(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL
- CAS No.
- 138090-06-9
- Chemical Name:
- (5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL
- Synonyms
- R)-THC;(R,R)-THC;(R,R)THC,(R,R) THC;(R,R)-CIS-DIETHYLTETRAHYDRO-2,8-CHRYSENEDIOL;5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol;cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol;(R,R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL;(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL;2,8-Chrysenediol, 5,11-diethyl-5,6,11,12-tetrahydro-, (5R,11R)-rel-
- CBNumber:
- CB0268769
- Molecular Formula:
- C22H24O2
- Molecular Weight:
- 320.42
- MDL Number:
- MFCD04039999
- MOL File:
- 138090-06-9.mol
| Melting point | >189°C (dec) |
|---|---|
| Boiling point | 519.0±50.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 20 mg/mL |
| form | solid |
| pka | 10.27±0.60(Predicted) |
| color | tan |
| Stability | Light Sensitive |
| FDA UNII | 89HTC2NWF3 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1990 | (R,R)-THC ≥98%(HPLC) | 138090-06-9 | 10 | $357 | 2021-12-16 | Buy |
| TRC | D445070 | cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol | 138090-06-9 | 50mg | $1320 | 2021-12-16 | Buy |
| ApexBio Technology | B6909 | (R,R)-THC | 138090-06-9 | 10mg | $528 | 2021-12-16 | Buy |
| CSNpharm | CSN22628 | (R,R)-THC | 138090-06-9 | 50mg | $644 | 2021-12-16 | Buy |
(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL Chemical Properties,Uses,Production
Uses
cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a fluorescent and selective ligand that can be used to investigate the interactions between ligand and receptor of estrogen receptors (ERs) (1,2,3). cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is an ERα agonist and an ERβ antagonist.
Uses
cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a fluorescent ligands for the estrogen receptor. A series of tetrahydrochrysenes were prepared as fluorescent ligands for the estrogen receptor.
Definition
ChEBI: (R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a carbotetracyclic compound that is 5,6,11,12-tetrahydrochrysene substituted by hydroxy groups at positions 2 and 8 and by ethyl groups at positions 5 and 11 (the 5R,11R-stereoisomer). It is an agonist of ER-alpha and antagonist of ER-beta receptors. It has a role as an estrogen receptor antagonist, an estrogen receptor agonist, a geroprotector and a neuroprotective agent. It is a carbotetracyclic compound and a polyphenol.
Biological Activity
Non-steroidal, selective estrogen receptor ligand; agonist at ER α receptor (K i = 9.0 nM) and antagonist at ER β receptor (K i = 3.6 nM).
storage
Store at -20°C
(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL Preparation Products And Raw materials
Raw materials
Preparation Products
(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55591 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |