ChemicalBook >> CAS DataBase List >>NSC 55712
NSC 55712
- CAS No.
- 2076-91-7
- Chemical Name:
- NSC 55712
- Synonyms
- R 55;NSC 55712;TPT-260 2HCl;TPT-260 , NSC55712;TPT-260 2HCl (R55);TPT-260 2HCl(NSC55712);TPT-260 (hydrochloride);TPU-260 Dihydrochloride;NSC55712 Dihydrochloride;TPT-260 (Dihydrochloride)
- CBNumber:
- CB02667773
- Molecular Formula:
- C8H14Cl2N4S3
- Molecular Weight:
- 333.32456
- MDL Number:
- MFCD25976641
- MOL File:
- 2076-91-7.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:02:16
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| NFPA 704 |
|
NSC 55712 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16079 | TPT-260 (hydrochloride) ≥95% | 2076-91-7 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16079 | TPT-260 (hydrochloride) ≥95% | 2076-91-7 | 5mg | $140 | 2024-03-01 | Buy |
| Cayman Chemical | 16079 | TPT-260 (hydrochloride) ≥95% | 2076-91-7 | 10mg | $235 | 2024-03-01 | Buy |
| Cayman Chemical | 16079 | TPT-260 (hydrochloride) ≥95% | 2076-91-7 | 25mg | $479 | 2024-03-01 | Buy |
| AK Scientific | SYN5349 | R55 | 2076-91-7 | 50mg | $757 | 2021-12-16 | Buy |
NSC 55712 Chemical Properties,Uses,Production
Uses
Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.[Cayman Chemical]
NSC 55712 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 54)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
NSC 55712
TPT-260 (Dihydrochloride)
THIOPHENE-2,5-DIYLBIS(METHYLENE) DICARBAMIMIDOTHIOATE.2HCL
TPT-260 (Dihydrochloride), NSC55712
TPT-260 2HCl
Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
TPT-260 , NSC55712
NSC 55712 Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
TPT-260 Dihydrochloride, >=98%
Thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride
NSC55712 Dihydrochloride
TPT-260 2HCl(NSC55712)
R 55
TPT-260 (hydrochloride)
thiene-2,5-diyldimethanediyl dicarbamimidothioate
Carbamimidothioic acid,C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)
NSC55712; TPT260 DIHYDROCHLORIDE; TPT 260 DIHYDROCHLORIDE; TPU-260 DIHYDROCHLORIDE;NSC-55712;NSC 55712
TPU-260 Dihydrochloride
[({5-[(carbamimidoylsulfanyl)methyl]thiophen-2-yl}methyl)sulfanyl]methanimidamide dihydrochloride
TPT-260 2HCl (R55)
TPT 260 Dihydrochloride,Inhibitor,inhibit,TPU 260,TPU260,TPT260 Dihydrochloride,NSC 55712,TPU-260,NSC-55712
2076-91-7
C8H12N4S32HCl
C8H14Cl2N4S3
C8H12N4S32ClH
Inhibitors