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BMS 201038-04

BMS 201038-04 structure

CAS No.: 202914-84-9

Chemical Name:: BMS 201038-04

Synonyms: BMS 201038-04;AEGR733 Mesylate;AEGR 733 Mesylate;AEGR-733 Mesylate;BMS201038 Mesylate;BMS-201038 Mesylate;BMS 201038 Mesylate;LoMitapide Mesylate;BMS 201038-04 USP/EP/BP;BMS201038/LoMitapide Mesylate

CBNumber:: CB02627605

Molecular Formula:: C40H41F6N3O5S

Molecular Weight:: 789.8260592

MDL Number:: MFCD19443682

MOL File:: 202914-84-9.mol

Last updated:2023-05-18 11:31:04

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BMS 201038-04 Properties

storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO:100.0(Max Conc. mg/mL);126.61(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);126.61(Max Conc. mM)
CAS DataBase Reference	202914-84-9
FDA UNII	X4S83CP54E

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360-H351-H413
Precautionary statements	P201-P202-P281-P308+P313-P405-P501

BMS 201038-04 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0013823	BMS-201038-04 95.00%	202914-84-9	5MG	$498.41	2021-12-16	Buy
AK Scientific	2522AH	Lomitapidemesylate	202914-84-9	50mg	$513	2021-12-16	Buy
DC Chemicals	DC8428	LomitapideMesylate >98%	202914-84-9	250mg	$650	2021-12-16	Buy
DC Chemicals	DC8428	LomitapideMesylate >98%	202914-84-9	1g	$1450	2021-12-16	Buy
Ambeed	A615945	Lomitapidemesylate 98+%	202914-84-9	5mg	$75	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0013823	5MG	$498.41	Buy
2522AH	50mg	$513	Buy
DC8428	250mg	$650	Buy
DC8428	1g	$1450	Buy
A615945	5mg	$75	Buy

BMS 201038-04 Chemical Properties,Uses,Production

Description

Lomitapide is an orally active microsomal triglyceride transfer protein (MTP) inhibitor for the treatment of hypercholesterolemia. The drug was developed by Aegerion Pharmaceuticals Inc. and licensed to Bristol–Myers Squibb Co. and the University of Pennsylvania. Lomitapide effectively lowered LDL–cholesterol, both as a single agent and in combination with commonly prescribed lipid-lowering therapies. Sold under the trade name Juxtapid, the drug offers a new treatment option to patients who cannot tolerate statin therapy or who experience insufficient LDL–cholesterol reduction with the currently available therapies, such as patients with homozygous familial hypercholesterolemia caused by mutations in the LDLR gene.

Definition

ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of lomitapide and methanesulfonic acid. Used as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.

Synthesis

Commercial 9H-fluorene-9-carboxylic acid (105) was alkylated with 1,4-dibromobutane in the presence of n-butyl lithium in THF to give 9-(4-bromobutyl)-9H-fluorene-9-carboxylic acid (106) in 85% yield. Next, activation of the acid as the acid chloride followed by coupling with (2,2,2-trifluoroethylamine) provided amide 107 in 71% yield for the two-step sequence. Displacement of the terminal bromide with the appropriate 4-carbamoyl piperidine followed by removal of the Boc group furnished piperidinyl fluorine 108 in high yield. Amine 108 was then reacted with the acid chloride derived from acid 109 (derived from the Suzuki coupling of boronic acid 110 and o-iodobenzoic acid 111) to give lomitapide, and this was followed by salt formation with methanesulfonic acid to afford lomitapide mesylate (XIV).

Synthesis_202914-84-9

BMS 201038-04 Preparation Products And Raw materials

Raw materials

Preparation Products

BMS 201038-04 Suppliers

Global( 71)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Hebei Miaoyin Technology Co.,Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from BMS 201038-04 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-17	BMS 201038-04 USP/EP/BP 202914-84-9	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
	2019-12-24	Lomitapide Mesylate 202914-84-9	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

BMS 201038-04 USP/EP/BP
202914-84-9
US $1.10 / g
99.9%
Dideu Industries Group Limited

Lomitapide Mesylate
202914-84-9
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

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BMS 201038-04 LoMitapide Mesylate BMS 201038 methanesulfonic acid salt AEGR 733 Mesylate AEGR733 Mesylate AEGR-733 Mesylate BMS 201038 Mesylate BMS201038 Mesylate BMS-201038 Mesylate N-(2,2,2-trifluorethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate BMS201038/LoMitapide Mesylate BMS 201038-04 USP/EP/BP Inhibitor,Lomitapide,Lomitapide Mesylate,AEGR-733,inhibit,AEGR 733,BMS-201038,AEGR733,BMS201038,BMS 201038 N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate[AEGR-733 Mesylate N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate 202914-84-9 C39H37F6N3O2xCH4O3S C40H41F6N3O5S Inhibitors