NBI 35965 hydrochloride
- CAS No.
- 603151-83-3
- Chemical Name:
- NBI 35965 hydrochloride
- Synonyms
- NBI-35965 Mesylate;NBI 35965 hydrochloride
- CBNumber:
- CB02535685
- Molecular Formula:
- C22H26Cl2N4O3S
- Molecular Weight:
- 497.43784
- MDL Number:
- MOL File:
- 603151-83-3.mol
- MSDS File:
- SDS
| Melting point | 167 °C |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO > 10 mM |
| form | Powder |
| FDA UNII | PY3M6M5BK4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
NBI 35965 hydrochloride price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18524 | NBI 35965 (mesylate) ≥95% | 603151-83-3 | 1 mg | $30 | 2024-03-01 | Buy |
| Cayman Chemical | 18524 | NBI 35965 (mesylate) ≥95% | 603151-83-3 | 5mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 18524 | NBI 35965 (mesylate) ≥95% | 603151-83-3 | 10mg | $148 | 2024-03-01 | Buy |
| Cayman Chemical | 18524 | NBI 35965 (mesylate) ≥95% | 603151-83-3 | 25mg | $333 | 2024-03-01 | Buy |
| Cayman Chemical | 18524 | NBI 35965 (mesylate) ≥95% | 603151-83-3 | 50mg | $723 | 2023-01-06 | Buy |
NBI 35965 hydrochloride Chemical Properties,Uses,Production
Uses
NBI 35965 Mesylate is a selective corticotropin-releasing factor (CRF1) receptor antagonist involved in stress response.
Uses
Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. NBI 35965 is a selective CRF receptor 1 (CRF1) antagonist with a Ki value of 4 nM. It does not inhibit CRF2 (Ki = >10,000 nM). NBI 35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo. In animal models of stress, NBI 35965 administration produces anxiolytic effects.[Cayman Chemical]
Uses
NBI 35965 Hydrochloride is a potent and selective corticotropin-releasing factor 1 (CRF1) antagonist.
NBI 35965 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
NBI 35965 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8017 | 62 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |