ChemicalBook >> CAS DataBase List >>INNO206
INNO206
- CAS No.
- 1361644-26-9
- Chemical Name:
- INNO206
- Synonyms
- Aldoxorubicin;Aldoxorubicin (INNO-206);Aldoxorubicin Aldoxorubicin;DoxorubicinImpurity16Trifluoroacetate;N-[(E)-[1-[(2S,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-hydroxyethylidene]amino]-6-(2,5-dioxopyrrol-1-yl)hexanamide;1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (2E)-2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide;(E)-N’-[1-[(2S,4S)-4-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanehydrazide;N'-((E)-1-((2S,4S)-4-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)-2-hydroxyethylidene)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide
- CBNumber:
- CB02666640
- Molecular Formula:
- C37H42N4O13
- Molecular Weight:
- 750.75
- MDL Number:
- MOL File:
- 1361644-26-9.mol
Last updated:2023-05-21 10:59:17
| Density | 1.60±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | -80°, stored under nitrogen,unstable in solution, ready to use. |
| solubility | DMSO : 75 mg/mL (99.90 mM) |
| pka | 7.36±0.60(Predicted) |
| FDA UNII | C28MV4IM0B |
| NCI Drug Dictionary | aldoxorubicin |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H340-H350-H360 |
INNO206 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1186 | Aldoxorubicin 95.99% | 1361644-26-9 | 5mg | $135 | 2021-12-16 | Buy |
| ChemScene | CS-1186 | Aldoxorubicin 95.99% | 1361644-26-9 | 10mg | $174 | 2021-12-16 | Buy |
| ChemScene | CS-1186 | Aldoxorubicin 95.99% | 1361644-26-9 | 50mg | $695 | 2021-12-16 | Buy |
| ChemScene | CS-1186 | Aldoxorubicin 95.99% | 1361644-26-9 | 100mg | $1180 | 2021-12-16 | Buy |
| Ambeed | A664813 | Inno-206 98+% | 1361644-26-9 | 100mg | $1143 | 2021-12-16 | Buy |
INNO206 Chemical Properties,Uses,Production
Biological Activity
Aldoxorubicin (INNO-206) is an albumin-bound prodrug of doxorubicin, a DNA topoisomerase II inhibitor, released from albumin under acidic conditions. It has potent antitumor activity in various cancer cell lines and mouse tumor models.
in vitro
Aldoxorubicin (INNO-206) (0.27 to 2.16 μM) inhibits blood vessel formation and reduces multiple myeloma cell growth in a pH-dependent fashion.
in vivo
Aldoxorubicin (INNO-206) (10.8 mg/kg, i.v.) shows significantly smaller tumor volumes and IgG levels on days 28, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor.
target
| Topoisomerase II
| Daunorubicins/Doxorubicins
|
INNO206 Preparation Products And Raw materials
Raw materials
Preparation Products
INNO206 Suppliers
Global( 34)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ChemExpress | +86-021-58950125 | info@chemexpress.com | China | 557 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| ChemExpress | 58 |
| Labnetwork lnc. | 58 |
| InvivoChem | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | 58 |
| Aladdin Scientific | 58 |
| Amadis Chemical Company Limited | 58 |
| Haoyuan Chemexpress Co., Ltd. | 61 |
| LETOPHARM LIMITED | 58 |
| BOC Sciences | 65 |
Aldoxorubicin
Aldoxorubicin (INNO-206)
N-[(E)-[1-[(2S,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-hydroxyethylidene]amino]-6-(2,5-dioxopyrrol-1-yl)hexanamide
(E)-N’-[1-[(2S,4S)-4-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanehydrazide
Aldoxorubicin Aldoxorubicin
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (2E)-2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
DoxorubicinImpurity16Trifluoroacetate
N'-((E)-1-((2S,4S)-4-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)-2-hydroxyethylidene)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide
1361644-26-9