5-Carboxy-8-hydroxyquinoline
- CAS No.
- 5852-78-8
- Chemical Name:
- 5-Carboxy-8-hydroxyquinoline
- Synonyms
- IOX1;8-Hydroxyquinoline-5-carboxylic Acid;CS-1524;IOX-1;IOX 1;IOX 1, >=98%;5-Carboxy-8-hydroxyquinoline;JMJD2 Inhibitor, 5-carboxy-8HQ;8-hydroxy-5-Quinolinecarboxylic acid;5-Carboxy-8-hydroxyquinoline USP/EP/BP;5-Quinolinecarboxylic acid, 8-hydroxy-
- CBNumber:
- CB02671446
- Molecular Formula:
- C10H7NO3
- Molecular Weight:
- 189.17
- MDL Number:
- MFCD18417145
- MOL File:
- 5852-78-8.mol
- MSDS File:
- SDS
| Melting point | 301 °C (decomp) |
|---|---|
| Boiling point | 464.5±30.0 °C(Predicted) |
| Density | 1.480±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 1.82±0.10(Predicted) |
| form | powder |
| color | white to brown |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChIKey | JGRPKOGHYBAVMW-UHFFFAOYSA-N |
| FDA UNII | JM015YQC1C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933499090 | |||||||||
| NFPA 704 |
|
5-Carboxy-8-hydroxyquinoline price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0067 | IOX1 ≥97% (HPLC) | 5852-78-8 | 5mg | $125 | 2024-03-01 | Buy |
| Sigma-Aldrich | 420201 | JMJD2 Inhibitor, 5-carboxy-8HQ | 5852-78-8 | 5mg | $209 | 2023-01-07 | Buy |
| Cayman Chemical | 11572 | IOX1 ≥97% | 5852-78-8 | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 11572 | IOX1 ≥97% | 5852-78-8 | 10mg | $143 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0067 | IOX1 ≥97% (HPLC) | 5852-78-8 | 25mg | $200 | 2024-03-01 | Buy |
5-Carboxy-8-hydroxyquinoline Chemical Properties,Uses,Production
Description
IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1?A broad spectrum 2-oxoglutarate oxygenase inhibitor, IOX 1 may be used to study hypoxic signaling.1?Cell permeable
Uses
8-Hydroxyquinoline-5-carboxylic Acid is an inhibitor of KDM2/7 histone demethylase. 8-Hydroxyquinoline-5-carboxylic acid has also shown potential to be used as a regulator of plant growth.
Uses
IOX1 has been used:
- To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy.
- In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling.
- to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.
Uses
5-Carboxy-8-hydroxyquinoline is an inhibitor of KDM2/7 histone demethylase. 5-Carboxy-8-hydroxyquinoline has also shown potential to be used as a regulator of plant growth.
Definition
ChEBI: 8-hydroxy-5-quinolinecarboxylic acid is a member of quinolines.
Biochem/physiol Actions
IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
storage
Store at +4°C
References
1) King et al. (2010), Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors; PLoS One, 5 e15535
5-Carboxy-8-hydroxyquinoline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
View Lastest Price from 5-Carboxy-8-hydroxyquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | 5-Carboxy-8-hydroxyquinoline
5852-78-8
|
US $1.00 / KG | 1KG | 85.0-99.8% | 20 tons | Career Henan Chemical Co |
-
- 5-Carboxy-8-hydroxyquinoline
5852-78-8
- US $1.00 / KG
- 85.0-99.8%
- Career Henan Chemical Co