ChemicalBook >> CAS DataBase List >>DL-4-Chlorophenylalanine
DL-4-Chlorophenylalanine
- CAS No.
- 7424-00-2
- Chemical Name:
- DL-4-Chlorophenylalanine
- Synonyms
- PCP;P-CHLOROPHENYLALANINE;Fenclonine;4-CHLORO-DL-PHENYLALANINE;2-amino-3-(4-chlorophenyl)propanoic acid;2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID;c-pal;-4-ChL;cp10,188;NSC-77370
- CBNumber:
- CB0261841
- Molecular Formula:
- C9H10ClNO2
- Molecular Weight:
- 199.63
- MDL Number:
- MFCD00002601
- MOL File:
- 7424-00-2.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | >240 °C (dec.)(lit.) |
|---|---|
| Boiling point | 339.5±32.0 °C(Predicted) |
| Density | 1.2409 (rough estimate) |
| refractive index | 1.5790 (estimate) |
| storage temp. | room temp |
| solubility | Aqueous Acid (Slightly), Methanol (Slightly) |
| form | Powder |
| pka | pK1: 2.08(+1);pK2: 8.96(0) (25°C) |
| color | White to almost white |
| Water Solubility | slightly soluble |
| BRN | 2805758 |
| CAS DataBase Reference | 7424-00-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | R5J7E3L9SP |
| EPA Substance Registry System | 4-Chlorophenylalanine (7424-00-2) |
DL-4-Chlorophenylalanine price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6506 | 4-Chloro-DL-phenylalanine | 7424-00-2 | 5g | $148 | 2024-03-01 | Buy |
| Sigma-Aldrich | C6506 | 4-Chloro-DL-phenylalanine | 7424-00-2 | 25g | $547 | 2024-03-01 | Buy |
| TCI Chemical | C0253 | 4-Chloro-DL-phenylalanine >98.0%(T) | 7424-00-2 | 1g | $19 | 2024-03-01 | Buy |
| TCI Chemical | C0253 | 4-Chloro-DL-phenylalanine >98.0%(T) | 7424-00-2 | 25g | $248 | 2024-03-01 | Buy |
| Alfa Aesar | A13323 | 4-Chloro-DL-phenylalanine, 98+% | 7424-00-2 | 10g | $90.3 | 2024-03-01 | Buy |
DL-4-Chlorophenylalanine Chemical Properties,Uses,Production
Chemical Properties
Crystalline
Uses
4-Chloro-DL-phenylalanine has been used:
- as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
- to induce insomnia in rat models
- used to treat embryos to examine its effect on serotonin
- for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
- to feed flies to explore serotonin effect
Uses
4-Chloro-DL-phenylalanine is an irreversible tryptophan hydroxylase inhibitor that depletes serotonin in the brain.
Uses
An irreversible tryptophan hydroxylase inhibitor.
Definition
ChEBI: 2-amino-3-(4-chlorophenyl)propanoic acid is a phenylalanine derivative.
Biological Activity
4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.
Biochem/physiol Actions
4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.
Safety Profile
An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and Cl-.
in vivo
4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway.
storage
Room temperature
DL-4-Chlorophenylalanine Preparation Products And Raw materials
Global( 256)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
View Lastest Price from DL-4-Chlorophenylalanine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | DL-4-Chlorophenylalanine
7424-00-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-02 | 4-Chloro-DL-phenylalanine
7424-00-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-03-05 | DL-4-Chlorophenylalanine
7424-00-2
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- DL-4-Chlorophenylalanine
7424-00-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Chloro-DL-phenylalanine
7424-00-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- DL-4-Chlorophenylalanine
7424-00-2
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co
7424-00-2(DL-4-Chlorophenylalanine)Related Search:
DL-O-CHLOROPHENYLALANINE
DL-P-CHLOROPHENYLALANINE METHYL ESTER*HY,DL-4-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE,DL-P-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
DL-PENICILLAMINE
2-FLUORO-DL-PHENYLALANINE
4-Iodo-DL-phenylalanine
4-BROMO-DL-PHENYLALANINE
3-(3-Hydroxyphenyl)-DL-alanine
DL-4-Cyanophenylalanine
2-AMINO-3-(3-METHOXY-PHENYL)-PROPIONIC ACID
2-Bromo-DL-Phenylalanine
1of4
(±)-3-(4-Chlorophenyl)-2-aminopropanoic acid
NSC-77370
DL-4-Chloro-phe-OH
DL-Phe(4-Cl)-OH 4-Chloro-DL-Phenylalanine
H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA
4-Chloro-DL-phenylalanine, 98+%
DL-4-Chlorophenylalanine, 98+%, 98+%
DL-2-Amino-3-(4-chloro-phenyl)-propionic acid
4-Chloro-DL-phenylalanine (PCPA)
Fenchlonine(PCPA)
4-CHLOROPHENYLALANINE
DL-4-CHLOROPHENYLALANINE
DL-P-CHLOROPHENYLALANINE
fenclonin
(RS)-2-Amino-3-(4-chlorophenyl)propionic acid
4-Chloro-DL-phenylalanine≥ 99% (HPLC)
(+/-)-P-CHLOROPHENYLALANINE, (P-CPA) CAU SES DEPLETION OF S
DL-P-CHLOROPHENYLALANINE CRYSTALLINE
4-Chloro-Dl-Phenylalanine,>99%
3-(4-CHLOROPHENYL)ALANINE,DL-
DL-Phe(4-Cl)-OH
3-(4-Chlorophenyl)-DL-alanine
DL-4-Chlorophenylalanine, 98+%
PCP, PCPA
(2R)-2-Azaniumyl-3-(4-chlorophenyl)propanoate
Alanine, 3-(p-chlorophenyl)-
3-(p-chlorophenyl)-DL-alanine
P-chloro benzoic acetate
(+-)-p-chlorphenylalanine
cp10,188
c-pal
H-DL-PHE(4-CL)-OH
LABOTEST-BB LT00453604
H-P-CHLORO-DL-PHE-OH
TIMTEC-BB SBB003551
P-CHLORO-DL-PHENYLALANINE
fenchlonine
(2S)-2-ammonio-3-(4-chlorophenyl)propanoate
4-Chloro-DL-phenylalanine >
Chloro DL
Phenylalanine, 4-chloro-
-4-ChL
DL-4-Chlorophenylalanine USP/EP/BP
p-Chlorophenylalanin
Fenclonine (PCPA
2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID
4-CHLORO-DL-PHENYLALANINE
Fenclonine
2-amino-3-(4-chlorophenyl)propanoic acid
PCP
P-CHLOROPHENYLALANINE
Contezolid Impurity 9
4-Chloro-DL-phenylalanine, ≥ 98.0%
7424-00-2
7724-00-2
Peptide Synthesis
Phenylalanine Derivatives
Unnatural Amino Acid Derivatives