PI-103 (Hydrochloride)
- CAS No.
- 371935-79-4
- Chemical Name:
- PI-103 (Hydrochloride)
- Synonyms
- PI-103 HCl;PI103 Free base;PI-103, Hydrochloride Salt, >99%;PI 103 HYDROCHLORIDE;PI103 HYDROCHLORIDE;3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol,hydrochloride;3-[4-(4-Morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol monohydrochloride
- CBNumber:
- CB02624280
- Molecular Formula:
- C19H17ClN4O3
- Molecular Weight:
- 384.81628
- MDL Number:
- MOL File:
- 371935-79-4.mol
- MSDS File:
- SDS
PI-103 (Hydrochloride) price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21187 | PI-103 (hydrochloride) ≥98% | 371935-79-4 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 21187 | PI-103 (hydrochloride) ≥98% | 371935-79-4 | 5mg | $160 | 2024-03-01 | Buy |
| Cayman Chemical | 21187 | PI-103 (hydrochloride) ≥98% | 371935-79-4 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 21187 | PI-103 (hydrochloride) ≥98% | 371935-79-4 | 50mg | $510 | 2024-03-01 | Buy |
| Biorbyt Ltd | orb153627 | PI-103, Free Base >99% pure | 371935-79-4 | 50mg | $532.1 | 2021-12-16 | Buy |
PI-103 (Hydrochloride) Chemical Properties,Uses,Production
Biological Activity
pi-103 is a dual inhibitor of pi3k/akt and mtor with ic50 value of 0.002 μm , 0.003μm, 0.003μm, 0.015μm, 0.030μm for p110α, p110β, p110γ, p110 and mtor, respectively [1].pi3k/akt/mtor pathway is an intracellular signaling pathway and plays an important role in regulating cell cycle. it has been shown that pi3k/akt/mtor pathway is directly related to cellular quiescence, proliferation, cancer, and longevity. and many studies have shown that activation of the pi3k/akt signaling pathway is correlated with poor prognosis in a variety of cancers which demonstrated that inhibition of the pathway may be regarded as a promising therapy [2, 3].pi-103 is a selective pi3k/akt and mtorc1 inhibitor. when tested with leukemic cell lines (molm14, oci-aml3 and mv4-11) with activation of pi3k/akt, mtorc1 and erk/mapk signaling pathways, pi-103 blocked cells proliferation via inhibiting pi3k/akt and mtorc1 activity in a concentration of 1μm [4]. in hcc cell line--huh7 cells, treated pi-103 alone or combined with sorafenib inhibited cells proliferation in a dose-dependent manner through inhibition of pi3k/akt and mtorc1 pathways [5]. when tested with u87mg glioblastoma cells, pi-103 treatment in 30 nm/l showed significant inhibition of pi3k/akt and mtorc1 phosphorylation [1]. in neuroblastoma cell lines sk-n-be (2), imr-32 with amplified mycn, pi-103 inhibited cell growth in a time- and concentration-dependent manner via inhibiting pi3k/akt and mtorc1 activity [3].in sk-n-be (2) with mycn-mutant xenografted nude mice model, treated pi-103 intraperitoneally (10 mg/kg) markedly reduced the tumor volume index and tumor weight via inhibiting pi3k/ mtor pathways [1].
storage
+4°C (desiccate)
References
[1]. raynaud, f.i., et al., biological properties of potent inhibitors of class i phosphatidylinositide 3-kinases: from pi-103 through pi-540, pi-620 to the oral agent gdc-0941. mol cancer ther, 2009. 8(7): p. 1725-38.
[2]. hambright, h.g., et al., inhibition of pi3k/akt/mtor axis disrupts oxidative stress-mediated survival of melanoma cells. oncotarget, 2015.
[3]. segerstrom, l., et al., effects of small molecule inhibitors of pi3k/akt/mtor signaling on neuroblastoma growth in vitro and in vivo. int j cancer, 2011. 129(12): p. 2958-65.
[4]. park, s., et al., pi-103, a dual inhibitor of class ia phosphatidylinositide 3-kinase and mtor, has antileukemic activity in aml. leukemia, 2008. 22(9): p. 1698-706.
[5]. gedaly, r., et al., pi-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking ras/raf/mapk and pi3k/akt/mtor pathways. anticancer res, 2010. 30(12): p. 4951-8.
PI-103 (Hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
PI-103 (Hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Suzhou yacoo science co.,Ltd | 0512-87182056 18013166090 | lingling.qi@yacoo.com.cn | China | 7300 | 60 |