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PF-06463922

PF-06463922
PF-06463922
CAS No.
1454846-35-5
Chemical Name:
PF-06463922
Synonyms
Loratinib;EOS-60936;PF-06463922;lee011/inc280;Lorlatinib,PF-06463922;PF-06463922, Lorlatinib;(R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile;(10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
CBNumber:
CB02716543
Molecular Formula:
C21H19FN6O2
Formula Weight:
406.4129632
MOL File:
1454846-35-5.mol

PF-06463922 Properties

SAFETY

PF-06463922 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18371 PF-06463922 ≥98% 1454846-35-5 1mg $29 2018-11-13 Buy
Cayman Chemical 18371 PF-06463922 ≥98% 1454846-35-5 5mg $73 2018-11-13 Buy
Cayman Chemical 18371 PF-06463922 ≥98% 1454846-35-5 10mg $131 2018-11-13 Buy

PF-06463922 Chemical Properties,Uses,Production

Uses

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.[Cayman Chemical]

PF-06463922 Preparation Products And Raw materials

Raw materials

Preparation Products


PF-06463922 Suppliers

Global( 103)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 wgp@nanjing-pharmaceutical.com CHINA 117 55
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 308 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 894 55
Shanghai Hope Chem Co., Ltd., 18501659228
sales@hope-chem.com sales@hope-chem.com China 82 55
Twochem Co.Ltd 021-58111628;18916269184
QQ 974669972 sales@twochem.com China 330 55
Wuhan NewBaiChuan Pharmaceutical Co., Ltd. 027-50476178;18607136887
QQ644526144 644526144@qq.com China 420 58
Nanjing Gold Pharmaceutical Technology Co. Ltd. 15905158493;15906146951
025-84209270 wgp@nanjing-pharmaceutical.com China 111 55
Wuhan Biocar Bio-Pharm Co., Ltd. 13343428090
86-027-87050469 sales@biocar.cn China 1726 50

1454846-35-5(PF-06463922)Related Search:


  • PF-06463922, Lorlatinib
  • (R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile
  • Lorlatinib,PF-06463922
  • EOS-60936
  • Loratinib
  • lee011/inc280
  • Inhibitors
  • API
  • PF-06463922
  • (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
  • 1454846-35-5
  • C21H19FN6O2
  • -
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