[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
- CAS No.
- 909725-62-8
- Chemical Name:
- [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
- Synonyms
- W146;W146 TFA;(R)-3-AMino-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt);(R)-3-AMINO-(3-HEXYLPHENYLAMINO)-4-OXOBUTYLPHOSPHONIC ACID (TFA SALT);W146;[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
- CBNumber:
- CB02717540
- Molecular Formula:
- C18H28F3N2O6P
- Molecular Weight:
- 456.3936906
- MDL Number:
- MFCD21602904
- MOL File:
- 909725-62-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| W146 (trifluoroacetate salt) ≥95% | 10009109 | 500μg | $86 |
| W146 (trifluoroacetate salt) ≥95% | 10009109 | 1mg | $161 |
| W146 (trifluoroacetate salt) ≥95% | 10009109 | 5mg | $676 |
| W146 (trifluoroacetate salt) ≥95% | 10009109 | 10mg | $1179 |
| W146 (trifluoroacetate salt) ≥95% | 10009109 | 500μg | $78 |
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10009109 | W146 (trifluoroacetate salt) ≥95% | 909725-62-8 | 500μg | $86 | 2026-04-30 | Buy |
| Cayman Chemical | 10009109 | W146 (trifluoroacetate salt) ≥95% | 909725-62-8 | 1mg | $161 | 2026-04-30 | Buy |
| Cayman Chemical | 10009109 | W146 (trifluoroacetate salt) ≥95% | 909725-62-8 | 5mg | $676 | 2026-04-30 | Buy |
| Cayman Chemical | 10009109 | W146 (trifluoroacetate salt) ≥95% | 909725-62-8 | 10mg | $1179 | 2026-04-30 | Buy |
| Cayman Chemical | 10009109 | W146 (trifluoroacetate salt) ≥95% | 909725-62-8 | 500μg | $78 | 2024-03-01 | Buy |
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Chemical Properties,Uses,Production
Uses
W146 is a selective antagonists of spingosine-1-phosphate receptor subtype 1.
Biological Activity
W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.
in vivo
W146 (5 mg/kg, ip, prior to AMD3100 administration) pre-treatment shows approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony forming assays, compared to that in mice treated with AMD3100 alone[3]
The W146-mediated augmentation of KSL-HSPC mobilization is specific, because pretreatment of mice with W140 is unable to produce any effect on AMD3100-stimulated KSL-HSPC mobilization. Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count in mice[3].
| Animal Model: | Mice (4-6-week-old)[3] . |
| Dosage: | 5 mg/kg. |
| Administration: | IP, 1 hour prior to AMD3100 (ADM) administration. |
| Result: | Significantly increased in KSL-HSPC mobilization compared to that in mice pretreated with dextran followed by AMD3100 administration. |
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Preparation Products And Raw materials
Raw materials
Preparation Products
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Codow Chemical Co.,Ltd. | -- | amy@howeipharm.com | China | 6687 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14603 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25022 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
909725-62-8([(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate))Related Search:
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