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Sofosbuvir

Indications and Usage Mechanisms of Action
Sofosbuvir
Sofosbuvir
CAS No.
1190307-88-0
Chemical Name:
Sofosbuvir
Synonyms
GS-7977;PSI 7977;Sofosbubir;sofosbuvir;Suofeibuwei;Sophy Bouvet;Sofosbuvir, >=98%;Sofosbuvir,GS-7977;GS-7977/sofosbuvir;sofosbuvir, PSI7977
CBNumber:
CB02604350
Molecular Formula:
C22H29FN3O9P
Formula Weight:
529.4525242
MOL File:
1190307-88-0.mol

Sofosbuvir Properties

Density 
1.41

SAFETY

Sofosbuvir price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15402 PSI-7977 ≥98% 1190307-88-0 1mg $58 2017-11-08 Buy
Cayman Chemical 15402 PSI-7977 ≥98% 1190307-88-0 5mg $145 2017-11-08 Buy
Cayman Chemical 15402 PSI-7977 ≥98% 1190307-88-0 10mg $261 2017-11-08 Buy

Sofosbuvir Chemical Properties,Uses,Production

Indications and Usage

Sofosbuvir is the world’s first oral drug for treating hepatitis C and was one of the most important new drugs to be approved in the U.S.A in 2013. It was developed by the American Gillard Scientific Company. It eliminates the need for traditional injection drug interferon (IFN) when treating genotype-specific hepatitis C.
Sofosbuvir is used to treat chronic hepatitis C virus (HCV) infections. It is the first safe and effective drug that does not require IFN when treating HCV infections. There are a few different types of HCV infections. According to the type of infection, treatment regimens can include sofosbuvir and ribavirin, or sofosbuvir, ribavirin and pegylated interferon α.

Mechanisms of Action

Sofosbuvir is a type of nucleotide analogue inhibitor. It prevents hepatitis C virus (HCV) from replicating a crucial type of specific protein.

Description

Sofosbuvir is a drug used for the treatment of hepatitis C. It is recommended to be used in combination with other drugs (such as velpatasvir) for the first-line treatment for HCV genotypes 1, 2, 3, 4, 5, and 6. It takes effect through acting as a nucleotide analog inhibitor, being capable of specially inhibiting the HCV NS5B (non-structural protein 5B) RNA-dependent RNA polymerase.

Uses

PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the t reatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Definition

ChEBI: A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.

Uses

PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.[Cayman Chemical]

Sofosbuvir Preparation Products And Raw materials

Raw materials

Preparation Products


Sofosbuvir Suppliers

Global( 210)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
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Capot Chemical Co.,Ltd.
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+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Henan Tianfu Chemical Co.,Ltd.
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Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
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Frapp's ChemicalNFTZ Co., Ltd.
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ChongQing Conscience Pharmaceuticals Ltd. +86-023- 68549356 023-68548079
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Jinan Kane Pharmaceutical Technology Co., Ltd. 0531-88603458 18678658680
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Zhengzhou Acme Chemical Co., Ltd. 0371-55282655 13346947059
0371-55282655 ssles1@acmechem.cn China 2781 58
AnHui HaiKang Pharmaceutical Co., Ltd. 0556-5800080 13335996519 18155647299
+86 (0556) 5800080 13335996519@163.com China 112 55

1190307-88-0(Sofosbuvir)Related Search:


  • 1334531-02-8
  • Sofosbuvir (PSI-7977, GS-7977)
  • Sofosbuvir N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester
  • propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
  • Suofeibuwei
  • API
  • Sofosbuvir, >=98%
  • Sofosbubir
  • Inhibitors
  • Sofosbuvir,GS-7977
  • Liver Disease Series
  • (S)-Isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-h
  • 1190307-88-0
  • GS-7977
  • N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester
  • PSI 7977
  • C22H29FN3O9P
  • sofosbuvir
  • GS-7977/sofosbuvir
  • sofosbuvir, PSI7977
  • PSI7977
  • (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(phenoxy)phosphoryl)aMino)propanoate
  • PSI-7977 Discontinued
  • Pharmaceutical intermediate
  • L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester
  • Sophy Bouvet
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