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TW-37

CAS No.
877877-35-5
Chemical Name:
TW-37
Synonyms
TW-37;CS-299;TW37;TW 37;TW-37 USP/EP/BP;TW-37/Bcl-2Inhibitor;inhibit,Bcl-2 Family,TW37,TW-37,Inhibitor;5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide;N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide;TW-37/N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide;N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide
CBNumber:
CB02500999
Molecular Formula:
C33H35NO6S
Molecular Weight:
573.7
MDL Number:
MFCD17010275
MOL File:
877877-35-5.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00

TW-37 Properties

Boiling point 723.7±60.0 °C(Predicted)
Density 1.280
storage temp. Store at -20°C
solubility insoluble in H2O; ≥19.75 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with gentle warming and ultrasonic
form A crystalline solid
pka 7.86±0.50(Predicted)
FDA UNII FQ8NY4LUO5

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

TW-37 price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20999 TW-37 ≥98% 877877-35-5 5mg $110 2024-03-01 Buy
Cayman Chemical 20999 TW-37 ≥98% 877877-35-5 10mg $185 2024-03-01 Buy
Cayman Chemical 20999 TW-37 ≥98% 877877-35-5 25mg $380 2024-03-01 Buy
Cayman Chemical 20999 TW-37 ≥98% 877877-35-5 50mg $648 2024-03-01 Buy
Tocris 4038 TW37 ≥97%(HPLC) 877877-35-5 50 $835 2021-12-16 Buy
Product number Packaging Price Buy
20999 5mg $110 Buy
20999 10mg $185 Buy
20999 25mg $380 Buy
20999 50mg $648 Buy
4038 50 $835 Buy

TW-37 Chemical Properties,Uses,Production

Description

TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively). It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells. TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously. It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.

Uses

TW-37 is a Bcl-2 inhibitor that suppresses growth and enhance cisplatin-induced apoptosis in ovarian cancer cells. Also functions as an MCL-1 inhibitor that kills many more malignant cells.

Uses

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

Definition

ChEBI: N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide is a member of benzamides.

TW-37 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 101)Suppliers
Supplier Tel Email Country ProdList Advantage
Accela ChemBio Inc.
(+1)-858-699-3322 info@accelachem.com United States 19965 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9589 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
027-88013699 17354350817 Ryan@jiutian-bio.com China 7433 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58

View Lastest Price from TW-37 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TW-37 pictures 2020-01-09 TW-37
877877-35-5
US $0.01 / KG 500g 98%; 99% 500g;1kg; 10kg; 25kg Career Henan Chemical Co
  • TW-37 pictures
  • TW-37
    877877-35-5
  • US $0.01 / KG
  • 98%; 99%
  • Career Henan Chemical Co

TW-37 Spectrum

877877-35-5(TW-37)Related Search:

TW-37 N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide 5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide TW-37 Bcl-2 Inhibitor N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide CS-299 TW37;TW 37 Benzamide, N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]- N-{4-[(2-tert-butylbenzene)sulfonyl]phenyl}-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide TW-37 USP/EP/BP N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide inhibit,Bcl-2 Family,TW37,TW-37,Inhibitor TW-37/Bcl-2Inhibitor TW-37/N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 877877-35-5 33H35NO6S C33H35NO6S Inhibitor Inhibitors