ChemicalBook >> CAS DataBase List >>CNX-774
CNX-774
- CAS No.
- 1202759-32-7
- Chemical Name:
- CNX-774
- Synonyms
- CS-946;CNX-77;CNX-774;CNX-774(97 %);CNX774; CNX 774;CNX-774 USP/EP/BP;4-(4-((4-(acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide;4-(4-((4-((3-Acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamid;4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide;4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
- CBNumber:
- CB02666837
- Molecular Formula:
- C26H22FN7O3
- Molecular Weight:
- 499.5
- MDL Number:
- MFCD26405992
- MOL File:
- 1202759-32-7.mol
- MSDS File:
- SDS
Last updated:2023-09-20 16:43:00
| Density | 1.383±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20° C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 13.22±0.70(Predicted) |
| CAS DataBase Reference | 1202759-32-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
CNX-774 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21475 | CNX-774 ≥98% | 1202759-32-7 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 21475 | CNX-774 ≥98% | 1202759-32-7 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 21475 | CNX-774 ≥98% | 1202759-32-7 | 10mg | $223 | 2024-03-01 | Buy |
| Cayman Chemical | 21475 | CNX-774 ≥98% | 1202759-32-7 | 25mg | $469 | 2024-03-01 | Buy |
| TRC | C600000 | CNX-774 | 1202759-32-7 | 5mg | $120 | 2021-12-16 | Buy |
CNX-774 Chemical Properties,Uses,Production
Uses
CNX-774 is an irreversible, orally active, and highly selective inhibitor of Bruton’s tyrosine kinase (BTK) and can be used for the treatment of rheumatoid arthritis (RA).
Biological Activity
cnx-774 is an orally active and selective inhibitor of btk with ic50 value of <1 nm.bruton’s tyrosine kinase (btk) is an important enzyme in the b-cell antigen receptor (bcr) signaling pathway and also plays an important role in mast cell activation and b cell maturation.cnx-774 is an orally active, irreversible and selective btk inhibitor with ic50 value of <1 nm. cnx-774 formed covalent bond with the cys481 residue within the atp binding site of btk. in cellular assays, cnx-774 inhibited btk with ic50 values of 1-10 nm [1].
References
[1]. akinleye a, chen y, mukhi n, et al. ibrutinib and novel btk inhibitors in clinical development. j hematol oncol, 2013, 6: 59.
CNX-774 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 110)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29321 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
1202759-32-7(CNX-774)Related Search:
CNX-774
4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide CNX-774
4-(4-((4-((3-Acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamid
2-Pyridinecarboxamide, 4-[4-[[5-fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-
4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
CNX774; CNX 774
4-(4-((4-(acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
CS-946
CNX-774(97 %)
CNX-774 USP/EP/BP
CNX-77
1202759-32-7
C26H22FN7O3
Inhibitors
API