SMIFH2
- CAS No.
- 340316-62-3
- Chemical Name:
- SMIFH2
- Synonyms
- SMIFH2;SMIFH2 >=98% (HPLC);SMIFH2 Formin FH2 Domain Inhibitor;Formin FH2 Domain Inhibitor, SMIFH2;5-Furylidene,1-(3-Bromophenyl)-2-Thiobarbituric Acid;Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem;1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione;1-(3-Bromophenyl)-5-(furan-2-ylmethylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;4,6(1H,5H)-Pyrimidinedione, 1-(3-bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-;(5E)-1-(3-bromophenyl)-5-(furan-2-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
- CBNumber:
- CB02565932
- Molecular Formula:
- C15H9BrN2O3S
- Molecular Weight:
- 377.21
- MDL Number:
- MOL File:
- 340316-62-3.mol
- MSDS File:
- SDS
SMIFH2 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S4826 | SMIFH2 ≥98% (HPLC) | 340316-62-3 | 5mg | $155 | 2024-03-01 | Buy |
| Sigma-Aldrich | 344092 | Formin FH2 Domain Inhibitor, SMIFH2 | 340316-62-3 | 10mg | $125 | 2024-03-01 | Buy |
| Sigma-Aldrich | S4826 | SMIFH2 ≥98% (HPLC) | 340316-62-3 | 25mg | $613 | 2024-03-01 | Buy |
| Tocris | 4401 | SMIFH2 ≥99%(HPLC) | 340316-62-3 | 10 | $125 | 2021-12-16 | Buy |
| Tocris | 4401 | SMIFH2 ≥99%(HPLC) | 340316-62-3 | 50 | $526 | 2021-12-16 | Buy |
SMIFH2 Chemical Properties,Uses,Production
Uses
SMIFH2 was used to decipher the role of mDia2 in controlling microtubule dynamics and myofibroblast differentiation.1
General Description
A cell-permeable thiooxodihydropyrimidinedione compound that inhibits both formin-mediated, profilin-independent actin nucleation (IC50 ~15 μM using mDia1 or mDia2) and formin-mediated elongation of actin filaments in the presence of profilin (IC50 ~4 μM using Cdc12 or mDia2), but not the Arp2/3-mediated or formin-independent actin assembly. SMIFH2 targets the FH2 (formin homology 2) domain of formins from a large variety of species, including murine mDia1/2, C. elegans CYK-1, S. pombe Cdc12, S. pombe Fus1, and S. cerevisiae Bni1, and decreases formin affinity for the actin filament barbed end. SMIFH2, at 25 μM, is shown to selectively disrupt formin-dependent actin cables and contractile rings, but not Arp2/3-dependent, CK-666- (Cat. No. 182515) sensitive actin patches, in fission yeast. SMIFH2 is also demonstrated to affect F-actin cytoskeleton structures and cell migration (by a 2-fold decrease at 10 μM) in NIH 3T3 fibroblast cultures.
Biochem/physiol Actions
SMIFH2 is an inhibitor of formin homology 2 domains. The compound is a first small molecule inhibitor of formin-mediated actin assembly that disrupts formin dependent processes from yeast to mammals. SMIFH2 may be a useful drug for identifying cellular processes dependent on formin-mediated actin assembly in a broad range of experimental systems. Formin is an actin nucleation factor.
storage
Store at +4°C
SMIFH2 Preparation Products And Raw materials
Raw materials
Preparation Products
SMIFH2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3418 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3413 | 55 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |