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acetyl Methanesulfonate

CAS No.
5539-53-7
Chemical Name:
acetyl Methanesulfonate
Synonyms
NSC 158252;Busulfan Impurity 6;Busulfan Impurity 10;Methanesulfonyl acetate;acetyl Methanesulfonate;Acetic acid, anhydride with methanesulfonic acid
CBNumber:
CB02610946
Molecular Formula:
C3H6O4S
Molecular Weight:
138.14
MDL Number:
MOL File:
5539-53-7.mol
Last updated:2023-04-23 13:52:06

acetyl Methanesulfonate Properties

Boiling point 56 °C(Press: 0.01 Torr)
Density 1.346±0.06 g/cm3(Predicted)
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility Chloroform (Sparingly)
form Oil
color Yellow
Stability Extremely Moisture Sensitive

acetyl Methanesulfonate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A173895 AcetylMethanesulfonate 5539-53-7 10g $755 2021-12-16 Buy
Product number Packaging Price Buy
A173895 10g $755 Buy

acetyl Methanesulfonate Chemical Properties,Uses,Production

Uses

Acetyl Methanesulfonate, is an impurity of Busulfan (B689900), an alkylating agent with antileukemic activity. Antineoplastic.

Purification Methods

The main impurity is methanesulfonic acid. Reflux it with redistilled acetyl chloride for 6-10hours, i.e. until no further HCl is absorbed in a trap, and exclude moisture. Distil off excess of AcCl and carefully distil it below 0.001mm with the bath temperature below 120o to give the anhydride as a pale yellow oil which solidifies below 0o. Below ~130o it gives the disulfonic anhydride, and above ~130o polymers are formed, and it is used for cleaving ethers [Preparation, IR, NMR: Karger & Mazur J Org Chem 36 528, 532 1971]. [Beilstein 2 H 166, 2 III 349.]

acetyl Methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC 158252 acetyl Methanesulfonate Methanesulfonyl acetate Busulfan Impurity 10 Acetic acid, anhydride with methanesulfonic acid Busulfan Impurity 6 5539-53-7