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N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide

N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide structure
CAS No.
918504-65-1
Chemical Name:
N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
Synonyms
R7204;104532;CS-1916;Vemurafenib, >=99%;PLX4032 (VeMurafenib);Zelboraf (vemurafenib);(1029872-54-5) vemurafenib;Vemurafenib (RG7204,PLX4032);VeMurafenib (PLX4032, RG7204);RG7204;PLX-4032;PLX 4032;RG-7204
CBNumber:
CB02550000
Molecular Formula:
C23H18ClF2N3O3S
Formula Weight:
489.9221264
MOL File:
918504-65-1.mol

N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Properties

Density 
1.46
form 
White powder.
pka
6.26±0.10(Predicted)
CAS DataBase Reference
918504-65-1
SAFETY
  • Risk and Safety Statements
HS Code  29339900

N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10618 PLX4032 ≥98% 918504-65-1 5mg $39 2020-06-24 Buy
Cayman Chemical 10618 PLX4032 ≥98% 918504-65-1 10mg $66 2020-06-24 Buy
Cayman Chemical 10618 PLX4032 ≥98% 918504-65-1 25mg $146 2020-06-24 Buy
Cayman Chemical 10618 PLX4032 ≥98% 918504-65-1 50mg $254 2020-06-24 Buy

N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Chemical Properties,Uses,Production

Description

In August 2011, the United States FDA approved vemurafenib (PLX- 4032, RO-5185426) for the treatment of patients with metastatic melanoma with the BRAFV600E mutation. Vemurafenib has been developed as a targeted therapy for patients with the BRAF gene mutation since oncogenic B-raf signaling is implicated in approximately 50% of melanomas. Vemurafenib was identified based on an initial high-throughput screen followed by the extensive use of structure-based drug design. Vemurafenib is a potent inhibitor of B-RafV600E kinase (IC50=13 nM) compared to its potency against wildtype B-raf (IC50=160 nM) and is fairly selective versus a panel of 200 kinases. It does inhibit other kinases (RAF1, SRMS, ACK1, MAP4K5, and FGR) and mutant B-raf kinases (BRAFV600K, BRAFV600D, and BRAFV600R) with enzyme IC50's of <100 nM.

Chemical Properties

Off-White Solid

Originator

Plexxikon (United States)

Uses

PLX4032 is an orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively). It inhibits cell proliferation in a variety of cell lines expressing B-Raf V600E and synergizes strongly with taxol, vinblastine, and oxaliplatin in inhibiting the proliferation of B-RafV600E transformed cancer cells. PLX4032 is effective against the growth of tumors bearing the B-Raf V600E mutation.[Cayman Chemical]

Uses

Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600.

Uses

Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM

Definition

ChEBI: A pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone ormal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases.

brand name

Zelboraf

N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Preparation Products And Raw materials

Raw materials

Preparation Products


N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Suppliers

Global( 197)Suppliers
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Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22623 55
ATK CHEMICAL COMPANY LIMITED
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Accela ChemBio Inc.
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BOC Sciences
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Chongqing Chemdad Co., Ltd
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View Lastest Price from N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-08-21 Vemurafenib
918504-65-1
US $1.00 / KG 1KG 99% 5000KG Shenzhen Excellent Biotech Co., Ltd.
2020-04-30 PLX4032 (Vemurafenib)
918504-65-1
US $0.00-0.00 / 公斤 1公斤 99.0% 800 ton Shaanxi Dideu Medichem Co. Ltd
2019-09-01 N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
918504-65-1
US $7.00 / KG 1KG 99% JD 484 career henan chemical co

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