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Ganetespib

Ganetespib structure

CAS No.: 888216-25-9

Chemical Name:: Ganetespib

Synonyms: CS-654;SAT9090;STA-9090;Ganetespib;STA-9090;STA9090;Ganetespib, >=98%;STA-9090/Ganetespib;Ganetespib USP/EP/BP;Ganetespib (STA-9090);STA-9090; STA 9090; STA9090

CBNumber:: CB02566762

Molecular Formula:: C20H20N4O3

Molecular Weight:: 364.4

MDL Number:: MFCD22420818

MOL File:: 888216-25-9.mol

MSDS File:: SDS

Last updated:2023-07-09 14:26:36

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Ganetespib Properties

Density	1.39
storage temp.	-20°C
solubility	Soluble in DMSO (up to at least 25 mg/ml)
pka	7.38±0.20(Predicted)
form	solid
color	White
Stability	Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
NCI Dictionary of Cancer Terms	ganetespib
FDA UNII	2E8412Y946
NCI Drug Dictionary	ganetespib

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P280
HS Code	2933998090

Ganetespib price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	19432	Ganetespib ≥98%	888216-25-9	1mg	$49	2021-12-16	Buy
Cayman Chemical	19432	Ganetespib ≥98%	888216-25-9	5mg	$196	2021-12-16	Buy
Cayman Chemical	19432	Ganetespib ≥98%	888216-25-9	10mg	$294	2021-12-16	Buy
Cayman Chemical	19432	Ganetespib ≥98%	888216-25-9	25mg	$674	2021-12-16	Buy
Biorbyt Ltd	orb181166	Ganetespib(STA-9090) >98%	888216-25-9	100mg	$690.2	2021-12-16	Buy

Product number	Packaging	Price	Buy
19432	1mg	$49	Buy
19432	5mg	$196	Buy
19432	10mg	$294	Buy
19432	25mg	$674	Buy
orb181166	100mg	$690.2	Buy

Ganetespib Chemical Properties,Uses,Production

Description

Ganetespib, also known as STA-9090, is a unique resorcinolic triazolone inhibitor of Hsp90, which is currently in clinical trials for a number of human cancers. It has shown promise in preclinical tests against various cancers, including lung cancer, prostate cancer, and leukemia. Moreover, It has also shown strong activity toward breast cancer, non-small cell lung cancer, gastric cancer, and acute myeloid leukemia.

Definition

ChEBI: Ganetespib is a member of triazoles and a ring assembly. It is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.

General Description

A synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Ganetespib binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional HsP90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition.

target

HSP90

References

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer DOI:10.1158/1078-0432.CCR-11-2967
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ganetespib
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy DOI: 10.1158/1535-7163.MCT-11-0755
Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice doi: 10.3390/ijms24055014
A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies DOI:10.1186/1471-2407-13-152
Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner DOI:10.1038/cddis.2017.108

Ganetespib Preparation Products And Raw materials

Raw materials

Preparation Products

Ganetespib Suppliers

Global( 143)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29474	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9571	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Baoji Guokang Bio-Technology Co., Ltd.	58

View Lastest Price from Ganetespib manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	Ganetespib 888216-25-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	Ganetespib 888216-25-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-08-02	GANETESPIB 888216-25-9	US $1.00 / KG	1KG	95-99%	500kg/month	Career Henan Chemical Co

Ganetespib
888216-25-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Ganetespib
888216-25-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

GANETESPIB
888216-25-9
US $1.00 / KG
95-99%
Career Henan Chemical Co

Ganetespib Spectrum

Ganetespib(888216-25-9)¹HNMR

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Luminespib

1of4

5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one Ganetespib (STA-9090) 3H-1,2,4-Triazol-3-one, 5-[2,4-dihydroxy-5-(1-Methylethyl)phenyl]-2,4-dihydro-4-(1-Methyl-1H-indol-5-yl)- SAT9090 2,4-Dihydro-5-[2,4-dihydroxy-5-isopropylphenyl]-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one 5-{1,5-Dihydro-3-[2,4-dihydroxy-5-(prop-2-yl)phenyl]-5-oxo-4H-1,2,4-triazol-4-yl}-1-methyl-1H-indole, 4-[4,5-Dihydro-4-(1-methyl-1H-indol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-6-(prop-2-yl)benzene-1,3-di ol 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2H-1,2,4-triazol-3(4H)-one STA-9090/Ganetespib 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one Ganete ganetespib (Hsp90 inhibitor) 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-1H-1,2,4-triazol-5(4H)-one STA-9090;STA9090 GANETESPIB (STA-9090);STA-9090;STA 9090;STA9090 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-tria Ganetespib, >=98% Ganetespib STA-9090 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methylindol-5-yl)-5-hydroxy-4H-1,2,4-triazole STA9090; STA 9090; STA-9090; GANETESPIB STA-9090; STA 9090; STA9090 CS-654 3-[2,4-Dihydroxy-5-(propan-2-yl)phenyl]-4-(1-methyl-1H-indol-5-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one Ganetespib USP/EP/BP (5Z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-(1-methylindol-5-yl)-1,2,4-triazolidin-3-one 888216-25-9 Inhibitors