MACULOSIN
- CAS No.
- 4549-02-4
- Chemical Name:
- MACULOSIN
- Synonyms
- A-19C;0/4/49;ML-1532II;MACULOSIN;Maculosin TFA;CYCLO(-PRO-TYR);Antibiotic A-19C;cyclo(L-Pro-L-Tyr);Cyclo(L-Tyr-L-Pro-);MACULOSIN USP/EP/BP
- CBNumber:
- CB0265753
- Molecular Formula:
- C14H16N2O3
- Molecular Weight:
- 260.29
- MDL Number:
- MFCD03093467
- MOL File:
- 4549-02-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H311-H331-H371 | |||||||||
| Precautionary statements | P280-P302+P352-P312-P322-P361-P363-P405-P501-P260-P264-P270-P309+P311-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
MACULOSIN price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25019 | Maculosin ≥95% | 4549-02-4 | 5mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 25019 | Maculosin ≥95% | 4549-02-4 | 25mg | $416 | 2024-03-01 | Buy |
| TRC | C988385 | Cyclo(L-prolinyl-L-tyrosine) | 4549-02-4 | 25mg | $385 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC108323 | Cyclo(-Pro-Tyr) | 4549-02-4 | 500mg | $155 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC108323 | Cyclo(-Pro-Tyr) | 4549-02-4 | 1g | $273 | 2021-12-16 | Buy |
MACULOSIN Chemical Properties,Uses,Production
Description
Maculosin is a diketopiperazine metabolite produced by A. alternata, L. capsici, Streptomyces, and the Gram-negative, nonobligate predator bacterial strain 679-2. It acts as a host-specific phytotoxin, inducing formation of weeping necrotic lesions in leaves of spotted knapweed (C. maculosa) when used at a concentration of 10 μM. Maculosin reduces the growth of the plant pathogenic bacteria X. axonopodis and R. solanacearum (MICs = 31.25 μg/ml) as well as the pathogenic oomycetes P. cactorum, P. capsici, P. cinnamomi, P. infestans, and P. ultimum when used at concentrations ranging from 10 to 100 mg/ml. Maculosin also inhibits the growth of M. luteus, M. smegmatis, S. cerevisiae, C. albicans, C. neoformans, and A. niger when used in combination with pyrrolnitrin or banegasin.
Uses
Cyclo(L-prolinyl-L-tyrosine) is a diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus.
Uses
Cyclo(L-Pro-L-Tyr) (maculosin) is a diketopiperazine formed by the fusion of tyrosine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(L-Pro-L-Tyr) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(L-Pro-L-Tyr) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of cyclo(L-Pro-L-Tyr) is not known, its activity suggests the existence of cross talk among bacterial signalling systems. Cyclo(L-Pro-L-Tyr) was identified as a host-specific toxin produced by Alternaria alternata on spotted knapweed.
Definition
ChEBI: A homodetic cyclic peptide that is a dipeptide composed of L-proline and L-tyrosine joined by peptide linkages.
MACULOSIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9365 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | sales@shringchem.com | China | 3545 | 58 |
