhibiting the enzymatic proteolysis of ATI to ATII, alleviating the effect of ATII on blood pressure.

References

https://en.wikipedia.org/wiki/Ramipril
https://www.drugbank.ca/drugs/DB00178

Description

Ramipril, a prodrug of ramiprilat, is a long-acting, tissue-specific and non-sulfhydryl ACE inhibitor useful in the treatment of mild to moderate hypertension. In animal studies ramipril exerted cardioprotective effects resembling those of bradykinin in cardiac reperfusion injuries. Ramipril is also reportedly useful in congestive heart failure.

Chemical Properties

White Solid

Originator

Hoechst AG (W. Germany)

Uses

cardiotonic

Uses

An inhibitor of the angiotensin- coverting enzyme (ACE)

Uses

Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]

Uses

An antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite

Definition

ChEBI: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.

brand name

Altace (King);Triatec.

General Description

Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), ishydrolyzed to ramiprilat, its active diacid form, faster thanenalapril is hydrolyzed to its active diacid form. Peak serumconcentrations from a single oral dose are achieved between1.5 and 3 hours. The ramiprilate formed completely suppresses ACE activity for up to 12 hours, with 80% inhibitionof the enzyme still observed after 24 hours.

Veterinary Drugs and Treatments

Ramipril is a long-acting angiotensin converting enzyme (ACE) inhibitor that may be useful in treating heart failure or hypertension in dogs or cats. It is an approved product in the UK for treating heart failure in dogs. In cats, ramipril has been used for treating arterial hypertension. A recent study (MacDonald, Kittleson et al. 2006) did not show any significant benefit using ramipril in treating Maine Coon cats with hypertrophic cardiomyopathy without heart failure.
Like other ACE inhibitors, it may potentially be useful as adjunctive treatment in chronic renal failure and protein losing nephropathies. In dogs with moderate renal impairment (such as might be found with CHF), there is apparently no need to adjust ramipril dosage.

Ramipril Preparation Products And Raw materials

Raw materials

Preparation Products


Ramipril Suppliers

Global( 349)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20898 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58

View Lastest Price from Ramipril manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-07 Ramipril
87333-19-5
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-01 Ramipril
87333-19-5
US $1.90 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2021-11-20 Ramipril
87333-19-5
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd

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