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2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester

CAS No.
6274-50-6
Chemical Name:
2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester
Synonyms
Methyl 2-(4-Methoxyphenyl)-2-Methylpropanoate;2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester;Benzeneacetic acid, 4-methoxy-α,α-dimethyl-, methyl ester
CBNumber:
CB02550479
Molecular Formula:
C12H16O3
Molecular Weight:
208.25
MDL Number:
MFCD19441873
MOL File:
6274-50-6.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:51
Product description Number Pack Size Price
Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 98% AS42393 250mg $210
Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 98% AS42393 1g $412
Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 98% AS42393 5g $1282
Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 126898 1.00g $694
Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 126898 5.00g $2080

2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester Properties

storage temp. Sealed in dry,Room Temperature

2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS42393 Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 98% 6274-50-6 250mg $210 2026-06-04 Buy
Activate Scientific AS42393 Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 98% 6274-50-6 1g $412 2026-06-04 Buy
Activate Scientific AS42393 Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 98% 6274-50-6 5g $1282 2026-06-04 Buy
Matrix Scientific 126898 Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 6274-50-6 1.00g $694 2026-05-18 Buy
Matrix Scientific 126898 Methyl 2-(4-methoxyphenyl)-2-methylpropanoate 6274-50-6 5.00g $2080 2026-05-18 Buy
Product number Packaging Price Buy
AS42393 250mg $210 Buy
AS42393 1g $412 Buy
AS42393 5g $1282 Buy
126898 1.00g $694 Buy
126898 5.00g $2080 Buy

2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester Chemical Properties,Uses,Production

Synthesis

METHYL 4-METHOXYPHENYLACETATE

23786-14-3

Iodomethane

74-88-4

2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester

6274-50-6

Methyl iodomethane (23.64 g, 166.5 mmol) was added slowly and dropwise to a tetrahydrofuran (THF, 100 mL) solution of methyl 2-(4-methoxyphenyl)acetate (10.0 g, 55.49 mmol) at -78 °C. Subsequently, potassium tert-butoxide (KOt-Bu, 18.68 g, 166.5 mmol) was added in batches over 30 min, keeping the reaction mixture stirred at -78 °C for 1 h. The reaction was then brought to room temperature and continued to be stirred for 1 h. The reaction was completed by the addition of potassium tert-butoxide (KOt-Bu, 18.68 g, 166.5 mmol). Upon completion of the reaction, the reaction was quenched by the addition of water (25 mL) and extracted with ethyl acetate (EtOAc, 2 x 250 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give methyl 2-(4-methoxyphenyl)-2-methylpropionate (10.46 g, 91% yield).

References

[1] Patent: WO2013/19682, 2013, A1. Location in patent: Page/Page column 87
[2] Patent: WO2013/19635, 2013, A1. Location in patent: Page/Page column 55
[3] Helvetica Chimica Acta, 1971, vol. 54, p. 868 - 897
[4] Biomedical mass spectrometry, 1976, vol. 3, # 6, p. 316 - 328
[5] Patent: US5776951, 1998, A

2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester Preparation Products And Raw materials

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2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester Methyl 2-(4-Methoxyphenyl)-2-Methylpropanoate Benzeneacetic acid, 4-methoxy-α,α-dimethyl-, methyl ester 6274-50-6