(+)-Fluprostenol
- CAS No.
- 54276-17-4
- Chemical Name:
- (+)-Fluprostenol
- Synonyms
- (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid;AL 5848;Travoprost 2;Travoprost Acid;(+)-Fluprostenol;Travoprost Acid-d4;[3H]-Travoprost acid;Travoprost free acid;Ttravoprost free acid;Travoprost impurity E
- CBNumber:
- CB02551360
- Molecular Formula:
- C23H29F3O6
- Molecular Weight:
- 458.47
- MDL Number:
- MFCD00210955
- MOL File:
- 54276-17-4.mol
| Boiling point | 608.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.335±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated), Dichloromethane, Acetonitrile |
| form | Solid |
| pka | 4.76±0.10(Predicted) |
| color | Colourless to Pale Yellow Oil |
| FDA UNII | MEH3MCE8X1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H372-H370-H300+H310+H330 | |||||||||
| Precautionary statements | P260-P264-P270-P307+P311-P321-P405-P501-P260-P264-P270-P314-P501 | |||||||||
| HS Code | 2937500000 | |||||||||
| NFPA 704 |
|
(+)-Fluprostenol price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16768 | Fluprostenol ≥95% | 54276-17-4 | 1mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 16768 | Fluprostenol ≥95% | 54276-17-4 | 5mg | $280 | 2024-03-01 | Buy |
| Cayman Chemical | 16768 | Fluprostenol ≥95% | 54276-17-4 | 10mg | $497 | 2024-03-01 | Buy |
| Cayman Chemical | 16768 | Fluprostenol ≥95% | 54276-17-4 | 25mg | $1084 | 2024-03-01 | Buy |
| TRC | T715620 | TravoprostAcid | 54276-17-4 | 25mg | $895 | 2021-12-16 | Buy |
(+)-Fluprostenol Chemical Properties,Uses,Production
Uses
Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity. Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively. It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 μg/kg to terminate pregnancy. It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10?11 M.[Cayman Chemical]
Uses
A metabolically stable analog of Prostaglandin F2α (P838625) with potent FP receptor agonist activity. An impurity of Travoprost (T715600).
Definition
ChEBI: Fluprostenol is an organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea. It has a role as an antiglaucoma drug, an antihypertensive agent, a prostaglandin receptor agonist, a female contraceptive drug and an abortifacient. It is a prostaglandins Falpha, a hydroxy monocarboxylic acid and a member of (trifluoromethyl)benzenes.
(+)-Fluprostenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Scinova Biotech(Guangzhou) Co., Ltd. | 13268215580 | scinova_sales@163.com | China | 7026 | 58 |