AVL-292
- CAS No.
- 1202757-89-8
- Chemical Name:
- AVL-292
- Synonyms
- CC-292;CS-733;LMK-435;AVL-292;Spebrutinib;AVL-292 >=98%;CC-292,LMK-435;CC-292 (AVL-292);AVL 292 - CC 292;AVL-292 USP/EP/BP
- CBNumber:
- CB02655392
- Molecular Formula:
- C22H22FN5O3
- Molecular Weight:
- 423.44
- MDL Number:
- MFCD25976876
- MOL File:
- 1202757-89-8.mol
| Density | 1.322±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| pka | 13.22±0.70(Predicted) |
| CAS DataBase Reference | 1202757-89-8 |
| FDA UNII | DRU6NG543J |
AVL-292 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17993 | AVL-292 ≥98% | 1202757-89-8 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17993 | AVL-292 ≥98% | 1202757-89-8 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 17993 | AVL-292 ≥98% | 1202757-89-8 | 10mg | $341 | 2024-03-01 | Buy |
| Cayman Chemical | 17993 | AVL-292 ≥98% | 1202757-89-8 | 50mg | $957 | 2024-03-01 | Buy |
| TRC | A794715 | AVL-292 | 1202757-89-8 | 100mg | $610 | 2021-12-16 | Buy |
AVL-292 Chemical Properties,Uses,Production
Uses
Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]
target
Btk
AVL-292 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
