ChemicalBook >> CAS DataBase List >>3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide structure

CAS No.: 1009298-59-2

Chemical Name:: 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

Synonyms: CS-486;AZD2014;AZD2014, >=98%;AZD 2014; AZD-2014;AZD2014(Vistusertib);Vistusertib (AZD2014);Osimertinib Impurity 4;AZD2014;AZD 2014; AZD-2014;Vistusertib, 98%, a novel mTOR inhibitor;3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide

CBNumber:: CB02604239

Molecular Formula:: C25H30N6O3

Molecular Weight:: 462.54

MDL Number:: MFCD22628784

MOL File:: 1009298-59-2.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:20

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3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Properties

Melting point	233-237oC
Density	1.231
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	14.45±0.46(Predicted)
form	Solid
color	Light Yellow
FDA UNII	0BSC3P4H5X

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

HS Code

29339900

NFPA 704

	0
2		0

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17378	AZD 2014 ≥98%	1009298-59-2	1mg	$32	2024-03-01	Buy
Cayman Chemical	17378	AZD 2014 ≥98%	1009298-59-2	5mg	$93	2024-03-01	Buy
Cayman Chemical	17378	AZD 2014 ≥98%	1009298-59-2	10mg	$146	2024-03-01	Buy
Cayman Chemical	17378	AZD 2014 ≥98%	1009298-59-2	25mg	$305	2024-03-01	Buy
TRC	A808115	AZD2014	1009298-59-2	200mg	$890	2021-12-16	Buy

Product number	Packaging	Price	Buy
17378	1mg	$32	Buy
17378	5mg	$93	Buy
17378	10mg	$146	Buy
17378	25mg	$305	Buy
A808115	200mg	$890	Buy

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Chemical Properties,Uses,Production

Uses

AZD2014 is a dual mTORC1 and mTORC2 inhibitor. Studies show that AZD2014 induces growth inhibition and cell death in breast cancer cell lines, including ER+ cell lines.

Biological Activity

azd2014 is a novel, potent and highly selective dual inhibitor of the mammalian rapamycin (mtorc1 and mtorc2) with an ic50 value of 2.8 nm. it is an oral inhibitor and possesses potential antineoplastic activity.azd2014 enhanced susceptibility of glioblastoma stem-like cells (gscs) to irradiation both in vitro and under orthotopic in vivo conditions. kahn j et al pretreated cd133+ and cd15+ gsc cells with azd2014 (2 μm) for 1 hour, followed by irradiation. the effect was then measured by clonogenic survival analysis [2]. using in vitro screening, they demonstrated that the combination of ibrutinib, an inhibitor of the tyrosine kinase btk, and azd2014 could dramatically induce apoptosis in abc-subtype dlbcl cell lines. thereby, the combination of azd2014 with a btk inhibitor is a promising therapeutic method to cure patients with abc-type dlbcl [3]. in hepatocellular carcinoma cells, azd2014 gave rise to a more complete inhibition of mtorc1 than rapamycin, while the inhibition of mtorc2 prevented the feedback activation of akt signaling. therefore, azd2014 was identified to be more efficacious in the induction of apoptosis, autophagy, and cell cycle arrest, resulting in a significant proliferation suppression of the cells, in contrast with rapamycin [4].in a recent human pharmacokinetic and pharmacodynamic study, a dose of 50mg bd(twice a day)azd2014 was recommended to achieve pharmacologically relevant plasma concentrations [5].

target

mTOR

References

optimization of potent and selective dual mtorc1 and mtorc2 inhibitors: the discovery of azd8055 and azd2014. bioorg med chem lett. 2013 mar 1;23(5):1212-6. the mtorc1/mtorc2 inhibitor azd2014 enhances the radiosensitivity of glioblastoma stem-like cells. neuro oncol. 2014 jan;16(1):29-37. synergistic induction of apoptosis by combination of btk and dual mtorc1/2 inhibitors in diffuse large b cell lymphoma. oncotarget. 2014 jul 15;5(13):4990-5001.dramatic antitumor effects of the dual mtorc1 and mtorc2 inhibitor azd2014 in hepatocellular carcinoma. am j cancer res. 2014 dec 15;5(1):125-39. ecollection 2015.first-in-human pharmacokinetic and pharmacodynamic study of the dual m-torc 1/2 inhibitor, azd2014. clin cancer res. 2015 mar 24. pii: clincanres.2422.2014.

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Suppliers

Global( 154)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide 1009298-59-2	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
1009298-59-2
US $2.00 / kg
99%
Career Henan Chemical Co

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Spectrum

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide(1009298-59-2)¹HNMR

1009298-59-2(3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide)Related Search:

Everolimus INK 128 (MLN0128) BKM120 (NVP-BKM120, Buparlisib) AZD-8055 MK-2206 2HCl

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1,2,4-Benzenetriamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]- 2-Propenamide, N-[2-[[2-(dimethyloxidoamino)ethyl]methyloxidoamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]- 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

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3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide AZD2014 3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide AZD2014 AZD2014 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide 3-{2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-N-methylbenzamide AZD2014, >=98% AZD2014(Vistusertib) AZD2014;AZD 2014; AZD-2014 Vistusertib, 98%, a novel mTOR inhibitor Vistusertib (AZD2014) CS-486 AZD 2014; AZD-2014 Osimertinib Impurity 4 Benzamide, 3-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-N-methyl- 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide USP/EP/BP inhibit,Vistusertib,Apoptosis,Mammalian target of Rapamycin,AZD 2014,mTOR,Autophagy,Inhibitor,AZD-2014 1009298-59-2 Inhibitors Akt mTOR PI3K PI3K/Akt/mTOR