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MK 5172 potassiuM salt

MK 5172 potassiuM salt Structure
MK 5172 potassiuM salt structure
CAS No.
1206524-86-8
Chemical Name:
MK 5172 potassiuM salt
Synonyms
MK-5172 Potassium;Grazoprevir potassium;MK5172 potassiuM salt;MK 5172 potassiuM salt;MK-5172 (potassiuM salt);Grazoprevir potassiuM salt;2)-ether potassium salt (1:1);Grazoprevir (MK-5172) potassium salt;GRAZOPREVIR POTASSIUM SALT;MK5172 POTASSIUM SALT;MK 5172 POTASSIUM SALT;(1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcCyclopropanecarboxamide cyclic (1-2)-ether potassium salt (1:1)
CBNumber:
CB02666660
Molecular Formula:
C38H49N6O9S.K
Molecular Weight:
807.02
MDL Number:
MFCD25976701
MOL File:
1206524-86-8.mol
Last updated:2023-05-21 10:59:17
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MK 5172 potassiuM salt Properties

storage temp. Store at -20°C
solubility DMSO:100.0(Max Conc. mg/mL);124.22(Max Conc. mM)
form Powder

MK 5172 potassiuM salt price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-1375 Grazoprevirpotassiumsalt 99.40% 1206524-86-8 5mg $108 2021-12-16 Buy
ApexBio Technology A3620 MK-5172potassiumsalt 1206524-86-8 1mg $126 2021-12-16 Buy
ChemScene CS-1375 Grazoprevirpotassiumsalt 99.40% 1206524-86-8 10mg $168 2021-12-16 Buy
ChemScene CS-1375 Grazoprevirpotassiumsalt 99.40% 1206524-86-8 50mg $540 2021-12-16 Buy
ChemScene CS-1375 Grazoprevirpotassiumsalt 99.40% 1206524-86-8 100mg $780 2021-12-16 Buy
Product number Packaging Price Buy
CS-1375 5mg $108 Buy
A3620 1mg $126 Buy
CS-1375 10mg $168 Buy
CS-1375 50mg $540 Buy
CS-1375 100mg $780 Buy

MK 5172 potassiuM salt Chemical Properties,Uses,Production

Description

MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. IC50 Value: 7.4 nM and 7 nM for genotype 1b and 1a respectively, in replicon system [1] Target: HCV NS3/4a protease

in vitro

in vitro: In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a [2].

in vivo

in vivo: In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM.hr. The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i.v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 uM.hr) after a p.o. 1 mg/kg dose [1]. Clinical trial: Evaluation of Hepatic Pharmacokinetics for MK-5172 in Participants With Chronic Hepatitis C . Phase1

References

References:[1]. Steven Harper , John A. McCauley , Michael T. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. ACS Med. Chem. Lett., 2012, 3 (4), pp 332-336 [2]. Summa V, Ludmerer SW, McCauley JA, MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7.

MK 5172 potassiuM salt Preparation Products And Raw materials

Raw materials

Preparation Products

MK 5172 potassiuM salt Suppliers

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
ZHEJIANG JIUZHOU CHEM CO., LTD 		+86-0576225566889 +86-13454675544 admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com China 20000 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810 sales@anbuchem.com China 3000 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3419 58
Supplier Advantage
career henan chemical co 		58
Chongqing Chemdad Co., Ltd 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
ZHEJIANG JIUZHOU CHEM CO., LTD 		58
Zhengzhou Anbu Chem Co.,Ltd 		58
Amadis Chemical Company Limited 		58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58

View Lastest Price from MK 5172 potassiuM salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MK 5172 potassiuM salt pictures 2019-07-06 MK 5172 potassiuM salt
1206524-86-8
 US $2.00 / kg 1kg 99% ask Career Henan Chemical Co

1206524-86-8(MK 5172 potassiuM salt)Related Search:

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2)-ether potassium salt (1:1) Grazoprevir potassiuM salt (1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcCyclopropanecarboxamide cyclic (1-2)-ether potassium salt (1:1) MK 5172 potassiuM salt MK-5172 (potassiuM salt) MK5172 potassiuM salt GRAZOPREVIR POTASSIUM SALT;MK5172 POTASSIUM SALT;MK 5172 POTASSIUM SALT Grazoprevir (MK-5172) potassium salt MK-5172 Potassium Grazoprevir potassium 1206524-86-8 C38H49N6O9SK C38H50KN6O9S