4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
- CAS No.
- 15427-93-7
- Chemical Name:
- 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
- Synonyms
- DDUG diMS;NSC 109555;NSC109555 Dimesylate;NSC 109555 ditosylate;DDUG dimethanesulfonate;4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate;2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2)
- CBNumber:
- CB02518817
- Molecular Formula:
- C20H28N10O4S
- Molecular Weight:
- 504.56592
- MDL Number:
- MOL File:
- 15427-93-7.mol
- MSDS File:
- SDS
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0781 | NSC109555 ≥98% (HPLC) | 15427-93-7 | 5mg | $95.7 | 2022-05-15 | Buy |
| Sigma-Aldrich | SML0781 | NSC109555 ≥98% (HPLC) | 15427-93-7 | 25mg | $377 | 2022-05-15 | Buy |
| Cayman Chemical | 19811 | NSC 109555 | 15427-93-7 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 19811 | NSC 109555 | 15427-93-7 | 5mg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 19811 | NSC 109555 | 15427-93-7 | 10mg | $140 | 2024-03-01 | Buy |
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Chemical Properties,Uses,Production
Uses
NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death.
Uses
NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be b eneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caus ed acute paralysis leading to apnea and death.
Biochem/physiol Actions
NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM.
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Preparation Products And Raw materials
Raw materials
Preparation Products
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |