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FMoc-Val-Cit-PAB

FMoc-Val-Cit-PAB Structure
FMoc-Val-Cit-PAB structure
CAS No.
159858-22-7
Chemical Name:
FMoc-Val-Cit-PAB
Synonyms
Fmoc-Val-Cit-PAB-OH;(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate;FMoc-Val-Cit-PAB;TrastuzumabImpurity2;Fmoc-L-Val-Cit-PAB-OH;Fmoc-val-citrulline-para-aminobenzyl-OH;Trastuzumab Impurity 2 (Fmoc-Val-Cit-PAB-OH);4-(N-((9H-fluoren-9-yl)methoxycarbonyl)-L-valinyl-D-citrullinamido)benzyl alcohol;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
CBNumber:
CB02730901
Molecular Formula:
C33H39N5O6
Molecular Weight:
601.69
MDL Number:
MFCD22417106
MOL File:
159858-22-7.mol
MSDS File:
SDS
Last updated:2024-04-22 09:38:35
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FMoc-Val-Cit-PAB Properties

Melting point 204 °C(dec.)
Boiling point 914.2±65.0 °C(Predicted)
Density 1.276±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
form powder to crystal
pka 10.63±0.46(Predicted)
color White to Almost white
CAS DataBase Reference 159858-22-7

SAFETY

Risk and Safety Statements

HS Code  2924.29.7790

FMoc-Val-Cit-PAB price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical F1223 Fmoc-Val-Cit-PAB-OH 159858-22-7 25MG $16 2024-03-01 Buy
TCI Chemical F1223 Fmoc-Val-Cit-PAB-OH 159858-22-7 100MG $39 2024-03-01 Buy
AK Scientific 2998DP Fmoc-Val-Cit-PAB 159858-22-7 25mg $259 2021-12-16 Buy
ChemScene CS-5170 Fmoc-Val-Cit-PAB 97.15% 159858-22-7 250mg $300 2021-12-16 Buy
Iris Biotech GmbH ADC1030 Fmoc-Val-Cit-PAB 159858-22-7 250mg $303.75 2021-12-16 Buy
Product number Packaging Price Buy
F1223 25MG $16 Buy
F1223 100MG $39 Buy
2998DP 25mg $259 Buy
CS-5170 250mg $300 Buy
ADC1030 250mg $303.75 Buy

FMoc-Val-Cit-PAB Chemical Properties,Uses,Production

Uses

Fmoc-Val-Cit-PAB is a commonly used bridge for a degradable antibody-conjugated drug (ADC).

Description

Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition.

FMoc-Val-Cit-PAB synthesis

159858-21-6
623-04-1
159858-22-7
Synthesis of FMoc-Val-Cit-PAB from Fmoc-Val-Cit-OH and 4-Aminobenzyl alcohol

FMoc-Val-Cit-PAB Preparation Products And Raw materials

Raw materials

Carbamic acid, N-[(1S)-4-[(aminocarbonyl)amino]-1-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]butyl]-, 1,1-dimethylethyl ester N5-(aminocarbonyl)-N2-[(phenylmethoxy)carbonyl]-L-ornithine 4-Aminobenzyl alcohol H-Cit-PABA Fmoc-Cit-PABA
FMOC-L-Valine L-Citrulline Fmoc-Val-Cit-OH FMOC-VAL-OSU 9-Fluorenylmethyl chloroformate

1of2

Preparation Products

MC-Val-Cit-PAB FMoc-Val-Cit-PAB-PNP L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-

FMoc-Val-Cit-PAB Suppliers

Global( 211)Suppliers
Supplier Tel Email Country ProdList Advantage
Chemtour Biotech Co., Ltd
+8617327281506 market@chemtour.com China 1472 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9350 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 6992 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Jurong Coupling Biotechnology Co., Ltd. 		13656108824 coupling278191416@hotmail.com CHINA 184 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12478 58
Supplier Advantage
Chemtour Biotech Co., Ltd
58
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Biochempartner 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
BOC Sciences 		58
Jurong Coupling Biotechnology Co., Ltd. 		58
career henan chemical co 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58

Related articles

View Lastest Price from FMoc-Val-Cit-PAB manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fmoc-Val-Cit-PAB-OH pictures 2024-03-29 Fmoc-Val-Cit-PAB-OH
159858-22-7
 US $0.00 / g 10g >95.00% 10g Xian confluore Biological Technology Co., Ltd.
FMoc-Val-Cit-PAB pictures 2022-10-14 FMoc-Val-Cit-PAB
159858-22-7
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
FMoc-Val-Cit-PAB pictures 2020-01-10 FMoc-Val-Cit-PAB
159858-22-7
 US $6.00 / KG 1KG 98% 1kg, 5kg, 50kg Career Henan Chemical Co
  • Fmoc-Val-Cit-PAB-OH pictures
  • Fmoc-Val-Cit-PAB-OH
    159858-22-7
  • US $0.00 / g
  • >95.00%
  • Xian confluore Biological Technology Co., Ltd.
  • FMoc-Val-Cit-PAB pictures
  • FMoc-Val-Cit-PAB
    159858-22-7
  • US $0.00-0.00 / KG
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.

159858-22-7(FMoc-Val-Cit-PAB)Related Search:

FMoc-Val-Cit-PAB-PNP Val-cit-PAB-OH pyrene-2,7-diyldiboronic acid Fmoc-Val-Cit-OH MC-Val-Cit-PAB
FMoc-Val-Cit-PAB L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- (9H-fluoren-9-yl)methyl((S)-1-((())-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate (9H-fluoren-9-yl)methyl N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]carbamate Fmoc-val-citrulline-para-aminobenzyl-OH (9H-fluoren-9-yl)methyl ((2S)-1-((1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 4-(N-((9H-fluoren-9-yl)methoxycarbonyl)-L-valinyl-D-citrullinamido)benzyl alcohol Fmoc-Val-Cit-PAB-OH (9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate TrastuzumabImpurity2 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbam 9H-fluoren-9-ylmethyl N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate Trastuzumab Impurity 2 (Fmoc-Val-Cit-PAB-OH) Fmoc-L-Val-Cit-PAB-OH 159858-22-7 159858-22-8 1959858-22-7 ADCs ADC Linker ADC-Linker ADC-Linkers