LDN-193189 HCl
- CAS No.
- 1062368-62-0
- Chemical Name:
- LDN-193189 HCl
- Synonyms
- CS-1451;LDN-193189 HCl;LDN-193189 4HCl;LDN-193189 HCl USP/EP/BP;LDN193189 (Hydrochloride);LDN-193189 HCL;LDN 193189 HCL;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl;LDN193189 hydrochloride, 98%, a selective BMP type I receptor kinases inhibitor;LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride
- CBNumber:
- CB02517951
- Molecular Formula:
- C25H23ClN6
- Molecular Weight:
- 442.94332
- MDL Number:
- MFCD17392570
- MOL File:
- 1062368-62-0.mol
| Melting point | >240°C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Methanol (Slightly), DMSO (Very Slightly, Heated) |
| form | Solid |
| color | Dark Orange |
| CAS DataBase Reference | 1062368-62-0 |
| FDA UNII | PLH51K438W |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
LDN-193189 HCl price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) ≥98% | 1062368-62-0 | 1mg | $25 | 2021-12-16 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) ≥98% | 1062368-62-0 | 5mg | $75 | 2021-12-16 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) ≥98% | 1062368-62-0 | 10mg | $138 | 2021-12-16 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) ≥98% | 1062368-62-0 | 25mg | $300 | 2021-12-16 | Buy |
| TRC | P480133 | LDN193189 hydrochloride | 1062368-62-0 | 10mg | $195 | 2021-12-16 | Buy |
LDN-193189 HCl Chemical Properties,Uses,Production
Uses
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Hydrochoride is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases.
Uses
LDN-193189 HCl has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.
Biological Activity
ldn193189 is a selective transcriptional activity morphogenetic protein (bmp) type i receptors inhibitor. it inhibits activin receptor-like kinase-2 (alk2) and alk3 with ic50 values of 5 nm and 30 nm, respectively [1].ldn193189 has been showed to inhibit bmp induced phosphorylation of smad signaling (smad1/5/8) and non-smad signaling including p38 and akt in c2c12 cells [2].pharmacological inhibition of bmp by ldn193189 has shown to prevent down-regulation of e-cadherin in response to bmp2 both in bronchial epithelial (beas2b) cells and in c57bl/6 mice. ldn193189 also inhibits the bmp-induced reduction of epithelial permeability at cellular level [3].
References
[1] yu pb, deng dy, lai cs, hong cc, cuny gd, bouxsein ml, hong dw, mcmanus pm, katagiri t, sachidanandan c, kamiya n, fukuda t, mishina y, peterson rt, bloch kd. bmp type i receptor inhibition reduces heterotopic [corrected] ossification. nat med. 2008 dec;14(12):1363-9.
[2] boergermann jh1, kopf j, yu pb, knaus p. dorsomorphin and ldn-193189 inhibit bmp-mediated smad, p38 and akt signalling in c2c12 cells. int j biochem cell biol. 2010 nov;42(11):1802-7.
[3] helbing t1, herold em, hornstein a, wintrich s, heinke j, grundmann s, patterson c, bode c, moser m. inhibition of bmp activity protects epithelial barrier function in lung injury. j pathol. 2013 sep;231(1):105-16. doi: 10.1002/path.4215. epub 2013 jul 10.
LDN-193189 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from LDN-193189 HCl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | LDN-193189 HCl
1062368-62-0
|
US $1.00 / g | 1g | 99.99% | 200kg | Career Henan Chemical Co |
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- LDN-193189 HCl
1062368-62-0
- US $1.00 / g
- 99.99%
- Career Henan Chemical Co