ChemicalBook >> CAS DataBase List >>Cabotegravir (GSK744, GSK1265744)

Cabotegravir (GSK744, GSK1265744)

CAS No.
1051375-10-0
Chemical Name:
Cabotegravir (GSK744, GSK1265744)
Synonyms
Cabotegravir;GSK1265744;GSK744;CS-2197;Caboteve;Cabot wei;SureCN82803;S/GSK1265744;Cabotegravin;SK744, GSK1265744
CBNumber:
CB02668664
Molecular Formula:
C19H17F2N3O5
Molecular Weight:
405.35
MDL Number:
MFCD25976748
MOL File:
1051375-10-0.mol
MSDS File:
SDS
Last updated:2023-12-19 10:55:19

Cabotegravir (GSK744, GSK1265744) Properties

Boiling point 664.0±55.0 °C(Predicted)
Density 1.57±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming
form solid
pka 4.50±1.00(Predicted)
FDA UNII HMH0132Z1Q
ATC code J05AJ04

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H400-H410
Precautionary statements  P273-P391-P501-P273-P391-P501

Cabotegravir (GSK744, GSK1265744) price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27215 GSK744 1051375-10-0 5mg $32 2024-03-01 Buy
Cayman Chemical 27215 GSK744 1051375-10-0 10mg $61 2024-03-01 Buy
Cayman Chemical 27215 GSK744 1051375-10-0 25mg $131 2024-03-01 Buy
Cayman Chemical 27215 GSK744 1051375-10-0 50mg $243 2024-03-01 Buy
TRC C050100 Cabotegravir 1051375-10-0 100mg $910 2021-12-16 Buy
Product number Packaging Price Buy
27215 5mg $32 Buy
27215 10mg $61 Buy
27215 25mg $131 Buy
27215 50mg $243 Buy
C050100 100mg $910 Buy

Cabotegravir (GSK744, GSK1265744) Chemical Properties,Uses,Production

Uses

Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.

Definition

ChEBI: Cabotegravir is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It is a difluorobenzene, a secondary carboxamide, a monocarboxylic acid amide and an organic heterotricyclic compound. It is a conjugate acid of a cabotegravir(1-).

Biological Activity

Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2.

Mechanism of action

Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself.

target

HIV integrase

Cabotegravir (GSK744, GSK1265744) Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 146)Suppliers
Supplier Tel Email Country ProdList Advantage
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Guangzhou Tengyue Chemical Co., Ltd.
+86-86-18148706580 +8618826483838 evan@tyvovo.com China 146 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14764 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Shochem(Shanghai) Co.,Ltd
86-21-50800795 info@shochem.com CHINA 288 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58

Related articles

  • How is GSK744 synthesised?
  • GSK744 (Cabotegravir) is synthesised using Cabotegravir Pyridinone as a raw material through a series of chemical reactions.
  • Dec 19,2023

View Lastest Price from Cabotegravir (GSK744, GSK1265744) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cabotegravir (GSK744, GSK1265744) pictures 2023-11-16 Cabotegravir (GSK744, GSK1265744)
1051375-10-0
US $240.00 / g 10g 99% Purity (What/sapp: +86 18145728414) 1000 Tons/Month Guangzhou Tengyue Chemical Co., Ltd.
SureCN82803 pictures 2021-07-02 SureCN82803
1051375-10-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Cabotegravir pictures 2020-11-16 Cabotegravir
1051375-10-0
US $20.00 / KG 1KG 99% 1000KG Longyan Tianhua Biological Technology Co., Ltd
  • SureCN82803 pictures
  • SureCN82803
    1051375-10-0
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Cabotegravir pictures
  • Cabotegravir
    1051375-10-0
  • US $20.00 / KG
  • 99%
  • Longyan Tianhua Biological Technology Co., Ltd

Cabotegravir (GSK744, GSK1265744) Spectrum

1051375-10-0(Cabotegravir (GSK744, GSK1265744))Related Search:

GSK744 (3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide Cabotegravir (GSK744, GSK1265744) Cabotegravir Free Acid Cyclic pyranopterin SK744, GSK1265744 Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)- S/GSK1265744 (3S,11AR)-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXAMIDE Cabotegravir(GSK1265744A,GSK-744) Cabotegravir (GSK-1265744) CS-2197 SureCN82803 GSK744 (S/GSK1265744) Cabotegravir ,GSK744 Cabotegravir (GSK744, GSK1265744) USP/EP/BP (3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexa... Cabotegravir 13CD5 Cabot wei GSK1265744 Cabotegravir 13C,2H2,15N]-Cabotegravir Cabotegravir GSK744 GSK1265744 GSK-744 Cabotegravin Caboteve 1051375-10-0 C19H17F2N3O5 Inhibitors